Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy in a CTCF-dependent manner

Autor: Silvia Peripolli, Leticia Meneguello, Chiara Perrod, Tanya Singh, Harshil Patel, Sazia T. Rahman, Koshiro Kiso, Peter Thorpe, Vincenzo Calvanese, Cosetta Bertoli, Robertus A. M. de Bruin

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract Oncogene-induced replication stress is a crucial driver of genomic instability and one of the key events contributing to the onset and evolution of cancer. Despite its critical role in cancer, the mechanisms that generate oncogene-induced re

Externí odkaz: https://doaj.org/article/3465e31efc2e4d63bc650aa1d9a692b2

Vaccinia Virus Arrests and Shifts the Cell Cycle

Autor: Caroline K. Martin, Jerzy Samolej, Annabel T. Olson, Cosetta Bertoli, Matthew S. Wiebe, Robertus A. M. de Bruin, Jason Mercer

Publikováno v: Viruses, Vol 14, Iss 2, p 431 (2022)

Modulation of the host cell cycle is a common strategy used by viruses to create a pro-replicative environment. To facilitate viral genome replication, vaccinia virus (VACV) has been reported to alter cell cycle regulation and trigger the host cell D

Externí odkaz: https://doaj.org/article/13452384b490479aa944c0a205c72470

Oncogenic c-Myc activity increases tolerance to proteotoxic and genotoxic stress through regulation of HSF1

Autor: Joe Jones, Koshiro Kiso, Cosetta Bertoli, Robertus A. M. de Bruin

Oncogenes, such as c-Myc, enhance growth and proliferative signaling to promote continuous cell cycle divisions, the hallmark of cancer. The inadvertent consequence of this is an increase in cellular stresses. However, whether and how oncogenes can d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98b58c46b8d11beb76ccf3ed873f4b66
https://doi.org/10.1101/2022.02.02.478796

The proteasome controls ESCRT-III–mediated cell division in an archaeon

Autor: Sian Bray, Siân Culley, Anđela Šarić, Gautam Dey, Gabriel Tarrason Risa, Catherine Fan, Delyan R. Mutavchiev, Robertus A. M. de Bruin, Ricardo Henriques, Luca Pellegrini, Anne E. Hafner, Lena Harker-Kirschneck, Mairi L. Kilkenny, Fredrik Hurtig, Buzz Baum, Colin Davis, Dimitra Papatziamou, Ann-Christin Lindås, Ambrosius P. Snijders, Leticia Meneguello, André A. Pulschen, Nicholas P. Robinson, Peter Faull, Diorge P. Souza

Publikováno v: Science

Proteasomal control of division in Archaea In eukaryotes, proteasome-mediated degradation of cell cycle factors triggers mitotic exit, DNA segregation, and cytokinesis, a process that culminates in abscission dependent on the protein ESCRT-III. By st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d492ef9cf289e7440840d230cd2d2a3
https://doi.org/10.1126/science.aaz2532

A G1‐like state allows HIV ‐1 to bypass SAMHD 1 restriction in macrophages

Autor: Petra Mlcochova, Katherine A. Sutherland, Alexandra Chittka, Christiana Georgiou, Gina M. Lenzi, Mahdad Noursadeghi, Stuart J. D. Neil, Sarah A. Watters, Robertus A. M. de Bruin, Asim Khwaja, Simon Yona, Baek Kim, Cosetta Bertoli, Jan Rehwinkel, Greg J. Towers, Matthew C. Gage, Ravindra K. Gupta

Publikováno v: Mlcochova, P, Sutherland, K A, Watters, S A, Bertoli, C, de Bruin, R A M, Rehwinkel, J, Neil, S J, Lenzi, G M, Kim, B, Khwaja, A, Gage, M C, Georgiou, C, Chittka, A, Yona, S, Noursadeghi, M, Towers, G J & Gupta, R K 2017, ' A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages ', The EMBO journal, vol. 36, no. 5, pp. 604-616 . https://doi.org/10.15252/embj.201696025
The EMBO Journal

An unresolved question is how HIV‐1 achieves efficient replication in terminally differentiated macrophages despite the restriction factor SAMHD1. We reveal inducible changes in expression of cell cycle‐associated proteins including MCM2 and cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b827e597ca2e337f38562406fc199183
https://doi.org/10.15252/embj.201696025