Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Robi Tacutu"'
Autor:
Dmitri Toren, Hagai Yanai, Reem Abu Taha, Gabriela Bunu, Eugen Ursu, Rolf Ziesche, Robi Tacutu, Vadim E Fraifeld
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Tissue fibrosis is a major driver of pathology in aging and is involved in numerous age-related diseases. The lungs are particularly susceptible to fibrotic pathology which is currently difficult to treat. The mouse bleomycin-induced fibrosi
Externí odkaz:
https://doaj.org/article/6f385b81d7a846bd95a98ccaec205d2d
Autor:
Roberto A. Avelar, Javier Gómez Ortega, Robi Tacutu, Eleanor J. Tyler, Dominic Bennett, Paolo Binetti, Arie Budovsky, Kasit Chatsirisupachai, Emily Johnson, Alex Murray, Samuel Shields, Daniela Tejada-Martinez, Daniel Thornton, Vadim E. Fraifeld, Cleo L. Bishop, João Pedro de Magalhães
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases. Many genes play a role in cellular senescence, yet a comprehensiv
Externí odkaz:
https://doaj.org/article/7b84219b475d4993ae23863cf7f41947
Autor:
Simona Ghenea, Marioara Chiritoiu, Robi Tacutu, Antonio Miranda-Vizuete, Stefana Maria Petrescu
Publikováno v:
PLoS Genetics, Vol 18, Iss 2, p e1010069 (2022)
EDEM-1, EDEM-2 and EDEM-3 are key players for the quality control of newly synthesized proteins in the endoplasmic reticulum (ER) by accelerating disposal and degradation of misfolded proteins through ER Associated Degradation (ERAD). Although many p
Externí odkaz:
https://doaj.org/article/4faf25871f044cfb9e78bf3cecbbe3bd
Autor:
Anton, Kulaga, Olga, Borysova, Alexey, Karmazin, Maria, Koval, Nikolay, Usanov, Alina, Fedorova, Sergey, Evfratov, Malvina, Pushkareva, Kim, Ryangguk, Robi, Tacutu
Genomic data has become increasingly accessible to the general public with the advent of companies offering whole genome sequencing at a relatively low cost. However, their reports are not verifiable due to a lack of crucial details and transparency:
Externí odkaz:
http://arxiv.org/abs/2403.19087
Publikováno v:
Network Biology, Vol 1, Iss 2, Pp 112-120 (2011)
Although different aspects of cancer immunity are a subject of intensive investigation, an integrative view on the possible molecular links between immunoregulators and cancer-associated genes has not yet been fully considered. In an attempt to get m
Externí odkaz:
https://doaj.org/article/64be81afe7b54cda8e59c3b1691a9a44
Autor:
Robi Tacutu, David E Shore, Arie Budovsky, João Pedro de Magalhães, Gary Ruvkun, Vadim E Fraifeld, Sean P Curran
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48282 (2012)
Intricate and interconnected pathways modulate longevity, but screens to identify the components of these pathways have not been saturating. Because biological processes are often executed by protein complexes and fine-tuned by regulatory factors, th
Externí odkaz:
https://doaj.org/article/235eff5c410c4ffc809e0b3280203fe9
Autor:
Anna Knyazer, Gabriela Bunu, Dmitri Toren, Teodora Bucaciuc Mracica, Yael Segev, Marina Wolfson, Khachik K. Muradian, Robi Tacutu, Vadim E. Fraifeld
Publikováno v:
Aging (Albany NY)
If somatic stem cells would be able to maintain their regenerative capacity over time, this might, to a great extent, resolve rejuvenation issues. Unfortunately, the pool of somatic stem cells is limited, and they undergo cell aging with a consequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5263134f32db68b8cd9e8043d74b4db4
https://doi.org/10.18632/aging.203791
https://doi.org/10.18632/aging.203791
Autor:
Dmitri Toren, Simona Ghenea, Vimbai Netsai Charity Samukange, Gabriela Bunu, Robi Tacutu, Ioan Valentin Matei
Publikováno v:
Aging (Albany NY)
Genetic manipulations can ameliorate the aging process and extend the lifespan of model organisms. The aim of this research was to identify novel genetic interventions that promote both lifespan and healthspan, by combining the effects of multiple lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d7d16667e2592f4749338c1c373a3b
http://europepmc.org/articles/PMC8457566
http://europepmc.org/articles/PMC8457566
Age-related pathologies are so widely presented in old age that in most cases they are hardly distinguishable at the molecular level from the so-called ‘‘normal’’ aging. Both aging and age-related diseases are characterized by a wide range of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::790923d95554c9afaa5ea9b1dbd4927b
https://doi.org/10.1101/2022.11.01.514657
https://doi.org/10.1101/2022.11.01.514657
Publikováno v:
Applied Intelligence. 51:2456-2470
In this paper, we propose a method of learning representation layers with squashing activation functions within a deep artificial neural network which directly addresses the vanishing gradients problem. The proposed solution is derived from solving t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::195bf9c9c88116bfca95fbb9327036a0
https://doi.org/10.1007/s10489-020-02032-4
https://doi.org/10.1007/s10489-020-02032-4