Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Robin B Lee"'
Autor:
Rakesh, David F Bruhn, Michael S Scherman, Lisa K Woolhiser, Dora B Madhura, Marcus M Maddox, Aman P Singh, Robin B Lee, Julian G Hurdle, Michael R McNeil, Anne J Lenaerts, Bernd Meibohm, Richard E Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87909 (2014)
The reductively activated nitroaromatic class of antimicrobials, which include nitroimidazole and the more metabolically labile nitrofuran antitubercular agents, have demonstrated some potential for development as therapeutics against dormant TB baci
Externí odkaz:
https://doaj.org/article/5a17b56fb20942aa854494bae86ab371
Autor:
Mingming Zhang, Allan M. Prior, Marcus M. Maddox, Wan-Jou Shen, Kirk E. Hevener, David F. Bruhn, Robin B. Lee, Aman P. Singh, Justin Reinicke, Charles J. Simmons, Julian G. Hurdle, Richard E. Lee, Dianqing Sun
Publikováno v:
ACS Omega, Vol 3, Iss 12, Pp 18343-18360 (2018)
Externí odkaz:
https://doaj.org/article/27abe659138b4f32a2e630d0506d1f8f
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 2, Pp 455-463 (2008)
Mycobacteria, including Mycobacterium tuberculosis, are characterized by a unique cell wall rich in complex lipids, glycolipids, polyketides, and terpenoids. Many of these metabolites have been shown to play important roles in mycobacterial virulence
Externí odkaz:
https://doaj.org/article/e0fbc408625a4d449b6eb5b3f2819827
Autor:
Richard E. Lee, Suresh Dharuman, Jiuyu Liu, Stephanie M. Reeve, Carl W Thompson, Robin B. Lee, John M Elmore, Erik C. Böttger, Laura A. Wilt, Dimitri Shcherbakov
Publikováno v:
Journal of Antibiotics, 74 (6)
The Journal of Antibiotics
The Journal of Antibiotics
Spectinomycin, an aminocyclitol antibiotic, is subject to inactivation by aminoglycoside modifying enzymes (AMEs) through adenylylation or phosphorylation of the 6-hydroxy group position. In this study, the effects of deoxygenation of the 2- and 6-hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab27dbc8b070686fe8d6a6b4c68320e
https://hdl.handle.net/20.500.11850/488447
https://hdl.handle.net/20.500.11850/488447
Autor:
Darcie J. Miller, Miranda J. Wallace, Ying Zhao, LaFleur, William R. Shadrick, Kim Lewis, John M Elmore, Y. Li, Jiuyu Liu, Elizabeth C. Griffith, Rajendra Tangallapally, Martin N. Cheramie, Zhong Zheng, Richard E. Lee, Brian P. Conlon, Lei Yang, Aman P. Singh, Robin B. Lee
Publikováno v:
ACS Infect Dis
Acyldepsipeptides are a unique class of antibiotics that act via allosterically dysregulated activation of the bacterial caseinolytic protease (ClpP). The ability of ClpP activators to kill nongrowing bacteria represents a new opportunity to combat d
Autor:
Marcus M. Maddox, Charles J. Simmons, Mingming Zhang, Allan M. Prior, Kirk E. Hevener, David F. Bruhn, Dianqing Sun, Justin Reinicke, Julian G Hurdle, Aman P. Singh, Robin B. Lee, Wan-Jou Shen, Richard E. Lee
Publikováno v:
ACS Omega, Vol 3, Iss 12, Pp 18343-18360 (2018)
ACS Omega
ACS Omega
A series of novel chalcone and thiol-Michael addition analogues was synthesized and tested against Mycobacterium tuberculosis and other clinically significant bacterial pathogens. Previously reported chalcone-like antibacterials (1a–c and 2) were u
Autor:
Elizabeth C. Griffith, Miranda J. Wallace, Stephanie M. Reeve, Clifford T. Gee, Gregory A. Phelps, Robin B. Lee, John M Elmore, Jiangwei Yao, William C. Wright, Richard E. Lee, Taosheng Chen, Dinesh M. Fernando, Suresh Dharuman
Publikováno v:
ACS Infect Dis
Increasing rates of drug-resistant Gram-negative (GN) infections, combined with a lack of new GN-effective antibiotic classes, are driving the need for the discovery of new agents. Bacterial metabolism represents an underutilized mechanism of action
Autor:
Julian G Hurdle, Ghee Teng Tan, Robin B. Lee, Lissa S. Tsutsumi, Miranda J. Wallace, John M Elmore, Ravikanthreddy Marreddy, Richard E. Lee, Dianqing Sun, Uyen T. Dang
Publikováno v:
ACS combinatorial science. 20(3)
Herein we report the antibacterial structure-activity relationships of cyclic hexapeptide wollamide analogs derived from solid-phase library synthesis. Wollamide B, a cyclic hexapeptide natural product, has been previously found to have activity agai
Autor:
Yuk-Ching Tse-Dinh, Charles J. Simmons, Li Feng, Shayna Sandhaus, Gagandeep Narula, Dianqing Sun, Lissa S. Tsutsumi, Xiaoqian Wu, Julian G. Hurdle, Marcus M. Maddox, David F. Bruhn, Richard E. Lee, Zahidul Alam, Robin B. Lee
Publikováno v:
Journal of Medicinal Chemistry
On the basis of recently reported abyssinone II and olympicin A, a series of chemically modified flavonoid phytochemicals were synthesized and evaluated against Mycobacterium tuberculosis and a panel of Gram-positive and -negative bacterial pathogens
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux
Autor:
Julian G. Hurdle, Rashid Akbergenov, Cristina Villellas, José A. Aínsa, Michael R. McNeil, Robin B. Lee, Jiuyu Liu, Dora B. Madhura, Erik C. Böttger, Rakesh, Zhong Zheng, Richard E. Lee, Bernd Meibohm, Pavan K. Vaddady, Jianjun Qi, Sourav Das, Samanthi L. Waidyarachchi, David F. Bruhn, Helena I. Boshoff, Michael S. Scherman, Dianqing Sun, Mercedes Gonzalez-Juarrero, Tanja Matt, Chetan Rathi, Anne J. Lenaerts, Ashit Trivedi
Publikováno v:
Nature medicine
Although the classical antibiotic spectinomycin is a potent bacterial protein synthesis inhibitor, poor antimycobacterial activity limits its clinical application for treating tuberculosis. Using structure-based design, we generated a new semisynthet