Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Roberto Tolando"'
Autor:
Tara Williamson, Jens Lamerz, Peter Jakob, Thierry Lavé, Paul Cutler, Roberto Tolando, Stephen Fowler, Arno Friedlein, Aki T. Heikkinen, Neil Parrott
Publikováno v:
Pharmaceutical Research. 29:1832-1842
Physiologically based models, when verified in pre-clinical species, optimally predict human pharmacokinetics. However, modeling of intestinal metabolism has been a gap. To establish in vitro/in vivo scaling factors for metabolism, the expression and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9edd14ded457f0693713c48223b7e9
https://doi.org/10.1007/s11095-012-0707-7
https://doi.org/10.1007/s11095-012-0707-7
Autor:
Jim Iley, Roberto Tolando
Publikováno v:
Scopus-Elsevier
N-(But-3-enyl)-N-methylbenzamide 14a undergoes microsomal oxidation by rat liver microsomes to yield both N-methyl- and N-(but-3-enyl)benzamides 18a and 19, the products of N-dealkylation. Cyclic products, that could be derived from a carbon-centred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1858301b5441963d0b6a3762ec1e2268
https://doi.org/10.1039/b001756f
https://doi.org/10.1039/b001756f
Publikováno v:
Toxicology and Applied Pharmacology. 143:420-428
The reductive metabolic activation of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123), one of the potential substitutes for the ozone-depleting chlorofluorocarbons and a close structural analogue of the hepatotoxic anesthetic halothane, was investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5aae78811f06b2efc3ca99afbc2bbc
https://doi.org/10.1006/taap.1996.8064
https://doi.org/10.1006/taap.1996.8064
Publikováno v:
Toxicology. 100:175-183
Human haemoglobin (Hb), methaemalbumin (MHA) or rat liver microsomal cytochrome P-450 (P-450) were incubated anaerobically at μM concentrations with 1 mM carbon tetrachloride (CCl4), trichlorobromomethane (CCl3Br), chloroform (CHCl3) or methylene ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9936f37c9b65925b10b7483988b1209c
https://doi.org/10.1016/0300-483x(95)03083-r
https://doi.org/10.1016/0300-483x(95)03083-r
Publikováno v:
Alternatives to Laboratory Animals. 21:57-64
The reductive metabolism of carbon tetrachloride (CC14) by human haemoglobin (Hb) was observed in vitro by absolute absorption spectra recorded under anaerobic conditions. The following results were obtained: 1) a decrease of the 430nm peak typical o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d8f85baba0f69593143d92c70447fc
https://doi.org/10.1177/026119299302100110
https://doi.org/10.1177/026119299302100110
Publikováno v:
ChemInform. 32
The conformationally restricted tertiary amides N-methyl-2-pyrrolidone 6, N-methyl-2-piperidone 7 and N-methyl-e-caprolactam 8 were oxidised by 5,10,15,20-tetraphenylporphyrinatoiron(III) chloride/tert-butyl hydroperoxide (TPPFe/ButOOH) and by phenob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab10d06740836d4ae7910def47af5b55
https://doi.org/10.1002/chin.200145029
https://doi.org/10.1002/chin.200145029
Autor:
P. Giovanni Gervasi, Roberto Tolando, Francesco Rossignolo, Vincenzo Longo, Annalisa Nannelli, Paolo Rossato
Publikováno v:
Toxicology. 265(3)
The constitutive and inducible expression of aryl hydrocarbon receptor (AhR) and of the AhR-regulated genes coding for CYP1A1, CYP1A2, CYP1B1, CYP2S1, and Nrf2 was investigated by real-time or traditional PCR in cerebral areas (cortex, cerebellum, mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817ce8b2e436ee2ca954edc283c00b98
https://pubmed.ncbi.nlm.nih.gov/19786062
https://pubmed.ncbi.nlm.nih.gov/19786062
Autor:
Vincenzo Longo, Roberto Tolando, Francesco Rossignolo, Annalisa Nannelli, Paolo Rossato, Mario Pellegatti, P. Giovanni Gervasi
Publikováno v:
Molecular and cellular biochemistry 337 (2010): 133–143. doi:10.1007/s11010-009-0292-1
info:cnr-pdr/source/autori:Nannelli A., Rossignolo F., Tolando R., Rossato P., Pellegatti M., Longo V., Gervasi P. G./titolo:Expression and distribution of CYP3A genes, CYP2B22, and MDR1, MRP1, MRP2, LRP efflux transporters in brain of control and rifampicin-treated pigs/doi:10.1007%2Fs11010-009-0292-1/rivista:Molecular and cellular biochemistry/anno:2010/pagina_da:133/pagina_a:143/intervallo_pagine:133–143/volume:337
info:cnr-pdr/source/autori:Nannelli A., Rossignolo F., Tolando R., Rossato P., Pellegatti M., Longo V., Gervasi P. G./titolo:Expression and distribution of CYP3A genes, CYP2B22, and MDR1, MRP1, MRP2, LRP efflux transporters in brain of control and rifampicin-treated pigs/doi:10.1007%2Fs11010-009-0292-1/rivista:Molecular and cellular biochemistry/anno:2010/pagina_da:133/pagina_a:143/intervallo_pagine:133–143/volume:337
The in vivo effect of rifampicin, a potent ligand of PXR, on gene expression of CYP2B22, 3A22, 3A29, 3A46, CAR, PXR and MDR1, MRP1, MRP2, LRP transporters in liver and cortex, cerebellum, midbrain, hippocampus, meninges and brain capillaries of pig w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48757783f8e66725505d49fdf00ec667
https://pubmed.ncbi.nlm.nih.gov/19844775
https://pubmed.ncbi.nlm.nih.gov/19844775
Publikováno v:
Toxicology letters. 124(1-3)
N,N-dimethylformamide (DMF), an organic solvent widely used in industry, is bioactivated by cytochrome P450 (P450) to reactive metabolites which are believed to be responsible for the hepatotoxicity observed in animals and humans. A decrease of the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a957abbca52857f0f29ccabe4d2380
https://pubmed.ncbi.nlm.nih.gov/11684362
https://pubmed.ncbi.nlm.nih.gov/11684362
Autor:
Jim Iley, Roberto Tolando
Publikováno v:
ChemInform. 32
N-(But-3-enyl)-N-methylbenzamide 14a undergoes microsomal oxidation by rat liver microsomes to yield both N-methyl- and N-(but-3-enyl)benzamides 18a and 19, the products of N-dealkylation. Cyclic products, that could be derived from a carbon-centred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf86bc664cffcf4188c376aa69d19452
https://doi.org/10.1002/chin.200111035
https://doi.org/10.1002/chin.200111035