Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Robia G. Pautler"'
Autor:
Donna M. Peehl, Cristian T. Badea, Thomas L. Chenevert, Heike E. Daldrup-Link, Li Ding, Lacey E. Dobrolecki, A. McGarry Houghton, Paul E. Kinahan, John Kurhanewicz, Michael T. Lewis, Shunqiang Li, Gary D. Luker, Cynthia X. Ma, H. Charles Manning, Yvonne M. Mowery, Peter J. O'Dwyer, Robia G. Pautler, Mark A. Rosen, Raheleh Roudi, Brian D. Ross, Kooresh I. Shoghi, Renuka Sriram, Moshe Talpaz, Richard L. Wahl, Rong Zhou
Publikováno v:
Tomography, Vol 9, Iss 2, Pp 657-680 (2023)
The availability of high-fidelity animal models for oncology research has grown enormously in recent years, enabling preclinical studies relevant to prevention, diagnosis, and treatment of cancer to be undertaken. This has led to increased opportunit
Externí odkaz:
https://doaj.org/article/315dd791b13b4c40966ef7abc8d61d4c
Autor:
Dariya Malyarenko, Ghoncheh Amouzandeh, Stephen Pickup, Rong Zhou, Henry Charles Manning, Seth T. Gammon, Kooresh I. Shoghi, James D. Quirk, Renuka Sriram, Peder Larson, Michael T. Lewis, Robia G. Pautler, Paul E. Kinahan, Mark Muzi, Thomas L. Chenevert
Publikováno v:
Tomography, Vol 9, Iss 1, Pp 375-386 (2023)
Relevant to co-clinical trials, the goal of this work was to assess repeatability, reproducibility, and bias of the apparent diffusion coefficient (ADC) for preclinical MRIs using standardized procedures for comparison to performance of clinical MRIs
Externí odkaz:
https://doaj.org/article/9222f4abb7d4458ca75182c703cf97ac
Autor:
Jordan Kho, Urszula Polak, Ming-Ming Jiang, John D. Odom, Jill V. Hunter, Saima M. Ali, Lindsay C. Burrage, Sandesh C.S. Nagamani, Robia G. Pautler, Hannah P. Thompson, Akihiko Urayama, Zixue Jin, Brendan Lee
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Nitric oxide (NO) is a critical signaling molecule that has been implicated in the pathogenesis of neurocognitive diseases. Both excessive and insufficient NO production have been linked to pathology. Previously, we have shown that argininosuccinate
Externí odkaz:
https://doaj.org/article/6775588bb4dc4e2abf6ec0fb79c6a418
Autor:
Hui J. Wang, Chang Seok Lee, Rachel Sue Zhen Yee, Linda Groom, Inbar Friedman, Lyle Babcock, Dimitra K. Georgiou, Jin Hong, Amy D. Hanna, Joseph Recio, Jong Min Choi, Ting Chang, Nadia H. Agha, Jonathan Romero, Poonam Sarkar, Nicol Voermans, M. Waleed Gaber, Sung Yun Jung, Matthew L. Baker, Robia G. Pautler, Robert T. Dirksen, Sheila Riazi, Susan L. Hamilton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse
Externí odkaz:
https://doaj.org/article/1dca01fbb1744c91925d570cd3ada4fa
Autor:
Shannon E. Ronca, Sarah M. Gunter, Rebecca Berry Kairis, Allison Lino, Jonathan Romero, Robia G. Pautler, Alan Nimmo, Kristy O. Murray
Publikováno v:
Viruses, Vol 14, Iss 9, p 1961 (2022)
Of individuals who develop West Nile neuroinvasive disease (WNND), ~10% will die and >40% will develop long-term complications. Current treatment recommendations solely focus on supportive care; therefore, we urgently need to identify novel and effec
Externí odkaz:
https://doaj.org/article/8e43812094944629baab67fd46d17f70
Autor:
Lindsay C. Fadel, Ivany V. Patel, Jonathan Romero, I-Chih Tan, Shelli R. Kesler, Vikram Rao, S. A. Amali S. Subasinghe, Russell S. Ray, Jason T. Yustein, Matthew J. Allen, Brian W. Gibson, Justin J. Verlinden, Stanley Fayn, Nicole Ruggiero, Caitlyn Ortiz, Elizabeth Hipskind, Aaron Feng, Chijindu Iheanacho, Alex Wang, Robia G. Pautler
Publikováno v:
Biosensors, Vol 12, Iss 8, p 616 (2022)
Anesthesia is often used in preclinical imaging studies that incorporate mouse or rat models. However, multiple reports indicate that anesthesia has significant physiological impacts. Thus, there has been great interest in performing imaging studies
Externí odkaz:
https://doaj.org/article/e3590e0019ec447e8aabbbe88387c59e
Autor:
S. A. Amali S. Subasinghe, Robia G. Pautler, Md. Abul Hassan Samee, Jason T. Yustein, Matthew J. Allen
Publikováno v:
Biosensors, Vol 12, Iss 7, p 478 (2022)
Hypoxia in solid tumors is associated with poor prognosis, increased aggressiveness, and strong resistance to therapeutics, making accurate monitoring of hypoxia important. Several imaging modalities have been used to study hypoxia, but each modality
Externí odkaz:
https://doaj.org/article/970438b413ce4edeafe17fe702187c1f
Autor:
Michela Palmieri, Rituraj Pal, Hemanth R. Nelvagal, Parisa Lotfi, Gary R. Stinnett, Michelle L. Seymour, Arindam Chaudhury, Lakshya Bajaj, Vitaliy V. Bondar, Laura Bremner, Usama Saleem, Dennis Y. Tse, Deepthi Sanagasetti, Samuel M. Wu, Joel R. Neilson, Fred A. Pereira, Robia G. Pautler, George G. Rodney, Jonathan D. Cooper, Marco Sardiello
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis. Here authors show that trehalose, an mTOR-independent autophagy inducer, alleviates the pathological phenotypes in a mouse model of neurodegenerative disease. Trehalose
Externí odkaz:
https://doaj.org/article/9d01b8cdb7714197a5184f986c9a6f8a
Autor:
Ann P. Quick, BA, Andrew P. Landstrom, MD, PhD, Qiongling Wang, PhD, David L. Beavers, MD, PhD, Julia O. Reynolds, BS, Giselle Barreto-Torres, PhD, Viet Tran, MD, Jordan Showell, BS, Leonne E. Philippen, MSc, Shaine A. Morris MD, MPH, Darlene Skapura, BS, J. Martijn Bos, MD, Steen E. Pedersen, PhD, Robia G. Pautler, PhD, Michael J. Ackerman, MD, PhD, Xander H.T. Wehrens, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 1, Pp 56-67 (2017)
Summary: Junctophilin-2 (JPH2) is a structural calcium (Ca2+) handling protein, which approximates the cardiomyocyte transverse tubules (TTs) to the sarcoplasmic reticulum. This facilitates communication of the voltage-gated Ca2+ channel and the ryan
Externí odkaz:
https://doaj.org/article/d086c9c35bcd4a099db4e3951cde466e
Autor:
Bibiana K Y Wong, Jaclyn B Murry, Rajesh Ramakrishnan, Fang He, Alfred Balasa, Gary R Stinnett, Steen E Pedersen, Robia G Pautler, Ignatia B Van den Veyver
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224876 (2019)
Gene-environment interactions contribute to the risk for Autism Spectrum Disorder (ASD). Among environmental factors, prenatal exposure to stress may increase the risk for ASD. To examine if there is an interaction between exposure to maternal stress
Externí odkaz:
https://doaj.org/article/c9f844e4a110406e8057fcb7eafb711d