Platinum-loaded, selenium-doped hydroxyapatite nanoparticles selectively reduce proliferation of prostate and breast cancer cells co-cultured in the presence of stem cells

Autor: Nicola Margiotta, Jeroen J.J.P. van den Beucken, Sander C.G. Leeuwenburgh, Lorenzo Degli Esposti, Robin A. Nadar, Alessandra Barbanente, Michele Iafisco, Barbara Palazzo

Publikováno v: Journal of Materials Chemistry B 8 (2020): 2792–2804. doi:10.1039/d0tb00390e
info:cnr-pdr/source/autori:Barbanente, Alessandra; Nadar, Robin A.; Degli Esposti, Lorenzo; Palazzo, Barbara; Iafisco, Michele; van den Beucken, Jeroen J. J. P.; Leeuwenburgh, Sander C. G.; Margiotta, Nicola/titolo:Platinum-loaded, selenium-doped hydroxyapatite nanoparticles selectively reduce proliferation of prostate and breast cancer cells co-cultured in the presence of stem cells/doi:10.1039%2Fd0tb00390e/rivista:Journal of Materials Chemistry B/anno:2020/pagina_da:2792/pagina_a:2804/intervallo_pagine:2792–2804/volume:8
Journal of Materials Chemistry B, 8, 2792-2804
Journal of Materials Chemistry B, 8, 14, pp. 2792-2804

Chemotherapeutic treatment of patients with bone tumors or bone metastases often leads to severe side effects such as high drug toxicity, lack of tumor specificity and induced drug resistance. A novel strategy to treat early stages of bone metastases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad4b406e03e7499b69badeeb27be18c
https://doi.org/10.1039/d0tb00390e

Thermoresponsive Brushes Facilitate Effective Reinforcement of Calcium Phosphate Cements

Autor: Sander C.G. Leeuwenburgh, Ali Paknahad, Daniela-Geta Petre, Yingfeng Tu, Robin A. Nadar, Daniela A. Wilson

Publikováno v: Acs Applied Materials & Interfaces., 11, 30, pp. 26690-26703
ACS Applied Materials & Interfaces
Acs Applied Materials & Interfaces., 11, 26690-26703
ACS applied materials & interfaces, 11(30)

Calcium phosphate ceramics are frequently applied to stimulate regeneration of bone in view of their excellent biological compatibility with bone tissue. Unfortunately, these bioceramics are also highly brittle. To improve their toughness, fibers can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d8660292941b5e4648a60d2451588f
https://doi.org/10.1021/acsami.9b08311

Bone tumor-targeted delivery of theranostic Pt-195m-bisphosphonate complexes promotes killing of metastatic tumor cells

Autor: J.J.J.P van den Beucken, Egbert Oosterwijk, Sandra Heskamp, N.W.M. Van Dijk, Gerben M. Franssen, Sander C.G. Leeuwenburgh, Nicola Margiotta, Michele Iafisco, M. De Weijert, K. Codee-van der Schilden, Robin A. Nadar

Publikováno v: Materials Today Bio, 9
Materials today bio 9 (2021). doi:10.1016/j.mtbio.2020.100088
info:cnr-pdr/source/autori:Nadar R.A.; Franssen G.M.; Van Dijk N.W.M.; Codee-van der Schilden K.; de Weijert M.; Oosterwijk E.; Iafisco M.; Margiotta N.; Heskamp S.; van den Beucken J.J.J.P.; Leeuwenburgh S.C.G./titolo:Bone tumor-targeted delivery of theranostic 195mPt-bisphosphonate complexes promotes killing of metastatic tumor cells/doi:10.1016%2Fj.mtbio.2020.100088/rivista:Materials today bio/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:9
Materials Today Bio, Vol 9, Iss, Pp 100088-(2021)

Platinum-based drugs such as cisplatin are very potent chemotherapeutics, whereas radioactive platinum (195mPt) is a rich source of low-energy Auger electrons, which kills tumor cells by damaging DNA. Auger electrons damage cells over a very short ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e00664209c12e98287384036842ef0

Targeting of radioactive platinum-bisphosphonate anticancer drugs to bone of high metabolic activity

Autor: Otto C. Boerman, Sandra Heskamp, Uwe Karst, Nicola Margiotta, Michele Iafisco, Michael Brand, Martin Bornhaeuser, Karlijn Codee-van der Schilden, Nandini Asokan, Barbara Crone, Robin A. Nadar, Sander C.G. Leeuwenburgh, Kambiz Farbod, Alessandra Curci, Jeroen J.J.P. van den Beucken, Lukas Schlatt

Publikováno v: Scientific Reports
Scientific Reports, 10
Scientific reports (Nature Publishing Group) 10 (2020). doi:10.1038/s41598-020-62039-2
info:cnr-pdr/source/autori:Nadar, Robin A.; Farbod, Kambiz; Codee-van der Schilden, Karlijn; Schlatt, Lukas; Crone, Barbara; Asokan, Nandini; Curci, Alessandra; Brand, Michael; Bornhaeuser, Martin; Iafisco, Michele; Margiotta, Nicola; Karst, Uwe; Heskamp, Sandra; Boerman, Otto C.; van den Beucken, Jeroen J. J. P.; Leeuwenburgh, Sander C. G./titolo:Targeting of radioactive platinum-bisphosphonate anticancer drugs to bone of high metabolic activity/doi:10.1038%2Fs41598-020-62039-2/rivista:Scientific reports (Nature Publishing Group)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)

Platinum-based chemotherapeutics exhibit excellent antitumor properties. However, these drugs cause severe side effects including toxicity, drug resistance, and lack of tumor selectivity. Tumor-targeted drug delivery has demonstrated great potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d7e7c905a9014f0fc7e87c4b67eae5
http://europepmc.org/articles/PMC7125202

Contributors

Autor: Taufiq Ahmad, Hamdan Alghamdi, Ali Alghamdi, Faez Saleh Al-Hamed, Khalid Al-Motari, Susanne Bierbaum, Vincent M.J.I. Cuijpers, Anna Diez-Escudero, Montserrat Espanol, Maria-Pau Ginebra, Jason L. Guo, Vera Hintze, Alain Hoornaert, Johanna F.A. Husch, John A. Jansen, Pierre Layrolle, Sangmin Lee, Sander C.G. Leeuwenburgh, Sajeesh Kumar Madhurakkat Perikamana, Alaa Mansour, Faleh Tamimi Marino, Antonios G. Mikos, Robin A. Nadar, Omar Omar, Anders Palmquist, Trenton C. Piepergerdes, Sundar Ramalingam, Krisztina Ruscsák, Shariel Sayardoust, Dieter Scharnweber, Furqan A. Shah, Heungsoo Shin, Chalini Sundar, Peter Thomsen, Jesus Torres, Jeroen J.J.P. van den Beucken, X. Frank Walboomers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::761485ca23bff39402c1fec905950910
https://doi.org/10.1016/b978-0-08-102478-2.09992-x