Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Roberto Tomatis"'
Publikováno v:
Arzneimittelforschung. 50:564-568
A series of HIV-1 protease inhibitors based on the lead compound Pc (IC50 = 165 nmol/l) with structural modifications at P1/P1' substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d421278b70d76219b807ef6b2f64605a
https://doi.org/10.1055/s-0031-1300250
https://doi.org/10.1055/s-0031-1300250
Publikováno v:
Arzneimittelforschung. 50:507-511
A series of secondary and tertiary pyridyl amides as potential central nicotinic acetylcholine receptors (nAChRs) ligands were prepared. Amides displayed negligible or very low affinity, whereas two amines achieved by reduction of corresponding secon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ff6dec2636ad60e50b61cddbd7244c
https://doi.org/10.1055/s-0031-1300238
https://doi.org/10.1055/s-0031-1300238
Autor:
Mauro Marastoni, Federica Destro, Anna Baldisserotto, Roberto Tomatis, Valeria Ferretti, Riccardo Gavioli, Christian Franceschini
Publikováno v:
Journal of Medicinal Chemistry. 53:6511-6515
Because of the encouraging results obtained using vinyl ester derivatives, we synthesized and tested a novel series of peptide-based proteasome inhibitors bearing a new pharmacophore unit at the C-terminal. N-Acylpyrrole moiety is a potential substra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7014e072e5fe49b1a74fa64c0a4eb985
https://doi.org/10.1021/jm100122e
https://doi.org/10.1021/jm100122e
Publikováno v:
International Journal of Peptide and Protein Research. 8:65-77
The general strategy for the synthesis, by conventional procedures, of the entire sequence of porcine pancreatic secretory trypsin inhibitor II (Kazal) is discussed. The synthesis of two protected peptides corresponding to positions 2-10 and 1-10 of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3118e03414932f0e4288c543348a2f88
https://doi.org/10.1111/j.1399-3011.1976.tb02482.x
https://doi.org/10.1111/j.1399-3011.1976.tb02482.x
Autor:
Mauro Marastoni, Severo Salvadori, Giuliano Marzola, Ettore Ciro Degliuberti, Gianfranco Balboni, Roberto Tomatis
Publikováno v:
International Journal of Peptide and Protein Research. 28:274-281
Dermorphinoyl(DMR)-glycine, DMR-sarcosine and DMR-glycyl-arginine have been prepared in order to examine the effect of C-terminal extension of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) on opioid activity. On GPI preparation the addition of Gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc577cd92c95a152c219406c56fa43b
https://doi.org/10.1111/j.1399-3011.1986.tb03256.x
https://doi.org/10.1111/j.1399-3011.1986.tb03256.x
Autor:
V. Scaranari, Eva Reali, Mauro Marastoni, Roberto Tomatis, S. Salvadori, G. Balboni, Serena Traniello, Susanna Spisani
Publikováno v:
Scopus-Elsevier
Using the potent cyclic peptide T analog-Thr-Thr-Asn-Tyr-Thr-Asp- as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5092021566d258b04d5af330c6a0167c
https://doi.org/10.1111/j.1399-3011.1993.tb00464.x
https://doi.org/10.1111/j.1399-3011.1993.tb00464.x
Publikováno v:
International Journal of Peptide and Protein Research. 28:91-100
Dehydropeptide analogs of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) and N-terminal fragments containing one or two dehydrophenylalanine residues in the 3rd and/or 5th position, have been investigated by means of CD spectroscopy. The results in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccbc73d6ffe589b9bd66bd10d359375
https://doi.org/10.1111/j.1399-3011.1986.tb03233.x
https://doi.org/10.1111/j.1399-3011.1986.tb03233.x
Publikováno v:
Scopus-Elsevier
The synthesis, by fragment condensation, of protected peptides related to the N-terminal (positions 1-14) and C-terminal (positions 36-52) portions of the amino acid sequence of porcine pancreatic secretory trypsin inhibitor II (Kazal type) is descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6197427367aaa917875c57b73c2c3aae
https://doi.org/10.1111/j.1399-3011.1977.tb03473.x
https://doi.org/10.1111/j.1399-3011.1977.tb03473.x
Publikováno v:
Scopus-Elsevier
H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 (demorphin), and opiate-like peptide, and tri-, tetra-, penta- and hexapeptide-amide analogs, were synthesized by conventional methods in solution, to determine the minimum peptide chain-length, required for analge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0d4b3340c7942939f15b7a34b327cc
https://doi.org/10.1111/j.1399-3011.1982.tb02639.x
https://doi.org/10.1111/j.1399-3011.1982.tb02639.x
Autor:
Stella Fiorini, Mauro Marastoni, Riccardo Gavioli, Anna Baldisserotto, Roberto Tomatis, Valeria Ferretti, Loretta Pretto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1849-1854
The 20S proteasome is a multicatalytic protease complex responsible for the degradation of many proteins in mammalian cells. Specific inhibition of proteasome enzymatic subunits represents a topic of great interest for the development of new drug the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abcf2e02a4a069a6c9886e9371fe76e
https://doi.org/10.1016/j.bmcl.2008.02.016
https://doi.org/10.1016/j.bmcl.2008.02.016