Výsledky vyhledávání - "Robier Aguillon-Prada"

Double-blind randomized proof-of-concept trial of canakinumab in patients with COVID-19 associated cardiac injury and heightened inflammation

Autor: Robier Aguillon Prada, David Wolinsky, Venu Menon, Prabalini Rajendram, Steven E. Nissen, Tom Kai Ming Wang, Debasis Sahoo, A. Michael Lincoff, Paul Cremer, Danielle M. Brennan, Siddharth Dugar, Jamie Hernandez-Montfort, Abhijit Duggal, Daniel A. Culver, Ossama K. Abou Hassan, Calvin C Sheng, Katherine E. Wolski

Publikováno v: European Heart Journal Open. 1

Aims In coronavirus disease 2019 (COVID-19), myocardial injury is associated with systemic inflammation and higher mortality. Our aim was to perform a proof of concept trial with canakinumab, a monoclonal antibody to interleukin-1β, in patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694db93ff3ad56e8cc25405410359c8d
https://doi.org/10.1093/ehjopen/oeab002

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Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trial

Autor: Abhijit Duggal, Qiuqing Wang, Jeannie Celiberti, Tisha S. Wang, Bruce C. Trapnell, James Young, Calvin C Sheng, Alison Montpetit, Jennifer Coehlo, Catherine Owen, Aldo Bonaventura, Joan Greer, Herbert Wiedemann, Any Ladd, Brian Mandell, Randy Perrin, Yub Raj Sedhai, Jill Kandrac, Fang Fang, Paul Cremer, Leslie Korbee, Steven Gordon, Christina Sewell, Annie Partisano, Ai Chen Ho, Joyce O'Brine, Brenna Carey, Benjamin W. Van Tassell, Robier Aguillon Prada, Prabalini Rajendram, Antonio Abbate, Denise Kosty Sweeny, Virginia Mihalick, Alice Goyanes, Kristin Hudock, Craig Balog, Steven Y. Chang, Stephanie Spencer, Carla McWilliams, Mary Pal, Dave Nichols, Jinesh Mehta, Alessandra Vecchié, John F. Paolini, Deborah Gladish, Katherine E. Wolski, Siddharth Dugar, Nicole Hummel, Debasis Sahoo, Yuki Kuramochi, George Wohlford, Anna Priday, Karen Myers

Publikováno v: The Lancet. Rheumatology

Summary Background In patients with COVID-19, granulocyte-macrophage colony stimulating factor (GM-CSF) might be a mediator of the hyperactive inflammatory response associated with respiratory failure and death. We aimed to evaluate whether mavrilimu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87871686d52b464d750d28744dabdc5d
https://pubmed.ncbi.nlm.nih.gov/33754144

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Canakinumab to reduce deterioration of cardiac and respiratory function in SARS-CoV-2 associated myocardial injury with heightened inflammation (canakinumab in Covid-19 cardiac injury: The three C study)

Autor: Ossama K. Abou Hassan, Prabalini Rajendram, Tom Kai Ming Wang, Venu Menon, Robier Aguillon Prada, Siddharth Dugar, Steven E. Nissen, A. Michael Lincoff, Paul Cremer, Calvin C Sheng, Abhijit Duggal, Debasis Sahoo, Daniel A. Culver, Danielle M. Brennan

Publikováno v: Clinical Cardiology

Background In patients with Covid-19, myocardial injury and increased inflammation are associated with morbidity and mortality. We designed a proof-of-concept randomized controlled trial to evaluate whether treatment with canakinumab prevents progres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdf89b61bf220abdcd507a7140a0244
https://pubmed.ncbi.nlm.nih.gov/32830894

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Cyclodextrin Protects Podocytes in Diabetic Kidney Disease

Publikováno v: Diabetes

Diabetic kidney disease (DKD) remains the most common cause of end-stage kidney disease despite multifactorial intervention. We demonstrated that increased cholesterol in association with downregulation of ATP-binding cassette transporter ABCA1 occur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11322a7ed9bbee8ccc1274e57b3ec50
https://doi.org/10.2337/db13-0399

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FGF23 induces left ventricular hypertrophy

Publikováno v: Journal of Clinical Investigation. 121:4393-4408

Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiovascular disease in individuals with CKD. Elevated levels of FG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88581f824a89705cf527991ae1070a3
https://doi.org/10.1172/jci46122

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Rituximab Targets Podocytes in Recurrent Focal Segmental Glomerulosclerosis

Autor: Carolyn Abitbol, Linda Chen, Camillo Ricordi, Masami Ikehata, Jing Li, Adela Mattiazzi, Changli Wei, Gaston Zilleruelo, Robier Aguillon-Prada, Wacheree Seeherunvong, Gaetano Ciancio, Jochen Reiser, Junichiro Sageshima, Jayanthi Chandar, Maria Pia Rastaldi, Alexandra Jauregui, Sandra Merscher-Gomez, George W. Burke, Alessia Fornoni

Publikováno v: Science Translational Medicine. 3

Focal segmental glomerulosclerosis (FSGS) is a prevalent glomerular disease characterized by proteinuria, progression to end stage renal disease and recurrence of proteinuria after kidney transplantation in approximately one third of patients. It has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad967d6a493c150b223fdaf529522b0e
https://doi.org/10.1126/scitranslmed.3002231

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Ad-ISF35 Intratumoral Administration Induces a Bystander Effect and Immune-Mediated Tumor Rejection with a Safe Vector Biodistribution and Toxicology Profile In a NHL Mouse Model

Autor: Robier Aguillon-Prada, Thomas J. Kipps, Mauricio Urquiza, Johanna Melo-Cardenas, Januario E. Castro

Publikováno v: Blood. 116:1470-1470

Abstract 1470 Ad-ISF35 is a replication-defective adenovirus (Ad) vector encoding a membrane-stable chimeric CD154 (ISF35) that can induce expression of costimulatory and death receptor molecules in chronic lymphocytic leukemia (CLL) cells in vitro a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9b3d2c24622be7d1d32f7dfe8e78262
https://doi.org/10.1182/blood.v116.21.1470.1470

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