Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Robin A. Carr"'
Publikováno v:
Cancer Research. 83:2635-2635
Introduction: There is a need for ADC payloads with an improved therapeutic index, consequently we have coupled potent and selective inhibitors of NMT to trastuzumab to test their potential in both in vitro and in vivo models. Experimental Procedures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9611e1ac42535e4fc107e4cf799e64fc
https://doi.org/10.1158/1538-7445.am2023-2635
https://doi.org/10.1158/1538-7445.am2023-2635
Autor:
M. Pass, J. R. Wheatcroft, Harry Finch, N. Bailey, P. Shah, J. E. Head, Robin E. Carr, B. Evans, J. W. B. Cooke, P. C. Box
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:281-286
The development of a potent, selective and orally bioavailable 1,5-benzodiazepindione gastrin/CCKB receptor antagonist (compound 7, GR199114X) is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ef0204400d241624832f84087598e56
https://doi.org/10.1016/s0960-894x(96)00613-0
https://doi.org/10.1016/s0960-894x(96)00613-0
Publikováno v:
Tetrahedron Letters. 37:5163-5166
Generation of azomethine ylides, imidate methylides, and thioimidate methylides which are exocyclic to indane, benzofuran, benzothiophene, and benzopyran moieties respectively, in the presence of electron deficient dipolarophiles, gives direct access
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db99460eab09c9c1187aa0b6b48054dc
https://doi.org/10.1016/0040-4039(96)01026-x
https://doi.org/10.1016/0040-4039(96)01026-x
Publikováno v:
Tetrahedron Letters. 37:3915-3918
The γ-lactam based alkaloid cynometrine has been synthesised in four steps from 1-methyl-imidazole-4-carboxaldehyde. The key step involves an efficient regio-, stereo-, and chemoselective 1,3-dipolar cycloaddition of a dithiolane-fused azomethine yl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef0eca34317c5995e2a902a957d11ee7
https://doi.org/10.1016/0040-4039(96)00688-0
https://doi.org/10.1016/0040-4039(96)00688-0
Publikováno v:
Tetrahedron Letters. 37:711-714
Dithiolane-isocyanate imminium methylides which are a new type of azomethine methylide-derived 1,3-dipole undergo efficient and regioselective cycloaddition to conjugated carbonyls and thiocarbonyls to yield predominantly 1,3-oxazolidine- and thiazol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29d9162260e99389f42bd3dd5bc90e7a
https://doi.org/10.1016/0040-4039(95)02249-x
https://doi.org/10.1016/0040-4039(95)02249-x
Publikováno v:
Tetrahedron Letters. 36:9409-9412
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0d839ba29e99a8953d3562344dfcb9c
https://doi.org/10.1016/0040-4039(95)01998-w
https://doi.org/10.1016/0040-4039(95)01998-w
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58daaedcbf7f1d50162810329b9d43fe
https://doi.org/10.1002/chin.199615133
https://doi.org/10.1002/chin.199615133
Publikováno v:
ChemInform. 27
Dithiolane-isocyanate imminium methylides which are a new type of azomethine methylide-derived 1,3-dipole undergo efficient and regioselective cycloaddition to conjugated carbonyls and thiocarbonyls to yield predominantly 1,3-oxazolidine- and thiazol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd06533477896cc46d03b0cf8f181779
https://doi.org/10.1002/chin.199618127
https://doi.org/10.1002/chin.199618127
Publikováno v:
ChemInform. 27
The γ-lactam based alkaloid cynometrine has been synthesised in four steps from 1-methyl-imidazole-4-carboxaldehyde. The key step involves an efficient regio-, stereo-, and chemoselective 1,3-dipolar cycloaddition of a dithiolane-fused azomethine yl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c42c2275034f60d3429e3d56723a68f2
https://doi.org/10.1002/chin.199638222
https://doi.org/10.1002/chin.199638222
Publikováno v:
ChemInform. 27
Generation of azomethine ylides, imidate methylides, and thioimidate methylides which are exocyclic to indane, benzofuran, benzothiophene, and benzopyran moieties respectively, in the presence of electron deficient dipolarophiles, gives direct access
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da15442d0415cb1729cf6507e215feda
https://doi.org/10.1002/chin.199643083
https://doi.org/10.1002/chin.199643083