Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Robin E. C. Lee"'
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 7, Pp n/a-n/a (2024)
Abstract Recently, there is a rise in studies that recognize the importance of targeting ubiquitin and related molecular machinery in various therapeutic contexts. Here we briefly discuss the history of ubiquitin, its biological roles in protein degr
Externí odkaz:
https://doaj.org/article/f79c51b17dd14715a4d436fbabfe127b
Autor:
Nicolas A. Pabon, Qiuhong Zhang, J. Agustin Cruz, David L. Schipper, Carlos J. Camacho, Robin E. C. Lee
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Chemical perturbation of specific protein–protein interactions is notoriously difficult, yet necessary when complete inhibition of a signalling pathway is detrimental to the cell. Here, the authors use a systems approach and identify two first-in-c
Externí odkaz:
https://doaj.org/article/7827aa4fe11a43db972da048c22b3cbb
Autor:
Manjulata Singh, Katsuhiko Warita, Tomoko Warita, James R. Faeder, Robin E. C. Lee, Shilpa Sant, Zoltán N. Oltvai
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Cell-to-cell differences in protein expression in normal tissues and tumors are a common phenomenon, but the underlying principles that govern this heterogeneity are largely unknown. Here, we show that in monolayer cancer cell-line cultures,
Externí odkaz:
https://doaj.org/article/b8b1173131934a50bf33d3f5f39499ac
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 3, p e1007669 (2020)
Systems Biology models reveal relationships between signaling inputs and observable molecular or cellular behaviors. The complexity of these models, however, often obscures key elements that regulate emergent properties. We use a Bayesian model reduc
Externí odkaz:
https://doaj.org/article/5466ee05120845d0a59206ae11493e48
Autor:
Steven W. Smeal, Sanjana Gupta, Qiuhong Zhang, J. Agustin Cruz, Robin E. C. Lee, David L. Schipper, Chaitanya S. Mokashi, Yue Guo, Gabriel J. Kowalczyk
Publikováno v:
Science Advances
A variable-gain stochastic pooling motif mediates robust and parsimonious information transmission from the extracellular milieu.
A myriad of inflammatory cytokines regulate signaling pathways to maintain cellular homeostasis. The IκB kinase (I
A myriad of inflammatory cytokines regulate signaling pathways to maintain cellular homeostasis. The IκB kinase (I
Publikováno v:
iScience, Vol 19, Iss, Pp 586-596 (2019)
iScience
iScience
Summary Cellular microenvironments are dynamic. When exposed to extracellular cues, such as changing concentrations of inflammatory cytokines, cells activate signaling networks that mediate fate decisions. Exploring responses broadly to time-varying
Autor:
David L. Schipper, Chaitanya S. Mokashi, Sanjana Gupta, Qiuhong Zhang, Yue Guo, Robin E. C. Lee, Gabriel J. Kowalczyk, J. Agustin Cruz
A myriad of inflammatory cytokines regulate signaling pathways to maintain cellular homeostasis. The IKK complex is an integration hub for cytokines that govern NF-κB signaling. In response to inflammation, IKK is activated through recruitment to re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53c2e4db1fab1e39c8356981452440af
https://doi.org/10.1101/2021.03.29.437543
https://doi.org/10.1101/2021.03.29.437543
Autor:
Robin E. C. Lee, Yue Guo
Single-cell imaging of individual mRNAs has revealed core mechanisms of the central dogma. However, most approaches require cell fixation or have limited sensitivity for live-cell applications. Here, we describe SunRISE (SunTag-based Reporter for Ima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b19587391699386ce2e3936df013b58b
https://doi.org/10.1101/2020.10.05.326660
https://doi.org/10.1101/2020.10.05.326660
Autor:
Qiuhong Zhang, Robin E. C. Lee, Gabriel J. Kowalczyk, Yue Guo, Natalie Sauerwald, J. Agustin Cruz
Publikováno v:
Bioinformatics
Motivation Many biological processes are regulated by single molecules and molecular assemblies within cells that are visible by microscopy as punctate features, often diffraction limited. Here, we present detecting-NEMO (dNEMO), a computational tool
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ac44d122c4e349e2b9ec56c0a60c5b
Autor:
Yanrong Zhang, Robin E. C. Lee, Xiaoxu Zheng, Allen Ko, Chaitanya S. Mokashi, Zachary Freyberg, Fei Han, Pedro A. Jose, Ines Armando, John J Gildea, Gaosi Xu, Robin A. Felder, Prasad Konkalmatt, Zachary J. Farino, Laureano D. Asico, Megha Kumar
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-21 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-21 (2019)
The Wnt/β-catenin pathway is one of the most conserved signaling pathways across species with essential roles in development, cell proliferation, and disease. Wnt signaling occurs at the protein level and via β-catenin-mediated transcription of tar