Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Robin Fahraeus"'
Autor:
Konstantinos Karakostis, Monikaben Padariya, Aikaterini Thermou, Robin Fåhraeus, Umesh Kalathiya, Fritz Vollrath
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-5 (2024)
Abstract As species adapt to climatic changes, temperature-dependent functions of p53 in development, metabolism and cancer will adapt as well. Structural analyses of p53 epitopes interacting in response to environmental stressors, such as heat, may
Externí odkaz:
https://doaj.org/article/b608bb5feae546728508f828f44b25cc
Autor:
Konstantinos Karakostis, Laurence Malbert-Colas, Aikaterini Thermou, Borek Vojtesek, Robin Fåhraeus
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background The ATM kinase constitutes a master regulatory hub of DNA damage and activates the p53 response pathway by phosphorylating the MDM2 protein, which develops an affinity for the p53 mRNA secondary structure. Disruption of this inter
Externí odkaz:
https://doaj.org/article/6c35679e66534f3596b761aa7d227558
Autor:
Torben Wilms, Gulfaraz Khan, Philip J Coates, Nicola Sgaramella, Robin Fåhraeus, Asma Hassani, Pretty S Philip, Lena Norberg Spaak, Luigi Califano, Giuseppe Colella, Katarina Olofsson, Christos Loizou, Renato Franco, Karin Nylander
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184201 (2017)
Squamous cell carcinoma of the head and neck (SCCHN) comprises a large group of cancers in the oral cavity and nasopharyngeal area that typically arise in older males in association with alcohol/tobacco usage. Within the oral cavity, the mobile tongu
Externí odkaz:
https://doaj.org/article/6eb89198070f4046a934a58d19ba5366
Publikováno v:
PLoS Pathogens, Vol 6, Iss 10, p e1001151 (2010)
Viruses are known to employ different strategies to manipulate the major histocompatibility (MHC) class I antigen presentation pathway to avoid recognition of the infected host cell by the immune system. However, viral control of antigen presentation
Externí odkaz:
https://doaj.org/article/3c748d19f96a47849ed16c4e809558ed
Autor:
Lucia Haronikova, Ondrej Bonczek, Pavlina Zatloukalova, Filip Kokas-Zavadil, Martina Kucerikova, Philip J. Coates, Robin Fahraeus, Borivoj Vojtesek
Publikováno v:
Cellular & Molecular Biology Letters, Vol 26, Iss 1, Pp 1-33 (2021)
Abstract Since the discovery of the first MDM2 inhibitors, we have gained deeper insights into the cellular roles of MDM2 and p53. In this review, we focus on MDM2 inhibitors that bind to the p53-binding domain of MDM2 and aim to disrupt the binding
Externí odkaz:
https://doaj.org/article/d1e17d5c51ce4f04a150f6d6747e8079
Autor:
Monikaben Padariya, Sachin Kote, Marcos Mayordomo, Irena Dapic, Javier Alfaro, Ted Hupp, Robin Fahraeus, Umesh Kalathiya
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5072-5091 (2021)
The TAP1-TAP2 complex transports antigenic peptide substrates into the endoplasmic reticulum (ER). In ER, the peptides are further processed and loaded on the major histocompatibility class (MHC) I molecules by the peptide loading complex (PLC). The
Externí odkaz:
https://doaj.org/article/54f075f5da51411babab3c734b9d9081
Autor:
Xiaolian Gu, Linda Boldrup, Philip J Coates, Robin Fahraeus, Lixiao Wang, Torben Wilms, Lena Norberg‐Spaak, Nicola Sgaramella, Karin Nylander
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 5, Iss 4, Pp 240-247 (2019)
Abstract Immune cells and cytolytic activity within the tumor microenvironment are being intensively studied. Through transcriptome profiling, immune cell enumeration using the xCell tool and cytolytic activity quantification according to granzyme A
Externí odkaz:
https://doaj.org/article/665c6e99d71e40f0964646992cb9be99
Autor:
Monikaben Padariya, Umesh Kalathiya, Sara Mikac, Katarzyna Dziubek, Maria C. Tovar Fernandez, Ewa Sroka, Robin Fahraeus, Alicja Sznarkowska
Publikováno v:
Open Biology, Vol 11, Iss 3 (2021)
Virus–host interactions form an essential part of every aspect of life, and this review is aimed at looking at the balance between the host and persistent viruses with a focus on the immune system. The virus–host interaction is like a cat-and-mou
Externí odkaz:
https://doaj.org/article/630a48e96c40436f9bfe9c97168ff13f
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12744 (2021)
The nonsense-mediated mRNA decay (NMD) pathway rapidly detects and degrades mRNA containing premature termination codons (PTCs). UP-frameshift 1 (UPF1), the master regulator of the NMD process, has two alternatively-spliced isoforms; one carries 353-
Externí odkaz:
https://doaj.org/article/f279b6fd608d4ecb91839df72f8587fc
Autor:
Sara Mikac, Michał Rychłowski, Alicja Dziadosz, Alicja Szabelska-Beresewicz, Robin Fahraeus, Theodore Hupp, Alicja Sznarkowska
Publikováno v:
Antioxidants, Vol 10, Iss 5, p 786 (2021)
Nrf2 (nuclear factor erythroid 2 (NF-E2)-related factor 2) transcription factor is recognized for its pro-survival and cell protective role upon exposure to oxidative, chemical, or metabolic stresses. Nrf2 controls a number of cellular processes such
Externí odkaz:
https://doaj.org/article/b91170ba838c4337b30288c946e5aab4