Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Robin Ernst"'
Autor:
Susan H. Tam, Stephen G. McCarthy, Anthony A. Armstrong, Sandeep Somani, Sheng-Jiun Wu, Xuesong Liu, Alexis Gervais, Robin Ernst, Dorina Saro, Rose Decker, Jinquan Luo, Gary L. Gilliland, Mark L. Chiu, Bernard J. Scallon
Publikováno v:
Antibodies, Vol 6, Iss 3, p 12 (2017)
Engineering of fragment crystallizable (Fc) domains of therapeutic immunoglobulin (IgG) antibodies to eliminate their immune effector functions while retaining other Fc characteristics has numerous applications, including blocking antigens on Fc gamm
Externí odkaz:
https://doaj.org/article/e4effcd57176409f88ce8c9b266a42aa
Autor:
Cassandra Lowenstein, Subhasree Basu, Joshua Rusbuldt, Sathya Venkataramani, Robin Ernst, Steve Jarantow, Scott Brodeur, Daniel Rubio, Pharavee Jasiprasart, Margaret Yu, Brent Rupnow, Michael Russell
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::497b14e282368728449c391086461905
https://doi.org/10.1136/jitc-2022-sitc2022.1360
https://doi.org/10.1136/jitc-2022-sitc2022.1360
Autor:
Thomas J. Malia, Marc Vandermeeren, Hong Sun, Kristof Van Kolen, Marc Mercken, Rupesh Nanjunda, Gallen Triana-Baltzer, M. Borgers, Astrid Bottelbergs, Eilyn R. Lacy, Alexey Teplyakov, Tom Van De Casteele, John Q. Trojanowski, Clara Theunis, Hervé Maurin, Peter Larsen, Robin Ernst, Sheng-Jiun Wu, Cindy Wintmolders, Roland Willems, Randy Slemmon, Wendy Galpern, Jinquan Luo
Publikováno v:
Journal of Alzheimer's Disease. 77:1397-1416
Background: As a consequence of the discovery of an extracellular component responsible for the progression of tau pathology, tau immunotherapy is being extensively explored in both preclinical and clinical studies as a disease modifying strategy for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6c6c8a8bbb34392a44d1677aa443be
https://doi.org/10.3233/jad-200544
https://doi.org/10.3233/jad-200544
Autor:
Sathyadevi Venkataramani, Rajkumar Ganesan, Sanjaya Singh, Robin Ernst, Mehabaw G. Derebe, Steven Jacobs, Robert Wright, Jessica Kopenhaver
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Accelerated timelines necessitate the discovery of fully human antibodies as biotherapeutics using transgenic animals with a notion that such mAbs bypass humanization. A transgenic animal derived mAb (PCa75) targeted against a prostate cancer antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1711320f2448796fe9892a57ed222fad
https://doi.org/10.1038/s41598-020-66636-z
https://doi.org/10.1038/s41598-020-66636-z
Autor:
Xuesong Liu, Marc Vandermeeren, Raymond Sweet, Robin Ernst, Jinquan Luo, Thomas J. Malia, Marc Mercken, Alexey Teplyakov, Eilyn R. Lacy, Gary L. Gilliland, Sheng-Jiun Wu
Publikováno v:
Proteins
Microtubule‐associated protein tau becomes abnormally phosphorylated in Alzheimer's disease and other tauopathies and forms aggregates of paired helical filaments (PHF‐tau). AT8 is a PHF‐tau‐specific monoclonal antibody that is a commonly use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdd5994e34021df00f67efd7cd04933
https://doi.org/10.1002/prot.24988
https://doi.org/10.1002/prot.24988
Autor:
Dorina Saro, Susan H. Tam, Sandeep Somani, Mark L. Chiu, Bernard Scallon, Alexis Gervais, Gary L. Gilliland, Xuesong Liu, Sheng-Jiun Wu, Rose Decker, Stephen G. McCarthy, Jinquan Luo, Robin Ernst, Anthony A. Armstrong
Publikováno v:
Antibodies, Vol 6, Iss 3, p 12 (2017)
Antibodies; Volume 6; Issue 3; Pages: 12
Antibodies
Antibodies; Volume 6; Issue 3; Pages: 12
Antibodies
Engineering of fragment crystallizable (Fc) domains of therapeutic immunoglobulin (IgG) antibodies to eliminate their immune effector functions while retaining other Fc characteristics has numerous applications, including blocking antigens on Fc gamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc3a11d7bef6ec9f4eb105eae0113a1
https://pubmed.ncbi.nlm.nih.gov/31548527
https://pubmed.ncbi.nlm.nih.gov/31548527
Autor:
Di Zhang, John Kehoe, Iqbal S. Grewal, Eilyn R. Lacy, Jackson Wong, Alexey Teplyakov, Weimin Li, Judith Hailey, Edward W. Thompson, Linda Okonkwo, Rupesh Nanjunda, Robin Ernst, John Alvarez, Sam Wu, Mark Salvati, Cam Holland, Patrick Wilkinson, Moitreyee Chatterjee-Kishore, Anhco Nguyen, Michelle Kinder, Marco Gottardis, Gerald Chu
Publikováno v:
Cancer Research. 78:3813-3813
Background: Checkpoint blockade of PD-1/PDL-1 or CTLA-4 has demonstrated clinical benefit in a subset of cancer patients (pts). To further improve the outcome, approaches to deplete immunosuppressive Tregs are being developed. Emerging evidence suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1546af2abec7abc5ca6b2e9ca189b664
https://doi.org/10.1158/1538-7445.am2018-3813
https://doi.org/10.1158/1538-7445.am2018-3813
Autor:
Donna L. Montgomery, Barrett R. Harvey, Richard Hampton, Renee Hrin, Michael D. Miller, William R. Strohl, Zhiqiang An, Bin Su, Robin Ernst, Ying-Jie Wang
Publikováno v:
Journal of Immunological Methods. 322:94-103
Screening antibodies from phage displayed in vitro libraries and from affinity maturation of lead antibodies requires testing of antibody fragments (scFvs and Fabs) for function and binding affinities. Crude scFv or Fab periplasmic preparations from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09d0c3fd9867576287035738198b2ab
https://doi.org/10.1016/j.jim.2007.02.006
https://doi.org/10.1016/j.jim.2007.02.006
Autor:
Hans Weber, Norbert Peekhaus, Sharon Adamski, Lingyi Huang, Hai Zhuan Zhang, Chi-Sung Chiu, Salvatore Vitelli, Stephen E. Alves, Hilary A. Wilkinson, Nan Wei, Robin Ernst, Weirong Wang, Beth A. Arnold, Gregory M. Dillon, Edward M. Murray, Richard Hampton, Fubao Wang, Jing Zhang Zhao, Lora Hamuro, Jiangyong Miao, Helmut Glantschnig, Janet Lineberger
Publikováno v:
The journals of gerontology. Series A, Biological sciences and medical sciences. 68(10)
Myostatin is a highly conserved member of the transforming growth factor-β ligand family known to regulate muscle growth via activation of activin receptors. A fusion protein consisting of the extracellular ligand-binding domain of activin type IIB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495b7f7ea78d6572dfba5b051099716b
https://pubmed.ncbi.nlm.nih.gov/23525481
https://pubmed.ncbi.nlm.nih.gov/23525481
Autor:
Cheryl Ireland, Dennis M. Zaller, Arna Andrews, Manuel Baca, Nicholas T. Redpath, Thomas P. J. Garrett, Yibin Xu, Robin Ernst, Douglas J. Hilton, Andrea Woods, William R. Strohl, Cindy S. Luo, Louis Fabri, Ping Lu, Nicos A. Nicola, Peter E. Czabotar, Gail Forrest, Jian-Guo Zhang, Andrew D. Nash, Hal Braley, Nicholas J. Wilson, Zhiqiang An
Publikováno v:
The Biochemical journal. 451(2)
Gene deletion studies in mice have revealed critical roles for IL (interleukin)-4 and -13 in asthma development, with the latter controlling lung airways resistance and mucus secretion. We have now developed human neutralizing monoclonal antibodies a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45eb3760f8aad5f03cd91c2019461d1c
https://pubmed.ncbi.nlm.nih.gov/23535171
https://pubmed.ncbi.nlm.nih.gov/23535171