In silico model for automated calculation of functional metrics in animal models of peripheral nerve injury repair.

Autor: Laranjeira S; UCL Mechanical Engineering, London, UK; UCL Centre for Nerve Engineering, UK. Electronic address: s.laranjeira@ucl.ac.uk., Guillemot-Legris O; Department of Pharmacology, UCL School of Pharmacy, London, UK; UCL Centre for Nerve Engineering, UK., Girmahun G; Department of Pharmacology, UCL School of Pharmacy, London, UK; UCL Centre for Nerve Engineering, UK., Roberton V; Department of Pharmacology, UCL School of Pharmacy, London, UK; UCL Centre for Nerve Engineering, UK., Phillips JB; Department of Pharmacology, UCL School of Pharmacy, London, UK; UCL Centre for Nerve Engineering, UK., Shipley RJ; UCL Mechanical Engineering, London, UK; UCL Centre for Nerve Engineering, UK.

Publikováno v: Computers in biology and medicine [Comput Biol Med] 2024 Oct; Vol. 181, pp. 109036. Date of Electronic Publication: 2024 Aug 29.

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.

Autor: Gong GQ; Cell Signalling, Cancer Institute, University College London, London, UK., Bilanges B; Cell Signalling, Cancer Institute, University College London, London, UK., Allsop B; Drug Discovery Group, Translational Research Office, University College London, London, UK., Masson GR; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.; Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, UK., Roberton V; UCL Centre for Nerve Engineering, UCL School of Pharmacy, University College London, London, UK., Askwith T; Drug Discovery Group, Translational Research Office, University College London, London, UK., Oxenford S; Drug Discovery Group, Translational Research Office, University College London, London, UK., Madsen RR; Cell Signalling, Cancer Institute, University College London, London, UK., Conduit SE; Cell Signalling, Cancer Institute, University College London, London, UK., Bellini D; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Fitzek M; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Alderley Park, Macclesfield, UK., Collier M; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Alderley Park, Macclesfield, UK., Najam O; The Hatter Cardiovascular Institute, University College London, London, UK., He Z; The Hatter Cardiovascular Institute, University College London, London, UK., Wahab B; Medicines Discovery Institute, School of Biosciences, Cardiff University, Cardiff, UK., McLaughlin SH; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Chan AWE; Wolfson Institute for Biomedical Research, University College London, London, UK., Feierberg I; Molecular AI, Discovery Sciences, R&D, AstraZeneca, Waltham, MA, USA., Madin A; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Morelli D; Cell Signalling, Cancer Institute, University College London, London, UK., Bhamra A; Proteomics Research Translational Technology Platform, Cancer Institute, University College London, London, UK., Vinciauskaite V; Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, UK., Anderson KE; Signalling Programme, Babraham Institute, Cambridge, UK., Surinova S; Proteomics Research Translational Technology Platform, Cancer Institute, University College London, London, UK., Pinotsis N; Institute of Structural and Molecular Biology, Birkbeck College, London, UK., Lopez-Guadamillas E; Cell Signalling, Cancer Institute, University College London, London, UK., Wilcox M; UCL Centre for Nerve Engineering, UCL School of Pharmacy, University College London, London, UK., Hooper A; Drug Discovery Group, Translational Research Office, University College London, London, UK., Patel C; Drug Discovery Group, Translational Research Office, University College London, London, UK., Whitehead MA; Cell Signalling, Cancer Institute, University College London, London, UK., Bunney TD; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK., Stephens LR; Signalling Programme, Babraham Institute, Cambridge, UK., Hawkins PT; Signalling Programme, Babraham Institute, Cambridge, UK., Katan M; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK., Yellon DM; The Hatter Cardiovascular Institute, University College London, London, UK., Davidson SM; The Hatter Cardiovascular Institute, University College London, London, UK., Smith DM; Emerging Innovations, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Phillips JB; UCL Centre for Nerve Engineering, UCL School of Pharmacy, University College London, London, UK., Angell R; Drug Discovery Group, Translational Research Office, University College London, London, UK.; Medicines Discovery Institute, School of Biosciences, Cardiff University, Cardiff, UK., Williams RL; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Vanhaesebroeck B; Cell Signalling, Cancer Institute, University College London, London, UK. bart.vanh@ucl.ac.uk.

Publikováno v: Nature [Nature] 2023 Jun; Vol. 618 (7963), pp. 159-168. Date of Electronic Publication: 2023 May 24.

Engineered aligned endothelial cell structures in tethered collagen hydrogels promote peripheral nerve regeneration.

Autor: Muangsanit P; Department of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, 256 Grays Inn Rd, London WC1X8LD, United Kingdom; UCL Centre for Nerve Engineering, University College London, London, United Kingdom; Department of Pharmacology, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, Bloomsbury, London WC1N 1AX, United Kingdom. Electronic address: papon.muangsanit.14@ucl.ac.uk., Roberton V; UCL Centre for Nerve Engineering, University College London, London, United Kingdom; Department of Pharmacology, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, Bloomsbury, London WC1N 1AX, United Kingdom., Costa E; Department of Pharmacology, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, Bloomsbury, London WC1N 1AX, United Kingdom., Phillips JB; UCL Centre for Nerve Engineering, University College London, London, United Kingdom; Department of Pharmacology, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, Bloomsbury, London WC1N 1AX, United Kingdom.

Publikováno v: Acta biomaterialia [Acta Biomater] 2021 May; Vol. 126, pp. 224-237. Date of Electronic Publication: 2021 Mar 22.

Bioprocessing strategies to enhance the challenging isolation of neuro-regenerative cells from olfactory mucosa.

Autor: Georgiou M; Department of Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.; Cell and Gene Therapy Catapult, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK., Reis JND; Department of Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK., Wood R; Department of Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.; Aston Medical Research Institute and School of Life & Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK., Esteban PP; Department of Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.; Aston Medical Research Institute and School of Life & Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK., Roberton V; Department of Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK., Mason C; Department of Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK., Li D; Spinal Repair Unit, Department of Brain, Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK., Li Y; Spinal Repair Unit, Department of Brain, Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK., Choi D; Spinal Repair Unit, Department of Brain, Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.; National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK., Wall I; Department of Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK. i.wall@aston.ac.uk.; Aston Medical Research Institute and School of Life & Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK. i.wall@aston.ac.uk.; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 31116, Republic of Korea. i.wall@aston.ac.uk.

Publikováno v: Scientific reports [Sci Rep] 2018 Sep 27; Vol. 8 (1), pp. 14440. Date of Electronic Publication: 2018 Sep 27.

Innovations in Peripheral Nerve Regeneration.

Autor: Lam, Ting Chak¹ (AUTHOR) u3507413@connect.hku.hk, Leung, Yiu Yan¹ (AUTHOR) mikeyyleung@hku.hk

Publikováno v: Bioengineering (Basel). May2024, Vol. 11 Issue 5, p444. 14p.