Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Roberto Zoncu"'
Autor:
Aakriti Jain, Roberto Zoncu
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101481- (2022)
Background: Spatial compartmentalization of metabolic pathways within membrane-separated organelles is key to the ability of eukaryotic cells to precisely regulate their biochemical functions. Membrane-bound organelles such as mitochondria, endoplasm
Externí odkaz:
https://doaj.org/article/ec986cf40f6d47e596265b7ba77b79b2
Autor:
Ofer Moldavski, Peter-James H. Zushin, Charles A. Berdan, Robert J. Van Eijkeren, Xuntian Jiang, Mingxing Qian, Daniel S. Ory, Douglas F. Covey, Daniel K. Nomura, Andreas Stahl, Ethan J. Weiss, Roberto Zoncu
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100051- (2021)
Oxysterols are oxidized derivatives of cholesterol that play regulatory roles in lipid biosynthesis and homeostasis. How oxysterol signaling coordinates different lipid classes such as sterols and triglycerides remains incompletely understood. Here,
Externí odkaz:
https://doaj.org/article/486839a449b44a929c2b2c5b68c4be5b
Autor:
Justin A. De Leon, Jiazhang Qiu, Christopher J. Nicolai, Jessica L. Counihan, Kevin C. Barry, Li Xu, Rosalie E. Lawrence, Brian M. Castellano, Roberto Zoncu, Daniel K. Nomura, Zhao-Qing Luo, Russell E. Vance
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2031-2038 (2017)
All pathogens must acquire nutrients from their hosts. The intracellular bacterial pathogen Legionella pneumophila, the etiological agent of Legionnaires’ disease, requires host amino acids for growth within cells. The mechanistic target of rapamyc
Externí odkaz:
https://doaj.org/article/5471c9ca16a2435a881c2dc09deba9c1
Autor:
Vladislav Belyy, Sheng-Min Shih, Jigar Bandaria, Yongjian Huang, Rosalie E. Lawrence, Roberto Zoncu, Ahmet Yildiz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Tracking single molecules in living cells is difficult or impractical owing to their high density. Here the authors introduce a technique of repeatedly photobleaching fluorophores at the boundary of a region of interest, thereby controlling the numbe
Externí odkaz:
https://doaj.org/article/77efbc9571114b969331b9cd398322cf
Autor:
Maria Manifava, Matthew Smith, Sergio Rotondo, Simon Walker, Izabella Niewczas, Roberto Zoncu, Jonathan Clark, Nicholas T Ktistakis
Publikováno v:
eLife, Vol 5 (2016)
Amino acids are essential activators of mTORC1 via a complex containing RAG GTPases, RAGULATOR and the vacuolar ATPase. Sensing of amino acids causes translocation of mTORC1 to lysosomes, an obligate step for activation. To examine the spatial and te
Externí odkaz:
https://doaj.org/article/4dc6536b39b6477aad81350250f078cf
Autor:
Rushika M. Perera, Roberto Zoncu, Terrance G. Johns, Marc Pypaert, Fook-Thean Lee, Ira Mellman, Lloyd J. Old, Derek K. Toomre, Andrew M. Scott
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 12, Pp 1099-1110 (2007)
Overexpression of the epidermal growth factor receptor (EGFR) in epithelial tumors is associated with poor prognosis and is the target for a number of cancer therapeutics. Monoclonal antibody (mAb) 806 is a novel anti-EGFR antibody with significant t
Externí odkaz:
https://doaj.org/article/7037df0cbea3460c9d4810c8ff9b2c64
Autor:
Ravi K. Amaravadi, Jeffrey D. Winkler, David W. Speicher, Donita C. Brady, Roberto Zoncu, Meenhard Herlyn, Xiaowei Xu, Shujing Liu, Qin Liu, Ronen Marmorstein, Joshua Rabinowitz, Yiling Lu, Gordon B. Mills, Maureen E. Murphy, Julie S. Barber-Rotenberg, Zhi Wei, Samuel M. Levi, Rani Ojha, Sengottuvelan Murugan, Shengfu Piao, Gretchen M. Alicea, Gao Zhang, Cynthia I. Chude, Eric Witze, Chun-Yan Lim, Michel Nofal, Amruta Ronghe, Quentin McAfee, Colin Fennelly, Noel McLaughlin, Michael C. Nicastri, Vito W. Rebecca
Supplemental Chemical Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a73a32df39358814d1916585f5a9c6
https://doi.org/10.1158/2159-8290.22532497.v1
https://doi.org/10.1158/2159-8290.22532497.v1
Autor:
Ravi K. Amaravadi, Jeffrey D. Winkler, David W. Speicher, Donita C. Brady, Roberto Zoncu, Meenhard Herlyn, Xiaowei Xu, Shujing Liu, Qin Liu, Ronen Marmorstein, Joshua Rabinowitz, Yiling Lu, Gordon B. Mills, Maureen E. Murphy, Julie S. Barber-Rotenberg, Zhi Wei, Samuel M. Levi, Rani Ojha, Sengottuvelan Murugan, Shengfu Piao, Gretchen M. Alicea, Gao Zhang, Cynthia I. Chude, Eric Witze, Chun-Yan Lim, Michel Nofal, Amruta Ronghe, Quentin McAfee, Colin Fennelly, Noel McLaughlin, Michael C. Nicastri, Vito W. Rebecca
Supplemental Figures and Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757ddfcdc3c0b0e67e8ed83b0beed685
https://doi.org/10.1158/2159-8290.22532494
https://doi.org/10.1158/2159-8290.22532494
Autor:
Claire S. Goul, Roberto Zoncu
Publikováno v:
Developmental cell. 57(20)
Lysosomes, guardians of cell health, can sustain physical damage from biological, mechanical, and chemical stressors, necessitating dedicated mechanisms for their upkeep. In a recent issue of Nature, Tan and Finkel report the discovery of a lysosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6060d18689b6f5bf16be4f069130f3db
https://pubmed.ncbi.nlm.nih.gov/36283389
https://pubmed.ncbi.nlm.nih.gov/36283389
Autor:
Rachel M. Jansen, Roberta Peruzzo, Simon A. Fromm, Adam L. Yokom, Roberto Zoncu, James H. Hurley
Publikováno v:
Science Advances. 8
The mechanistic target of rapamycin complex 1 (mTORC1) regulates cell growth and catabolism in response to nutrients through phosphorylation of key substrates. The tumor suppressor folliculin (FLCN) is a RagC/D guanosine triphosphatase (GTPase)–act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ab8c6db1085b0c00132e914ba3bab8
https://doi.org/10.1126/sciadv.add2926
https://doi.org/10.1126/sciadv.add2926