Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Robin A, Fairhurst"'
Autor:
David A. Sykes, Mireia Jiménez‐Rosés, John Reilly, Robin A. Fairhurst, Steven J. Charlton, Dmitry B. Veprintsev
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract In this study, we report the β1‐adrenoceptor binding kinetics of several clinically relevant β1/2‐adrenoceptor (β1/2AR) agonists and antagonists. [3H]‐DHA was used to label CHO‐β1AR for binding studies. The kinetics of ligand bin
Externí odkaz:
https://doaj.org/article/23a0dbaf85364a89ad9273ace3affdf9
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Activity of FGF401 in biochemical kinase assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de614aa92fc53e000078388a9034229
https://doi.org/10.1158/1535-7163.22506502.v1
https://doi.org/10.1158/1535-7163.22506502.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Details on materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855b9cca12680f3ffc27bb3edd85e4d5
https://doi.org/10.1158/1535-7163.22506505.v1
https://doi.org/10.1158/1535-7163.22506505.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
PK and PK/PD of FGF401 in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a8adc6be4db10400fb7b3afdb43e38
https://doi.org/10.1158/1535-7163.22506514.v1
https://doi.org/10.1158/1535-7163.22506514.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
This file provides the full characterization of FGF401
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3a6190c2b2732e54abfeea8a8dd793
https://doi.org/10.1158/1535-7163.22506520
https://doi.org/10.1158/1535-7163.22506520
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and it is the third leading cause of cancer-related deaths worldwide. Recently, aberrant signaling through the FGF19/FGFR4 axis has been implicated in HCC. Here, we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13e8f6230bcc0ef53c3f3f3f81212e3c
https://doi.org/10.1158/1535-7163.c.6538417.v1
https://doi.org/10.1158/1535-7163.c.6538417.v1
Autor:
Robin A. Fairhurst, Pascal Furet, Patricia Imbach-Weese, Frédéric Stauffer, Heinrich Rueeger, Clive McCarthy, Sebastien Ripoche, Susanne Oswald, Bertrand Arnaud, Aline Jary, Michel Maira, Christian Schnell, Daniel A. Guthy, Markus Wartmann, Michael Kiffe, Sandrine Desrayaud, Francesca Blasco, Toni Widmer, Frank Seiler, Sascha Gutmann, Mark Knapp, Giorgio Caravatti
Publikováno v:
Journal of Medicinal Chemistry. 65:8345-8379
Balanced pan-class I phosphoinositide 3-kinase inhibition as an approach to cancer treatment offers the prospect of treating a broad range of tumor types and/or a way to achieve greater efficacy with a single inhibitor. Taking buparlisib as the start
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a308bfc3e4d7e6ca0655f9bedbe9796
https://doi.org/10.1021/acs.jmedchem.2c00267
https://doi.org/10.1021/acs.jmedchem.2c00267
Autor:
Christelle Stamm, Pierre Nimsgern, Thomas Knoepfel, Jasmin Wirth, Michel Niklaus, Diana Graus-Porta, Alberto Del Rio Espinola, Dario Sterker, Michael Kiffe, Nicolas Warin, Van Huy Luu, Mario Madoerin, Robert Mah, Jacqueline Kinyamu-Akunda, Robin Alec Fairhurst, Milen Todorov, Nicole Buschmann, Sebastien Ripoche, Nils Ostermann, Inga Galuba, Philippe Couttet, Catherine Leblanc, Alexandra Buhles, Jutta Blank, Flavia Adler, Wolfgang Jahnke, Chao Zou, Joerg Berghausen, Andreas Weiss, Pascal Furet, Heiko Schadt, Johannes Voshol, Markus Wartmann, Joerg Trappe
Publikováno v:
Journal of Medicinal Chemistry. 63:12542-12573
FGF19 signaling through the FGFR4/β-klotho receptor complex has been shown to be a key driver of growth and survival in a subset of hepatocellular carcinomas, making selective FGFR4 inhibition an attractive treatment opportunity. A kinome-wide seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e8386d5d1c6ff60ee10d825b90d6de
https://doi.org/10.1021/acs.jmedchem.0c01019
https://doi.org/10.1021/acs.jmedchem.0c01019
Autor:
David A. Sykes, Steven J. Charlton, John Reilly, Dmitry B. Veprintsev, Robin Alec Fairhurst, Mireia Jiménez-Rosés
In this study, we report the β1-adrenoceptor binding kinetics of several clinically relevant β1/2-adrenoceptor (β1/2AR) agonists and antagonists. We demonstrate that the physicochemical properties of a molecule directly affect its kinetic associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::065ce31f32613d2fe60719a6c668d76c
https://doi.org/10.1101/2021.08.31.458064
https://doi.org/10.1101/2021.08.31.458064
Autor:
Dean F. Rigel, Berengere Dumotier, Brian Peter Richardson, Thomas Ullrich, Moise Azria, Estelle Lach-Trifilieff, Shinji Hatakeyama, David J. Glass, Julian Bösch, David A. Sykes, Michael Kiffe, Ngoc-Hong Nguyen, Jeffrey Tsao, Steven J. Charlton, Magdalena Koziczak-Holbro, Robin Alec Fairhurst, Marie Jourdain, Ludivine Flotte, Yuichiro Adachi
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:188-199
The anabolic effects of β2-adrenoceptor (β2-AR) agonists on skeletal muscle have been demonstrated in various species. However, the clinical use of β2-AR agonists for skeletal muscle wasting conditions has been limited by their undesired cardiovas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6da56dc65829abdb607bc5857ac885a8
https://doi.org/10.1124/jpet.118.255307
https://doi.org/10.1124/jpet.118.255307