Drug delivery, biodistribution and anti-EGFR activity: theragnostic nanoparticles for simultaneousin vivodelivery of tyrosine kinase inhibitors and kinase activity biosensors

Autor: Helen Allan, Matthias Glaser, Erik Årstad, Robin Bofinger, Gregory Weitsman, Daniel Hochhauser, Tammy L. Kalber, Kerstin Sander, Tony Ng, Rachel Evans, Helen C. Hailes, Alethea B. Tabor

Publikováno v: Nanoscale. 13:18520-18535

In vivo delivery of small molecule therapeutics to cancer cells, assessment of the selectivity of administration, and measuring the efficacity of the drug in question at the molecule level, are important ongoing challenges in developing new classes o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21cf0bfc56ddd371f77f143db3789a24
https://doi.org/10.1039/d1nr02770k

Effect of Liposomal Encapsulation on the Chemical Exchange Properties of Diamagnetic CEST Agents

Autor: Alethea B. Tabor, Eleni Demetriou, Helen C. Hailes, Xavier Golay, Harriet Story, Robin Bofinger

Publikováno v: The Journal of Physical Chemistry. B

Exogenous chemical exchange saturation transfer (CEST) contrast agents such as glucose or 2-deoxy-d-glucose (2-DG) have shown high sensitivities and significant potential for monitoring glucose uptake in tumors with MRI. Here, we show that liposome e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dae92779589df7000ece9833ea91f84
https://doi.org/10.1021/acs.jpcb.9b02280

2D and 3D surface photopatterning via laser-promoted homopolymerization of a perfluorophenyl azide-substituted BODIPY

Autor: Guillaume Raffy, Jean-Marc Vincent, Nathan D. McClenaghan, Robin Bofinger, Arnaud Tron, André Del Guerzo

Publikováno v: Nanoscale
Nanoscale, Royal Society of Chemistry, 2017, 9 (43), pp.16908-16914. ⟨10.1039/c7nr06848d⟩

An innovative photopatterning process is described that allows, in a single laser-promoted operation, the covalent attachment of a molecule on a surface (2D patterning – xy dimensions) and its photopolymerization to grow micro-/nanostructures with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8318ed3c410fdc054d963d30e63e9753
https://doi.org/10.1039/c7nr06848d

Photoreversible stretching of a BAPTA chelator marshalling Ca 2+ -binding in aqueous media

Autor: Robin Bofinger, Aurélien Ducrot, Arnaud Tron, Nathan D. McClenaghan, Jean-Luc Pozzo, Ingrid Sanz Beguer

Publikováno v: Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Beilstein-Institut, 2019, 15, pp.2801-2811. ⟨10.3762/bjoc.15.273⟩
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2801-2811 (2019)

Free calcium ion concentration is known to govern numerous biological processes and indeed calcium acts as an important biological secondary messenger for muscle contraction, neurotransmitter release, ion-channel gating, and exocytosis. As such, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28225ae580d55e61049d20821999b36b
https://hal.archives-ouvertes.fr/hal-03155306

Tunable Semiconducting Polymer Nanoparticles with INDT-Based Conjugated Polymers for Photoacoustic Molecular Imaging

Autor: Thomas, Stahl, Robin, Bofinger, Ivan, Lam, Kealan J, Fallon, Peter, Johnson, Olumide, Ogunlade, Vessela, Vassileva, R Barbara, Pedley, Paul C, Beard, Helen C, Hailes, Hugo, Bronstein, Alethea B, Tabor

Publikováno v: Bioconjugate Chemistry

Photoacoustic imaging combines both excellent spatial resolution with high contrast and specificity, without the need for patients to be exposed to ionizing radiation. This makes it ideal for the study of physiological changes occurring during tumori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25f3f1f22a8d31224d89dde41c9201dd
https://pubmed.ncbi.nlm.nih.gov/28561568