Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Robin Beekhof"'
Autor:
Robin Beekhof, Carolien vanAlphen, Alex A Henneman, Jaco C Knol, Thang V Pham, Frank Rolfs, Mariette Labots, Evan Henneberry, Tessa YS Le Large, Richard R deHaas, Sander R Piersma, Valentina Vurchio, Andrea Bertotti, Livio Trusolino, Henk MW Verheul, Connie R Jimenez
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 5, Pp n/a-n/a (2019)
Externí odkaz:
https://doaj.org/article/6ba361944f9542e4bc20ad0b8506ee32
Autor:
Jaco C. Knol, Inge de Reus, Tim Schelfhorst, Robin Beekhof, Meike de Wit, Sander R. Piersma, Thang V. Pham, Egbert F. Smit, Henk M.W. Verheul, Connie R. Jiménez
Publikováno v:
EuPA Open Proteomics, Vol 11, Iss C, Pp 11-15 (2016)
Extracellular vesicles (EVs) are cell-secreted membrane vesicles enclosed by a lipid bilayer derived from endosomes or from the plasma membrane. Since EVs are released into body fluids, and their cargo includes tissue-specific and disease-related mol
Externí odkaz:
https://doaj.org/article/bb4a8f3db5ab4f28ad192f7a0c7580f1
Autor:
Dennis Poel, Lenka N.C. Boyd, Robin Beekhof, Tim Schelfhorst, Thang V. Pham, Sander R. Piersma, Jaco C. Knol, Connie R. Jimenez, Henk M.W. Verheul, Tineke E. Buffart
Publikováno v:
Cells, Vol 8, Iss 9, p 1111 (2019)
Most patients with advanced colorectal cancer (CRC) eventually develop resistance to systemic combination therapy. miR-195-5p and miR-497-5p are downregulated in CRC tissues and associated with drug resistance. Sensitization to 5-FU, oxaliplatin, and
Externí odkaz:
https://doaj.org/article/b04312636a034cdc827e41293782ba9c
Autor:
Richard J. Honeywell, Connie R. Jimenez, Godefridus J. Peters, Sander R. Piersma, Martijn R. Meijerink, Robin Beekhof, Richard de Goeij de Haas, Maarten Neerincx, Jaco C. Knol, Donald L. van der Peet, Nicole C.T. van Grieken, Thang V. Pham, Johannes C. van der Mijn, Henk M.W. Verheul, Henk L. Dekker, Mariette Labots
Publikováno v:
Cancers, 12(2):330. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 12
Cancers
Volume 12
Issue 2
Cancers, 12, 2
Labots, M, Pham, T V, Honeywell, R J, Knol, J C, Beekhof, R, de Goeij-de Haas, R, Dekker, H, Neerincx, M, Piersma, S R, van der Mijn, J C, van der Peet, D L, Meijerink, M R, Peters, G J, van Grieken, N C T, Jiménez, C R & Verheul, H M W 2020, ' Kinase Inhibitor Treatment of Patients with Advanced Cancer Results in High Tumor Drug Concentrations and in Specific Alterations of the Tumor Phosphoproteome ', Cancers, vol. 12, no. 2, 330 . https://doi.org/10.3390/cancers12020330
Cancers, Vol 12, Iss 2, p 330 (2020)
Cancers, 12
Cancers
Volume 12
Issue 2
Cancers, 12, 2
Labots, M, Pham, T V, Honeywell, R J, Knol, J C, Beekhof, R, de Goeij-de Haas, R, Dekker, H, Neerincx, M, Piersma, S R, van der Mijn, J C, van der Peet, D L, Meijerink, M R, Peters, G J, van Grieken, N C T, Jiménez, C R & Verheul, H M W 2020, ' Kinase Inhibitor Treatment of Patients with Advanced Cancer Results in High Tumor Drug Concentrations and in Specific Alterations of the Tumor Phosphoproteome ', Cancers, vol. 12, no. 2, 330 . https://doi.org/10.3390/cancers12020330
Cancers, Vol 12, Iss 2, p 330 (2020)
Identification of predictive biomarkers for targeted therapies requires information on drug exposure at the target site as well as its effect on the signaling context of a tumor. To obtain more insight in the clinical mechanism of action of protein k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9ab5f80e090bb9908796d5a68427f5
https://research.vumc.nl/en/publications/0819c55f-746c-40ee-882b-d23b37439956
https://research.vumc.nl/en/publications/0819c55f-746c-40ee-882b-d23b37439956
Autor:
Sander R. Piersma, Carolien van Alphen, Robin Beekhof, Johan van Meerloo, Jeroen Janssen, Jaco C. Knol, Jacqueline Cloos, Thang V. Pham, David G. J. Cucchi, Connie R. Jimenez, Gert J. Ossenkoppele, Henk M.W. Verheul, Alex A. Henneman
Publikováno v:
Molecular & Cellular Proteomics, 19, 884-899
Molecular and Cellular Proteomics, 19(5), 884-899. American Society for Biochemistry and Molecular Biology Inc.
van Alphen, C, Cloos, J, Beekhof, R, Cucchi, DGJ, Piersma, SR, Knol, J C, Henneman, AA, Pham, TV, van Meerloo, J, Ossenkoppele, GJ, Verheul, HMW, Janssen, JJWM & Jimenez, CR 2020, ' Phosphotyrosine-based phosphoproteomics for target identification and drug response prediction in AML cell lines ', Molecular and Cellular Proteomics, vol. 19, no. 5, pp. 884-899 . https://doi.org/10.1074/mcp.RA119.001504
Mol Cell Proteomics
Molecular & Cellular Proteomics, 19, 5, pp. 884-899
Molecular and Cellular Proteomics, 19(5), 884-899. American Society for Biochemistry and Molecular Biology Inc.
van Alphen, C, Cloos, J, Beekhof, R, Cucchi, DGJ, Piersma, SR, Knol, J C, Henneman, AA, Pham, TV, van Meerloo, J, Ossenkoppele, GJ, Verheul, HMW, Janssen, JJWM & Jimenez, CR 2020, ' Phosphotyrosine-based phosphoproteomics for target identification and drug response prediction in AML cell lines ', Molecular and Cellular Proteomics, vol. 19, no. 5, pp. 884-899 . https://doi.org/10.1074/mcp.RA119.001504
Mol Cell Proteomics
Molecular & Cellular Proteomics, 19, 5, pp. 884-899
Contains fulltext : 220824.pdf (Publisher’s version ) (Open Access) Acute myeloid leukemia (AML) is a clonal disorder arising from hematopoietic myeloid progenitors. Aberrantly activated tyrosine kinases (TK) are involved in leukemogenesis and are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b902debc546ae97c27687384b063556
http://hdl.handle.net/2066/220824
http://hdl.handle.net/2066/220824
Autor:
Henk M.W. Verheul, Richard de Goeij de Haas, Mariette Labots, Jaco C. Knol, Thang V. Pham, Sander R. Piersma, Alex A. Henneman, Robin Beekhof, Hanneke van der Wijngaart, Connie R. Jimenez
Publikováno v:
Journal of Clinical Oncology. 39:e16556-e16556
e16556 Background: Sunitinib, a multi-targeted antiangiogenic tyrosine kinase inhibitor has improved the outcome of patients with advanced RCC considerably. Unfortunately, ± 30% of patients are intrinsically resistant, which underscores the urgent n
Autor:
Richard R. de Haas, Thang V. Pham, Connie R. Jimenez, Mariette Labots, Jaco C. Knol, Nicole C.T. van Grieken, Johannes C. van der Mijn, Sander R. Piersma, Henk L. Dekker, Henk M.W. Verheul, Robin Beekhof
Publikováno v:
Journal of Proteomics, 162, 99-107. Elsevier
Labots, M, van der Mijn, J C, Beekhof, R, Piersma, S R, de Goeij-de Haas, R R, Pham, T V, Knol, J C, Dekker, H, van Grieken, N C T, Verheul, H M W & Jiménez, C R 2017, ' Phosphotyrosine-based-phosphoproteomics scaled-down to biopsy level for analysis of individual tumor biology and treatment selection ', Journal of Proteomics, vol. 162, pp. 99-107 . https://doi.org/10.1016/j.jprot.2017.04.014
Labots, M, van der Mijn, J C, Beekhof, R, Piersma, S R, de Goeij-de Haas, R R, Pham, T V, Knol, J C, Dekker, H, van Grieken, N C T, Verheul, H M W & Jiménez, C R 2017, ' Phosphotyrosine-based-phosphoproteomics scaled-down to biopsy level for analysis of individual tumor biology and treatment selection ', Journal of Proteomics, vol. 162, pp. 99-107 . https://doi.org/10.1016/j.jprot.2017.04.014
Mass spectrometry-based phosphoproteomics of cancer cell and tissue lysates provides insight in aberrantly activated signaling pathways and potential drug targets. For improved understanding of individual patient's tumor biology and to allow selectio
Autor:
Connie R. Jimenez, Thang V. Pham, Henk M.W. Verheul, Tim Schelfhorst, Sander R. Piersma, Lenka N.C. Boyd, Robin Beekhof, Jaco C. Knol, Dennis Poel, Tineke E. Buffart
Publikováno v:
Cells
Poel, D, Boyd, L N C, Beekhof, R, Schelfhorst, T, Pham, T V, Piersma, S R, Knol, J C, Jimenez, C R, Verheul, H M W & Buffart, T E 2019, ' Proteomic Analysis of miR-195 and miR-497 Replacement Reveals Potential Candidates that Increase Sensitivity to Oxaliplatin in MSI/P53wt Colorectal Cancer Cells ', Cells, vol. 8, no. 9 . https://doi.org/10.3390/cells8091111
Cells, 8(9). MDPI Multidisciplinary Digital Publishing Institute
Cells, 8, 9
Volume 8
Issue 9
Cells, Vol 8, Iss 9, p 1111 (2019)
Cells, 8
Poel, D, Boyd, L N C, Beekhof, R, Schelfhorst, T, Pham, T V, Piersma, S R, Knol, J C, Jimenez, C R, Verheul, H M W & Buffart, T E 2019, ' Proteomic Analysis of miR-195 and miR-497 Replacement Reveals Potential Candidates that Increase Sensitivity to Oxaliplatin in MSI/P53wt Colorectal Cancer Cells ', Cells, vol. 8, no. 9 . https://doi.org/10.3390/cells8091111
Cells, 8(9). MDPI Multidisciplinary Digital Publishing Institute
Cells, 8, 9
Volume 8
Issue 9
Cells, Vol 8, Iss 9, p 1111 (2019)
Cells, 8
Most patients with advanced colorectal cancer (CRC) eventually develop resistance to systemic combination therapy. miR-195-5p and miR-497-5p are downregulated in CRC tissues and associated with drug resistance. Sensitization to 5-FU, oxaliplatin, and
Autor:
Livio Trusolino, Richard R. de Haas, Connie R. Jimenez, Jaco C. Knol, Frank Rolfs, Andrea Bertotti, Tessa Y S Le Large, Evan Henneberry, Mariette Labots, Thang V. Pham, Alex A. Henneman, Carolien van Alphen, Henk M.W. Verheul, Valentina Vurchio, Sander R. Piersma, Robin Beekhof
Publikováno v:
Molecular Systems Biology, 15(4):e8250. Wiley-Blackwell
Molecular Systems Biology
Molecular Systems Biology, Vol 15, Iss 4, Pp n/a-n/a (2019)
Molecular systems biology, 15(4):e8250. Wiley-Blackwell
Molecular Systems Biology, 15, 5, pp. e8981
Molecular Systems Biology, 15, e8981
Beekhof, R, van Alphen, C, Henneman, A A, Knol, J C, Pham, T V, Rolfs, F, Labots, M, Henneberry, E, le Large, T Y, de Haas, R R, Piersma, S R, Vurchio, V, Bertotti, A, Trusolino, L, Verheul, H M & Jimenez, C R 2019, ' INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases ', Molecular Systems Biology, vol. 15, no. 4, e8250, pp. e8250 . https://doi.org/10.15252/msb.20188250
Molecular Systems Biology, Vol 15, Iss 5, Pp n/a-n/a (2019)
Molecular Systems Biology
Molecular Systems Biology, Vol 15, Iss 4, Pp n/a-n/a (2019)
Molecular systems biology, 15(4):e8250. Wiley-Blackwell
Molecular Systems Biology, 15, 5, pp. e8981
Molecular Systems Biology, 15, e8981
Beekhof, R, van Alphen, C, Henneman, A A, Knol, J C, Pham, T V, Rolfs, F, Labots, M, Henneberry, E, le Large, T Y, de Haas, R R, Piersma, S R, Vurchio, V, Bertotti, A, Trusolino, L, Verheul, H M & Jimenez, C R 2019, ' INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases ', Molecular Systems Biology, vol. 15, no. 4, e8250, pp. e8250 . https://doi.org/10.15252/msb.20188250
Molecular Systems Biology, Vol 15, Iss 5, Pp n/a-n/a (2019)
Identifying hyperactive kinases in cancer is crucial for individualized treatment with specific inhibitors. Kinase activity can be discerned from global protein phosphorylation profiles obtained with mass spectrometry‐based phosphoproteomics. A maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7461b8cc06b839a6a06ab5c5ac275894
https://research.vumc.nl/en/publications/2358a980-b83e-4564-9b8d-8a9dca3f9426
https://research.vumc.nl/en/publications/2358a980-b83e-4564-9b8d-8a9dca3f9426
Autor:
Richard R. de Haas, Sander R. Piersma, Thang V. Pham, Jaco C. Knol, Connie R. Jimenez, Robin Beekhof, Carolien van Alphen, Henk M.W. Verheul, Alex A. Henneman, Mariette Labots, Tessa Y S Le Large, Evan Henneberry, Frank Rolfs
Identifying (hyper)active kinases in cancer patient tumors is crucial to enable individualized treatment with specific inhibitors. Conceptually, kinase activity can be gleaned from global protein phosphorylation profiles obtained with mass spectromet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae9c5e2abc6ddd90f1d16c64f8356c1