Výsledky vyhledávání - "Robin A Raymer"

Akademický článek

Preclinical evaluation of a next-generation, subcutaneously administered, coagulation factor IX variant, dalcinonacog alfa.

Autor: Timothy C Nichols, Howard Levy, Elizabeth P Merricks, Robin A Raymer, Martin L Lee

Publikováno v: PLoS ONE, Vol 15, Iss 10, p e0240896 (2020)

IntroductionThe rapid clearance of factor IX necessitates frequent intravenous administrations to achieve effective prophylaxis for patients with hemophilia B. Subcutaneous administration has historically been limited by low bioavailability and poten

Externí odkaz: https://doaj.org/article/8c741e748a044c79abe6c6f6c0a7ee4e

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Akademický článek

Oxidized LDL and Fructosamine Associated with Severity of Coronary Artery Atherosclerosis in Insulin Resistant Pigs Fed a High Fat/High NaCl Diet.

Autor: Timothy C Nichols, Elizabeth P Merricks, Dwight A Bellinger, Robin A Raymer, Jing Yu, Diana Lam, Gary G Koch, Walker H Busby, David R Clemmons

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132302 (2015)

Insulin-resistant subjects develop more severe and diffuse coronary artery atherosclerosis than insulin-sensitive controls but the mechanisms that mediate this atherosclerosis phenotype are unknown.To determine the metabolic parameters that associate

Externí odkaz: https://doaj.org/article/fdaeeb58e3ea435d8c46bdfab0fc23c5

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Mechanical Anisotropy Assessment in Kidney Cortex Using ARFI Peak Displacement: Preclinical Validation and Pilot In Vivo Clinical Results in Kidney Allografts

Autor: Elizabeth P. Merricks, Lauren E. Wimsey, Emily H. Chang, Melissa C. Caughey, Murad Hossain, Caterina M. Gallippi, Timothy C. Nichols, Robin A. Raymer, Margaret H Whitford, Dwight A. Bellinger, Melrose Fisher, Randal K. Detwiler

Publikováno v: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 66:551-562

The kidney is an anisotropic organ, with higher elasticity along versus across nephrons. The degree of mechanical anisotropy in the kidney may be diagnostically relevant if properly exploited; however, if improperly controlled, anisotropy may confoun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10ff9bf2f69b008edd382ff01afb601b
https://doi.org/10.1109/tuffc.2018.2865203

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Preclinical evaluation of a next-generation, subcutaneously administered, coagulation factor IX variant, dalcinonacog alfa

Autor: Elizabeth P. Merricks, Martin Lee, Robin A. Raymer, Howard Levy, Timothy C. Nichols

Publikováno v: PLoS ONE
PloS one, vol 15, iss 10
PLoS ONE, Vol 15, Iss 10, p e0240896 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb365fb9c001109890d8e527a0233004
https://pubmed.ncbi.nlm.nih.gov/33112889

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Oral Tolerance Induction in Hemophilia B Dogs Fed with Transplastomic Lettuce

Autor: Timothy C. Nichols, Henry Daniell, Elizabeth P. Merricks, Alexandra Sherman, Bei Zhang, Mattias Häger, George Q. Perrin, Jin Su, Roland W. Herzog, Bo Wiinberg, Robin A. Raymer

Publikováno v: Molecular Therapy. 25(2):512-522

Anti-drug antibodies in hemophilia patients substantially complicate treatment. Their elimination through immune tolerance induction (ITI) protocols poses enormous costs, and ITI is often ineffective for factor IX (FIX) inhibitors. Moreover, there is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af9b3c29bd06ce2710db787d05c76fd

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Soy Phosphatidylinositol–Containing Lipid Nanoparticle Prolongs the Plasma Survival and Hemostatic Efficacy of B-domain–Deleted Recombinant Canine Factor VIII in Hemophilia A Dogs

Autor: Sathy V. Balu-Iyer, Krithika A. Shetty, Natalie Rigsbee, Elizabeth P. Merricks, Timothy C. Nichols, Robin A. Raymer

Publikováno v: Journal of Pharmaceutical Sciences. 105:2459-2464

Soy phosphatidylinositol (PI)-containing lipid nanoparticles prolong plasma survival, improve hemostatic efficacy, and decrease immunogenicity of human B-domain-deleted factor VIII (BDD FVIII) in hemophilia A (HA) mice. We hypothesize that PI-associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad94dfac0fcbd7d7d599750a3a256d0f
https://doi.org/10.1016/j.xphs.2016.05.023

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Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII

Autor: Katherine A. High, Paris Margaritis, Timothy C. Nichols, Robin A. Raymer, Shannon M. Smith, Giulia Pavani, Shangzhen Zhou, Dwight A. Bellinger, Oscar A. Marcos-Contreras, Armida Faella, Elizabeth P. Merricks

Publikováno v: Blood. 127:565-571

Factor VII (FVII) deficiency is a rare autosomal recessive bleeding disorder treated by infusion of fresh-frozen plasma, plasma-derived FVII concentrates and low-dose recombinant activated FVII. Clinical data suggest that a mild elevation of plasma F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626919b0ac28fc8515222abac7d8f427
https://doi.org/10.1182/blood-2015-09-671420

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In vivo mechanical anisotropy assessment in renal cortex using ARFI peak displacement

Autor: Margaret H Whitford, Robin A. Raymer, Elizabeth P. Merricks, Bellinger Dwight, Caterina M. Gallippi, Melissa C. Caughey, Randal K. Detwiler, Melrose Fisher, Murad Hossain, Timothy C. Nichols, Lauren Whimsey, Emily H. Chang

Publikováno v: 2017 IEEE International Ultrasonics Symposium (IUS).

The kidney is an anisotropic organ, with higher elasticity along versus across nephrons. The degree of elastic anisotropy in kidney may be diagnostically relevant if properly exploited; however, if improperly controlled, anisotropy may confound stiff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c5889e6b923a6e71512e59193613c20
https://doi.org/10.1109/ultsym.2017.8092413

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Severe Hemophilia A in a Male Old English Sheep Dog with a C→T Transition that Created a Premature Stop Codon in Factor VIII

Autor: Jay N, Lozier, Mark T, Kloos, Elizabeth P, Merricks, Nathaly, Lemoine, Margaret H, Whitford, Robin A, Raymer, Dwight A, Bellinger, Timothy C, Nichols

Publikováno v: Comparative medicine. 66(5)

Animals with hemophilia are models for gene therapy, factor replacement, and inhibitor development in humans. We have actively sought dogs with severe hemophilia A that have novel factor VIII mutations unlike the previously described factor VIII intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6932642667bddb68b7193d3225c03ed
https://pubmed.ncbi.nlm.nih.gov/27780008

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Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models

Autor: Robert A. French, Timothy C. Nichols, Shanzhen Zhou, Robin A. Raymer, Benjamin J. Samelson-Jones, Julie M. Crudele, Valder R. Arruda, Benjamin J. Lee, Elizabeth P. Merricks, Rodney M. Camire, Joshua I. Siner

Processing by the proprotein convertase furin is believed to be critical for the biological activity of multiple proteins involved in hemostasis, including coagulation factor VIII (FVIII). This belief prompted the retention of the furin recognition m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46fc652be8a11c165dc71aa6e2c92bb0
https://europepmc.org/articles/PMC5053153/

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