Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Robin, Dowell"'
Autor:
Faye M. Walker, Lays Martin Sobral, Etienne Danis, Bridget Sanford, Sahiti Donthula, Ilango Balakrishnan, Dong Wang, Angela Pierce, Sana D. Karam, Soudabeh Kargar, Natalie J. Serkova, Nicholas K. Foreman, Sujatha Venkataraman, Robin Dowell, Rajeev Vibhakar, Nathan A. Dahl
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Dynamic regulation of gene expression is fundamental for cellular adaptation to exogenous stressors. P-TEFb-mediated pause-release of RNA polymerase II (Pol II) is a conserved regulatory mechanism for synchronous transcriptional induction in
Externí odkaz:
https://doaj.org/article/d56159185f7f4564adf980120f3ab2ba
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0307375 (2024)
Heat shock stress induces genome-wide changes in transcription regulation, activating a coordinated cellular response to enable survival. We noticed many heat shock genes are up-regulated in blood samples from individuals with trisomy 21. We characte
Externí odkaz:
https://doaj.org/article/e9b62ee5f1034911aaaac0be0f2acd27
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
Aging is defined as the functional decline of tissues and organisms, leading to many human conditions, such as cancer, neurodegenerative diseases, and hair loss. Although stem cell exhaustion is widely recognized as a hallmark of aging, our understan
Externí odkaz:
https://doaj.org/article/8c963f1371584994b519ba1cce749750
Autor:
Cierra J. Walker, Dilara Batan, Carrie T. Bishop, Daniel Ramirez, Brian A. Aguado, Megan E. Schroeder, Claudia Crocini, Jessica Schwisow, Karen Moulton, Laura Macdougall, Robert M. Weiss, Mary A. Allen, Robin Dowell, Leslie A. Leinwand, Kristi S. Anseth
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 3, Pp n/a-n/a (2022)
Abstract Aortic valve stenosis (AVS) is a progressive fibrotic disease that is caused by thickening and stiffening of valve leaflets. At the cellular level, quiescent valve interstitial cells (qVICs) activate to myofibroblasts (aVICs) that persist wi
Externí odkaz:
https://doaj.org/article/7131e16927834fb5a636e98358625fa7
Autor:
Richard A Radcliffe, Robin Dowell, Aaron T Odell, Phillip A Richmond, Beth Bennett, Colin Larson, Katerina Kechris, Laura M Saba, Pratyaydipta Rudra, Shi Wen
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240253 (2020)
We have been using the Inbred Long- and Short-Sleep mouse strains (ILS, ISS) and a recombinant inbred panel derived from them, the LXS, to investigate the genetic underpinnings of acute ethanol tolerance which is considered to be a risk factor for al
Externí odkaz:
https://doaj.org/article/6bb75906b5b144df8a17c8cbb8047c09
Autor:
Pamela H. Russell, Brian Vestal, Wen Shi, Pratyaydipta D. Rudra, Robin Dowell, Richard Radcliffe, Laura Saba, Katerina Kechris
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-8 (2018)
Abstract Objective Many tools have been developed to profile microRNA (miRNA) expression from small RNA-seq data. These tools must contend with several issues: the small size of miRNAs, the small number of unique miRNAs, the fact that similar miRNAs
Externí odkaz:
https://doaj.org/article/e0937fcb46a64206992d70cc09decbbe
Autor:
Faye M. Walker, Lays Martin Sobral, Etienne Danis, Bridget Sanford, Ilango Balakrishnan, Dong Wang, Angela Pierce, Sana D. Karam, Natalie J. Serkova, Nicholas K. Foreman, Sujatha Venkataraman, Robin Dowell, Rajeev Vibhakar, Nathan A. Dahl
Publikováno v:
bioRxiv
Dynamic regulation of gene expression is fundamental for cellular adaptation to exogenous stressors. PTEFb-mediated pause-release of RNA polymerase II (Pol II) is a conserved regulatory mechanism for synchronous transcriptional induction in response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9133983a3a420710c3c9efbfe2987363
https://europepmc.org/articles/PMC9900817/
https://europepmc.org/articles/PMC9900817/
Sample mapping information for GRO-seq datasets used in the study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c488367501ad475a71c2fb895c9864
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174052 (2017)
BACKGROUND:The RNA binding proteins (RBPs) human antigen R (HuR) and Tristetraprolin (TTP) are known to exhibit competitive binding but have opposing effects on the bound messenger RNA (mRNA). How cells discriminate between the two proteins is an int
Externí odkaz:
https://doaj.org/article/f4debd7f733b434ab961917efbf0a2bc
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175988 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0174052.].
Externí odkaz:
https://doaj.org/article/7c4c7b5bf80d4cfe8935e6879c3898a0