Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients.

Autor: Robicsek, O¹, Karry, R¹, Petit, I², Salman-Kesner, N³, Müller, F-J⁴, Klein, E¹, Aberdam, D², Ben-Shachar, D¹

Publikováno v: Molecular Psychiatry. Oct2013, Vol. 18 Issue 10, p1067-1076. 10p.

Induced pluripotent stem cells from hair follicles as a cellular model for neurodevelopmental disorders

Autor: Dorit Ben-Shachar, Edith Aberdam, Robicsek O, Daniel Aberdam, N. Salman Kesner, Rachel Karry, Franz-Josef Müller, Isabelle Petit

Publikováno v: Stem Cell Research. 8(1):134-140

Disease-specific induced pluripotent stem cells (iPSC) allow unprecedented experimental platforms for basic research as well as high-throughput screening. This may be particularly relevant for neuropsychiatric disorders, in which the affected neurona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc808893b3159788b7377ba2b6f2fbf

MITOCHONDRIAL DYSFUNCTION PLAYS A ROLE IN IMPAIRED NEURONAL DIFFERENTIATION IN SCHIZOPHRENIA

Autor: Robicsek O, Dorit Ben-Shachar, Hila Ene, Rachel Karry

Publikováno v: European Neuropsychopharmacology. 27:S517

Schizophrenia (SZ) is conceptualized as a neurodevelopmental disorder, involving dysfunction of dopaminergic and glutamatergic systems as well as of mitochondria. Among the major obstacles in studying pathological processes in SZ are the inaccessibil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::035662a52164a1fb96d1dfecbe8b0925
https://doi.org/10.1016/j.euroneuro.2016.09.632

Isolated Mitochondria Transfer Improves Neuronal Differentiation of Schizophrenia-Derived Induced Pluripotent Stem Cells and Rescues Deficits in a Rat Model of the Disorder.

Autor: Robicsek O; Laboratory of Psychobiology, Department of Psychiatry, Rambam Health Care Campus, B. Rappaport Faculty of Medicine and Rappaport Family Institute for Research in Medical Sciences, Technion IIT, Haifa, Israel., Ene HM; Laboratory of Psychobiology, Department of Psychiatry, Rambam Health Care Campus, B. Rappaport Faculty of Medicine and Rappaport Family Institute for Research in Medical Sciences, Technion IIT, Haifa, Israel., Karry R; Laboratory of Psychobiology, Department of Psychiatry, Rambam Health Care Campus, B. Rappaport Faculty of Medicine and Rappaport Family Institute for Research in Medical Sciences, Technion IIT, Haifa, Israel., Ytzhaki O; Laboratory of Psychobiology, Department of Psychiatry, Rambam Health Care Campus, B. Rappaport Faculty of Medicine and Rappaport Family Institute for Research in Medical Sciences, Technion IIT, Haifa, Israel., Asor E; Laboratory of Psychobiology, Department of Psychiatry, Rambam Health Care Campus, B. Rappaport Faculty of Medicine and Rappaport Family Institute for Research in Medical Sciences, Technion IIT, Haifa, Israel., McPhie D; Department of Psychiatry, Harvard Medical School, Boston, McLean Hospital, Belmont, MA., Cohen BM; Department of Psychiatry, Harvard Medical School, Boston, McLean Hospital, Belmont, MA., Ben-Yehuda R; School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel., Weiner I; School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Ben-Shachar D; Laboratory of Psychobiology, Department of Psychiatry, Rambam Health Care Campus, B. Rappaport Faculty of Medicine and Rappaport Family Institute for Research in Medical Sciences, Technion IIT, Haifa, Israel.

Publikováno v: Schizophrenia bulletin [Schizophr Bull] 2018 Feb 15; Vol. 44 (2), pp. 432-442.

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