Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Robertus A M, de Bruin"'
Autor:
Silvia Peripolli, Leticia Meneguello, Chiara Perrod, Tanya Singh, Harshil Patel, Sazia T. Rahman, Koshiro Kiso, Peter Thorpe, Vincenzo Calvanese, Cosetta Bertoli, Robertus A. M. de Bruin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Oncogene-induced replication stress is a crucial driver of genomic instability and one of the key events contributing to the onset and evolution of cancer. Despite its critical role in cancer, the mechanisms that generate oncogene-induced re
Externí odkaz:
https://doaj.org/article/3465e31efc2e4d63bc650aa1d9a692b2
Autor:
Betheney R. Pennycook, Eva Vesela, Silvia Peripolli, Tanya Singh, Alexis R. Barr, Cosetta Bertoli, Robertus A. M. de Bruin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
DNA replication is tightly regulated during S phase of the cell cycle to ensure timely and accurate genome duplication. Here, the authors reveal that E2F-dependent transcription determines the maximal amount of DNA a cell is able to synthesise per un
Externí odkaz:
https://doaj.org/article/bee6fa4381464a1ea5a0b25db67a1e23
Autor:
Caroline K. Martin, Jerzy Samolej, Annabel T. Olson, Cosetta Bertoli, Matthew S. Wiebe, Robertus A. M. de Bruin, Jason Mercer
Publikováno v:
Viruses, Vol 14, Iss 2, p 431 (2022)
Modulation of the host cell cycle is a common strategy used by viruses to create a pro-replicative environment. To facilitate viral genome replication, vaccinia virus (VACV) has been reported to alter cell cycle regulation and trigger the host cell D
Externí odkaz:
https://doaj.org/article/13452384b490479aa944c0a205c72470
Autor:
Adi Hendler, Edgar M Medina, Anastasiya Kishkevich, Mehtap Abu-Qarn, Steffi Klier, Nicolas E Buchler, Robertus A M de Bruin, Amir Aharoni
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006778 (2017)
Transcriptional regulatory networks play a central role in optimizing cell survival. How DNA binding domains and cis-regulatory DNA binding sequences have co-evolved to allow the expansion of transcriptional networks and how this contributes to cellu
Externí odkaz:
https://doaj.org/article/7913f6c4194c416e9e29f1c2686a086c
Oncogenes, such as c-Myc, enhance growth and proliferative signaling to promote continuous cell cycle divisions, the hallmark of cancer. The inadvertent consequence of this is an increase in cellular stresses. However, whether and how oncogenes can d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98b58c46b8d11beb76ccf3ed873f4b66
https://doi.org/10.1101/2022.02.02.478796
https://doi.org/10.1101/2022.02.02.478796
Autor:
Marium Rana, Alessio Perotti, Lucy M Bisset, James D Smith, Emma Lamden, Zahra Khan, Media K Ismail, Katherine Ellis, Katie A Armstrong, Samantha L Hodder, Cosetta Bertoli, Leticia Meneguello, Robertus A M de Bruin, Joanna R Morris, Isolda Romero-Canelon, James H R Tucker, Nikolas J Hodges
Publikováno v:
Metallomics. 14
Pancreatic ductal adenocarcinoma (PDAC) is a disease that remains refractory to existing treatments including the nucleoside analogue gemcitabine. In the current study we demonstrate that an organometallic nucleoside analogue, the ferronucleoside 1-(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb4f6adb1d75236ba05bfa5883d4608
https://doi.org/10.1093/mtomcs/mfac041
https://doi.org/10.1093/mtomcs/mfac041
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61059 (2013)
G1/S transcriptional regulation in the budding yeast Saccharomyces cerevisiae depends on three main transcriptional components, Swi4, Swi6 and Mbp1. These proteins constitute two transcription factor complexes that regulate over 300 G1/S transcripts,
Externí odkaz:
https://doaj.org/article/904b6e83827246618078d823bf5c4c10
Autor:
Sian Bray, Siân Culley, Anđela Šarić, Gautam Dey, Gabriel Tarrason Risa, Catherine Fan, Delyan R. Mutavchiev, Robertus A. M. de Bruin, Ricardo Henriques, Luca Pellegrini, Anne E. Hafner, Lena Harker-Kirschneck, Mairi L. Kilkenny, Fredrik Hurtig, Buzz Baum, Colin Davis, Dimitra Papatziamou, Ann-Christin Lindås, Ambrosius P. Snijders, Leticia Meneguello, André A. Pulschen, Nicholas P. Robinson, Peter Faull, Diorge P. Souza
Publikováno v:
Science
Proteasomal control of division in Archaea In eukaryotes, proteasome-mediated degradation of cell cycle factors triggers mitotic exit, DNA segregation, and cytokinesis, a process that culminates in abscission dependent on the protein ESCRT-III. By st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d492ef9cf289e7440840d230cd2d2a3
https://doi.org/10.1126/science.aaz2532
https://doi.org/10.1126/science.aaz2532
Autor:
Cosetta Bertoli, Sara Ahrabi, Theresa E. Leon, José Afonso Guerra-Assunção, Sunniyat Rahman, Nadine Farah, Simon Richardson, Marc R. Mansour, Tanya Rapoz-D'Silva, Stephen Henderson, Javier Herrero, Brian Philip, Rajeev Gupta, Michael Magnussen, Robertus A. M. de Bruin, David C. Linch, Elisabeth P. Nacheva
Publikováno v:
Cancer Discov
Loss-of-function mutations of EZH2, the enzymatic component of PRC2, have been associated with poor outcome and chemotherapy resistance in T-cell acute lymphoblastic leukemia (T-ALL). Using isogenic T-ALL cells, with and without CRISPR/Cas9–induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0804c706f8f78b6109961c194ed493
https://europepmc.org/articles/PMC7611258/
https://europepmc.org/articles/PMC7611258/
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17211 (2011)
BACKGROUND:In fission yeast Schizosaccharomyces pombe G1/S cell-cycle regulated transcription depends upon MBF. A negative feedback loop involving Nrm1p and Yox1p bound to MBF leads to transcriptional repression as cells exit G1 phase. However, activ
Externí odkaz:
https://doaj.org/article/e5c6b5ea12224f809e66e4fc21a09b13