Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Robin A. Weinberg"'
Autor:
Martin Hegen, David C. Wood, Patrik Rhönnstad, Felix Vajdos, Atli Thorarensen, Mark E. Schnute, Timothy Braden, Kimberly Crouse, Maria Sjöberg, John I. Trujillo, Ravi G. Kurumbail, Bolette Husman, Konrad F. Koehler, Mattias Wennerstål, Tomas Bonn, Joakim Löfstedt, Eva Backström-Rydin, Bo Carlsson, Aron Sundell, Ming Z. Chen, Steven E. Heasley, John David Trzupek, Annika Goos-Nilsson, Carol A. Menard, Peter Harris, James R. Kiefer, Martin Bengtsson, Leon P. Collis, Michael J. Prinsen, Philippe Nuhant, Jennifer Alley, Scott A. Long, Alexander E. Hromockyj, Andrew C. Flick, Johnny Sandberg, Christoph W. Zapf, Edouard Zamaratski, Xiao Hu, Lee Napierata, Björn Kauppi, Nicole Caspers, Kimberly F. Fennell, Robert E. Kyne, Gabriel Berstein, Neelu Kaila, Lars Kruger, Wei Li, Li Xing, Ray Unwalla, Elisabet Kallin, Matthew J. Pelc, Susan Fish, James Robert Blinn, Hjalmar Gullberg, Marvin J. Meyers, Scot Richard Mente, Chulho Choi, Falgun Shah, Mathias Färnegårdh, Dean Messing, Peter G. Jones, Yajuan Zhao, Alexandria P. Taylor, Maria Sandström, Charles W. Bolten, Daniel Nöteberg, Robin A. Weinberg, Tomasz Janosik, John D. Knafels, Anna Wilhelmsson
Publikováno v:
Journal of medicinal chemistry. 61(23)
The nuclear hormone receptor retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) is a promising target for the treatment of autoimmune diseases. A small molecule, inverse agonist of the receptor is anticipated to reduce production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b335f732a3ffd4d00a80bd0f813c732
https://pubmed.ncbi.nlm.nih.gov/30130103
https://pubmed.ncbi.nlm.nih.gov/30130103
Autor:
James R. Kiefer, Joseph W. Leone, Alfredo G. Tomasselli, Robin A. Weinberg, Akshay Patny, H. David Fischer, Cynthia D. Sommers, Jennifer A. Gormley, Timothy E. Benson, Horng-Chih Huang, E.J. Jacobsen, Jacqueline E. Day, Thomas L. Emmons, Jill Chrencik, Iris K. Leung, Jeffrey L. Hirsch, Tenbrink Ruth E, Jennifer M. Williams, Brian Korniski, Troii Hall
Publikováno v:
Journal of Molecular Biology. 400:413-433
Janus kinases (JAKs) are critical regulators of cytokine pathways and attractive targets of therapeutic value in both inflammatory and myeloproliferative diseases. Although the crystal structures of active JAK1 and JAK2 kinase domains have been repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b19fab0c9dc63112be2b1f9f66fc065
https://doi.org/10.1016/j.jmb.2010.05.020
https://doi.org/10.1016/j.jmb.2010.05.020
Autor:
Thomas L. Emmons, Alfredo G. Tomasselli, Robin A. Weinberg, H. David Fischer, Jill Chrencik, Brian Korniski, Jacqueline E. Day, Stacy Brown, Joseph W. Leone, Ann D. Wrightstone, Cynthia D. Sommers, Jeffrey L. Hirsch, Arthur J. Wittwer, Troii Hall, Jennifer A. Gormley
Publikováno v:
Biochemical and Biophysical Research Communications. 396:543-548
The Janus kinase family consists of four members: JAK-1, -2, -3 and TYK-2. While JAK-2 and JAK-3 have been well characterized biochemically, there is little data on TYK-2. Recent work suggests that TYK-2 may play a critical role in the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4568dae04b1e101103ca4b31d2d17487
https://doi.org/10.1016/j.bbrc.2010.04.141
https://doi.org/10.1016/j.bbrc.2010.04.141
Autor:
Thomas L. Emmons, James R. Kiefer, Joseph W. Leone, John F. Schindler, Melissa S. Harris, Jacqueline E. Day, Siradanahalli Guru, Alfredo G. Tomasselli, Robin A. Weinberg, Sandra Lightle, H. David Fischer, Jeffrey L. Hirsch, Jill Chrencik, Jennifer A. Gormley, Jennifer M. Williams, Matthew J. Saabye, Troii Hall
Publikováno v:
Protein Expression and Purification. 69:54-63
Janus-associated kinases (JAKs) play critical roles in cytokine signaling, and have emerged as viable therapeutic targets in inflammation and oncology related diseases. To date, targeting JAK proteins with highly selective inhibitor compounds have re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68adb1eba9066345bc1000db1eef31a2
https://doi.org/10.1016/j.pep.2009.09.011
https://doi.org/10.1016/j.pep.2009.09.011
Autor:
Rob Hills, Robin A. Weinberg, Thomas P. Kasten, Beverly A. Reitz, Jaime L. Masferrer, Robert A. Pufahl, James K. Gierse
Publikováno v:
Analytical Biochemistry. 364:204-212
Leukotrienes are important mediators in a number of inflammatory diseases and therefore are a target of several therapeutic approaches. The first committed step in the synthesis of leukotrienes is the conversion of arachidonic acid to leukotriene A(4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12ee570c709786c1a173079c7efe50e
https://doi.org/10.1016/j.ab.2007.02.009
https://doi.org/10.1016/j.ab.2007.02.009
Autor:
Troii Hall, Catherine S. Tripp, Bryan F. Kilpatrick, Beverly A. Reitz, Carol M. Koboldt, Cindy Sommers, Rodney G. Combs, Hymavathi Boddupalli, Jennifer L. Pierce, Q. Khai Huynh, Sharon A. Rouw, Robin A. Weinberg, Scott D. Hauser, Becky L. Hood, Judy A. Diaz-Collier
Publikováno v:
Journal of Biological Chemistry. 275:25883-25891
Nuclear factor kappa B (NF-kappaB) is a ubiquitous, inducible transcription factor that regulates the initiation and progression of immune and inflammatory stress responses. NF-kappaB activation depends on phosphorylation and degradation of its inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b22aa869e2c4f4a40e73ba43cbda7da2
https://doi.org/10.1074/jbc.m000296200
https://doi.org/10.1074/jbc.m000296200
Autor:
Robin A. Weinberg, Charles A. McWherter, Jeffrey I. Gordon, David C. Wood, Stephen C. Lee, Sandra K. Freeman
Publikováno v:
Molecular Microbiology. 16:241-250
MyristoylCoA:protein N-myristoyltransferase (Nmt) catalyses the co-translational, covalent attachment of myristate (C14:0) to the amino-terminal glycine residue of a number of eukaryotic proteins involved in cellular growth and signal transduction. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c21e317ee3623ad66f99fba833fc818
https://doi.org/10.1111/j.1365-2958.1995.tb02296.x
https://doi.org/10.1111/j.1365-2958.1995.tb02296.x
Autor:
Alfredo G. Tomasselli, Robin A. Weinberg, H. David Fischer, Lyle E. Pegg, Ann D. Wrightstone, Cynthia D. Sommers, Stacy Brown, Thomas L. Emmons, Arthur J. Wittwer, Eric T. Baima, Jeffrey L. Hirsch
Publikováno v:
Protein and peptide letters. 19(5)
The Janus kinase (JAK) family consists of four members: JAK-1, -2, -3 and tyrosine kinase 2 (TYK-2). Recent work suggests that cytokine signaling through TYK-2 may play a critical role in a number of inflammatory processes. We recently described the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe4a1b316bfa5b6ee01547811330368
https://pubmed.ncbi.nlm.nih.gov/22486643
https://pubmed.ncbi.nlm.nih.gov/22486643
Autor:
Olga V. Nemirovskiy, Authur Wittwer, Konstantine Beltey, Jaime L. Masferrer, Michael P. Murphy, Robin A. Weinberg, Jay M. Wendling, Atli Thorarensen, Mark E. Schnute, Matthew James Pelc, Erica L. Bradshaw-Pierce, Ben S. Zweifel, Amy Johnston, Steve Wene, Lyle E. Pegg, Michael J. Prinsen, Shinji Ogawa, James K. Gierse, Troii Hall, Luz Cortes-Burgos
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 334(1)
Autotaxin is the enzyme responsible for the production of lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC), and it is up-regulated in many inflammatory conditions, including but not limited to cancer, arthritis, and multiple sclerosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dad205d237643d6ef84e3da8309c17f
https://pubmed.ncbi.nlm.nih.gov/20392816
https://pubmed.ncbi.nlm.nih.gov/20392816
Autor:
Sumathy Mathialagan, Jill Chrencik, Scott S. Woodard, Nandini Kishore, Julia A. Guzova, Robin A. Weinberg, Shaun R. Selness, Eric T. Baima, Gabriel Mbalaviele, John F. Schindler, Sheri L. Bonar, Lily R.-H. Song, Medora M. Hardy, William F. Hood, Eva E. Nagiec
Publikováno v:
The Journal of Biological Chemistry
The classical nuclear factor kappaB (NF-kappaB) signaling pathway is under the control of the IkappaB kinase (IKK) complex, which consists of IKK-1, IKK-2, and NF-kappaB essential modulator (NEMO). This complex is responsible for the regulation of ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0554c30fdfc058636a2f89f8139d732c
https://pubmed.ncbi.nlm.nih.gov/20167598
https://pubmed.ncbi.nlm.nih.gov/20167598