Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Robin, Striar"'
Autor:
Tewodros Mulugeta Dagnew, Chieh-En J. Tseng, Chi-Hyeon Yoo, Meena M. Makary, Anna E. Goodheart, Robin Striar, Tyler N. Meyer, Anna K. Rattray, Leyi Kang, Kendall A. Wolf, Stephanie A. Fiedler, Darcy Tocci, Hannah Shapiro, Scott Provost, Eleanor Sultana, Yan Liu, Wei Ding, Ping Chen, Marek Kubicki, Shiqian Shen, Ciprian Catana, Nicole R. Zürcher, Hsiao-Ying Wey, Jacob M. Hooker, Roger D. Weiss, Changning Wang
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110159- (2024)
Summary: Alcohol use disorder (AUD) is a disorder of clinical and public health significance requiring novel and improved therapeutic solutions. Both environmental and genetic factors play a significant role in its pathophysiology. However, the under
Externí odkaz:
https://doaj.org/article/103a05e692354997b207d886b6310c5d
Autor:
Ping Bai, Yu Lan, Hao Wang, Zude Chen, Stephanie Fiedler, Robin Striar, Xiaoxia Lu, Changning Wang
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Bromodomain and extra-terminal domain (BET) family proteins have become a hot research area because of their close relationship with a variety of human diseases. The non-invasive imaging technique, such as positron emission tomography (PET), provides
Externí odkaz:
https://doaj.org/article/a7cb2edc0fcf4e0c8ad1817b14a70e72
Autor:
Anna Goodheart, Chi-Hyeon Yoo, Robin Striar, Moqing Quan, Hsiao-Ying Wey, Changning Wang, Stephen Gomperts
Publikováno v:
Thursday, April 27.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::805520e81423fe7692a4ef8d2d7113d6
https://doi.org/10.1212/wnl.0000000000203708
https://doi.org/10.1212/wnl.0000000000203708
Autor:
Alisa M. Posner, Robin Striar, Anna Kathryn Rattray, Rudolph E. Tanzi, Changning Wang, Tyler Nicholas Meyer, Sepideh Afshar, Ping Bai, Shiqian Shen, Yan Liu, Can Zhang, Yu Lan, Amelia G. Langan
Publikováno v:
J Med Chem
We report the development of the first positron emission tomography (PET) radiotracer, [(18)F]CNY-07, based on a highly specific and potent RIPK1 inhibitor, Nec-1s, for RIPK1/necroptosis brain imaging in rodents. [(18)F]CNY-07 was synthesized through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c6846c1adf50b54d2cda4841ca2da5
https://doi.org/10.1021/acs.jmedchem.1c01477
https://doi.org/10.1021/acs.jmedchem.1c01477
Autor:
Gengyang Yuan, Darcy R. Tocci, Changning Wang, Stephen J. Haggarty, Zude Chen, Yan Liu, Hao Wang, Amelia G. Langan, Julia S. Zagaroli, Ping Bai, Robin Striar, Yu Lan, Sepideh Afshar, Debasis Patnaik
Publikováno v:
Journal of Medicinal Chemistry. 64:14745-14756
To better understand the role of bromodomain and extra-terminal domain (BET) proteins in epigenetic mechanisms, we developed a series of thienodiazepine-based derivatives and identified two compounds, 3a and 6a, as potent BET inhibitors. Further in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38570b8605bfa1284c7fb16eb837d610
https://doi.org/10.1021/acs.jmedchem.1c01323
https://doi.org/10.1021/acs.jmedchem.1c01323
Autor:
David Groshar, Jennifer Y. Wo, Motaz Qadan, Krista E Suarez-Weiss, James C. Cusack, Heike E. Daldrup-Link, Ricciardi Rocco, Amirkasra Mojtahed, Robin Striar, Liliana Bordeianou, Lale Umutlu, Felipe S. Furtado, Mark Anderson, Mark Vangel, Onofrio A. Catalano, Cristina R. Ferrone, Lawrence S. Blaszkowsky, Theodore S. Hong, Jeffrey W. Clark
Publikováno v:
Br J Cancer
Background Oligometastatic colorectal cancer (CRC) is potentially curable and demands individualised strategies. Methods This single-centre retrospective study investigated if positron emission tomography (PET)/magnetic resonance imaging (MR) had a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fe61725b6d6ee5cb8176ab2e67d206
https://doi.org/10.1038/s41416-021-01494-8
https://doi.org/10.1038/s41416-021-01494-8
Autor:
Yu Lan, Yan Liu, Robin Striar, Changning Wang, Stephanie A. Fiedler, Ping Bai, Hao Wang, Xiaoxia Lu
Publikováno v:
ACS Med Chem Lett
[Image: see text] In this paper, we report the design, synthesis, and biological evaluation of the first selective bromodomain and extra-terminal domain (BET) BD1 bromodomains of the PET radiotracer [(18)F]PB006. The standard compound PB006 showed hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe4f4d81b0d30cf7803a64b4c275858
https://doi.org/10.1021/acsmedchemlett.0c00650
https://doi.org/10.1021/acsmedchemlett.0c00650
Autor:
David Groshar, Robin Striar, Jennifer Y. Wo, Liliana Bordeianou, Felipe S. Furtado, David P. Ryan, Umar Mahmood, Lina Garcia Cañamaque, Marco Salvatore, Lale Umutlu, Andrea Soricelli, Bruce R. Rosen, Jeffrey W. Clark, Hiroko Kunitake, David H. Berger, Lawrence S. Blaszkowsky, Onofrio A. Catalano, Chiara Anna Parente, Yan Li, Susanna I. Lee, Rocco Ricciardi, Theodore S. Hong, Christy E. Cauley
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 48:1235-1245
The role of positron emission tomography/magnetic resonance (PET/MR) in evaluating the local extent of rectal cancer remains uncertain. This study aimed to investigate the possible role of PET/MR versus magnetic resonance (MR) in clinically staging r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d0c78b61437bc4a1806d64cb1b31ec
https://doi.org/10.1007/s00259-020-05036-x
https://doi.org/10.1007/s00259-020-05036-x
Autor:
Stephanie A. Fiedler, Ping Bai, Shenglin Luo, Yu Lan, Zude Chen, Robin Striar, Yulong Xu, Hao Wang, Changning Wang
Publikováno v:
Medicinal Chemistry Research. 29:2106-2111
Enhancer of zeste homolog 2 (EZH2) is responsible for the methylation of lysine 27 of histone H3 (H3K27) leading to transcriptional repression. Consequently, EZH2 is related with several diseases including cancers, as overexpressed EZH2 can down-regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bdf7b838411c6408ee644f8db90e2d3
https://doi.org/10.1007/s00044-020-02633-1
https://doi.org/10.1007/s00044-020-02633-1
Autor:
Jing Yang, Huabiao Chen, Hao Wang, Ping Bai, Chongzhao Ran, Zude Chen, Yulong Xu, Robin Striar, Xiashuang Wang, Bo Xiang, Xiaoshuang Yang, Hong Li, Robert E. Koegel, Gengyang Yuan, Daniela R. Bernales, Qi Cao, Stephanie A. Fiedler, Changning Wang, Tao Li, Yu Yang
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 48:53-66
Castration-resistant prostate cancer (CRPC) is the most common cause of death in men. The effectiveness of HDAC inhibitors has been demonstrated by preclinical models, but not in clinical studies, probably due to the ineffectively accumulation of HDA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46f313854840ca33ece2d0bd4a0e3f3e
https://doi.org/10.1007/s00259-020-04896-7
https://doi.org/10.1007/s00259-020-04896-7