Dose escalation of tolinapant (ASTX660) in combination with standard radical chemoradiotherapy in cervical cancer : a study protocol for a phase 1b TiTE-CRM clinical trial (CRAIN) in UK secondary care centres

Autor: Peter Hoskin, Marina Lee, Denise Dunkley, Mary Danh, Robin Wickens, Geoff Saunders, Josh Northey, Simon Crabb, Vicky McFarlane, Azmat Sadozye, Rachel Cooper, Tony Mathew, Kate Haslett, Kim Reeves, Rachel Reed, Kamilla Bigos, Kaye J. Williams, Emily Rowling, Ananya Choudhury, Sonia Dancer, Deb Smith, Gareth Griffiths

Publikováno v: BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)

Abstract Background Cervical cancer is the fourth most common cancer in women, with an estimated 342,000 deaths worldwide in 2020. Current standard of care in the UK for locally advanced cervical cancer is concurrent chemoradiotherapy with weekly cis

Externí odkaz: https://doaj.org/article/f7ea589d3ca34f57b9365cb0b9d214d5

Evaluating atezolizumab in patients with urinary tract squamous cell carcinoma (AURORA): study protocol for a single arm, open-label, multicentre, phase II clinical trial

Autor: Simon Crabb, Robin Wickens, Sarah Jane-Bibby, Denise Dunkley, Megan Lawrence, Allen Knight, Robert Jones, Alison Birtle, Robert Huddart, Mark Linch, Jonathan Martin, Adam Coleman, Konstantinos Boukas, Hannah Markham, Gareth Griffiths

Publikováno v: BMC Cancer, Vol 23, Iss 1, Pp 1-11 (2023)

Abstract Background Bladder and urinary tract cancers account for approximately 21,000 new diagnoses and 5,000 deaths annually in the UK. Approximately 90% are transitional cell carcinomas where advanced disease is treated with platinum based chemoth

Externí odkaz: https://doaj.org/article/883dd092ab0e4728b9ca62b8a51e9be0

Embedding qualitative research in lung cancer trials: Thoracic Umbrella Radiotherapy Study in stage IV NSCLC: TOURIST

Autor: Lynn Calman, Amy Hancock, Caroline Lee, Robin Wickens, Joanna Hack, Chris Sutton, Andrea Corkhill, Izabella Eberhart, Kayleigh Hill, Sean Ewings, Elizabeth Camacho, Merina Ahmed, Janette Rawlinson, Jacqui Gath, Crispin Hiley, Gareth Griffiths, David Woolf, Matthew Hatton

Publikováno v: Lung Cancer. 178:S88

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76839f1d9cdb4af08e14676d86274bb0
https://doi.org/10.1016/s0169-5002(23)00624-4

Repeated daily administration of increasing doses of lipopolysaccharide provides a model of sustained inflammation-induced depressive-like behaviour in mice that is independent of the NLRP3 inflammasome

Autor: Luc Ver Donck, Robin Wickens, Amanda B. Mackenzie, Sarah J. Bailey

Publikováno v: Wickens, R A, Ver Donck, L, Mackenzie, A B & Bailey, S J 2018, ' Repeated daily administration of increasing doses of lipopolysaccharide provides a model of sustained inflammation-induced depressive-like behaviour in mice that is independent of the NLRP3 inflammasome ', Behavioural Brain Research, vol. 352, pp. 99-108 . https://doi.org/10.1016/j.bbr.2017.07.041

Mounting preclinical evidence has implicated the NLRP3 inflammasome in depression-related behaviours elicited by chronic stress or acute lipopolysaccharide (LPS) challenge. However, the relevance of acute LPS as a model of depression has been questio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab0efb835d5d3b14a4041ed14eb9d6a
https://pubmed.ncbi.nlm.nih.gov/28760701

Lesions of the dorsomedial striatum impair formation of attentional set in rats

Autor: Hanna S. Lindgren, Stephen B. Dunnett, Robin Wickens, Verity J. Brown, David S. Tait

Publikováno v: Neuropharmacology. 71

Behavioural flexibility refers to the ability to rapidly adapt to novel situations and it has been suggested that the frontal lobe and basal ganglia are implicated in various components of adjusting to changes in environmental contingencies. Behaviou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c601948171d12eba2647b46b631580ae
https://pubmed.ncbi.nlm.nih.gov/23583929