Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T

Autor: Julian Mevenkamp, Yvonne M. H. Bruls, Rodrigo Mancilla, Lotte Grevendonk, Joachim E. Wildberger, Kim Brouwers, Matthijs K. C. Hesselink, Patrick Schrauwen, Joris Hoeks, Riekelt H. Houtkooper, Mijke Buitinga, Robin A. de Graaf, Lucas Lindeboom, Vera B. Schrauwen-Hinderling

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract NADH and NAD+ act as electron donors and acceptors and NAD+ was shown to stimulate mitochondrial biogenesis and metabolic health. We here develop a non-invasive Phosphorous Magnetic Resonance Spectroscopy (31P-MRS) method to quantify these m

Externí odkaz: https://doaj.org/article/641cc9cbaffb4da5a60ddf4d1b9cf383

Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI)

Autor: Kevan L. Ip, Monique A. Thomas, Kevin L. Behar, Robin A. de Graaf, Henk M. De Feyter

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

IntroductionThere is a lack of robust metabolic imaging techniques that can be routinely applied to characterize lesions in patients with brain tumors. Here we explore in an animal model of glioblastoma the feasibility to detect uptake and metabolism

Externí odkaz: https://doaj.org/article/81dfcb7338494a788f1ad7f628406912

In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging

Autor: Anu E Meerwaldt, Milou Straathof, Wija Oosterveld, Caroline L van Heijningen, Mandy MT van Leent, Yohana C Toner, Jazz Munitz, Abraham JP Teunissen, Charlotte C Daemen, Annette van der Toorn, Gerard van Vliet, Geralda AF van Tilborg, Henk M De Feyter, Robin A de Graaf, Elly M Hol, Willem JM Mulder, Rick M Dijkhuizen

Publikováno v: Journal of cerebral blood flow and metabolism. Nature Publishing Group
Journal of Cerebral Blood Flow and Metabolism, 43, 5, pp. 778-790
Journal of Cerebral Blood Flow and Metabolism, 43, 778-790
Journal of Cerebral Blood Flow and Metabolism, 43(5), 778-790. Nature Publishing Group

Contains fulltext : 291902.pdf (Publisher’s version ) (Open Access) Recanalization therapy after acute ischemic stroke enables restoration of cerebral perfusion. However, a significant subset of patients has poor outcome, which may be caused by dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a321148a761c90eca8229409b2516451
https://doi.org/10.1177/0271678x221148970

Measurement of neuro‐energetics and neurotransmission in the rat olfactory bulb using 1 H and 1 H–[ 13 C] NMR spectroscopy

Autor: Golam M. I. Chowdhury, Kevin L. Behar, Graeme F. Mason, Douglas L. Rothman, Robin A. de Graaf

Publikováno v: NMR in Biomedicine.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2301c0abaef3cc78de6b5b7f179b6c75
https://doi.org/10.1002/nbm.4957

Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics

Autor: Yury Koush, Douglas L Rothman, Kevin L Behar, Robin A de Graaf, Fahmeed Hyder

Publikováno v: J Cereb Blood Flow Metab

While functional MRI (fMRI) localizes brain activation and deactivation, functional MRS (fMRS) provides insights into the underlying metabolic conditions. There is much interest in measuring task-induced and resting levels of metabolites implicated i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a4c68a56db9df5864f83629d7f92da
https://doi.org/10.1177/0271678x221076570