The Urine Metabolome of R6/2 and zQ175DN Huntington’s Disease Mouse Models

Autor: Roberto Speziale, Camilla Montesano, Giulia Di Pietro, Daniel Oscar Cicero, Vincenzo Summa, Edith Monteagudo, Laura Orsatti

Publikováno v: Metabolites, Vol 13, Iss 8, p 961 (2023)

Huntington’s disease (HD) is caused by the expansion of a polyglutamine (polyQ)-encoding tract in exon 1 of the huntingtin gene to greater than 35 CAG repeats. It typically has a disease course lasting 15–20 years, and there are currently no dise

Externí odkaz: https://doaj.org/article/7a92756f06cd4e50be6195e730b03141

Personalized Metabolic Profile by Synergic Use of NMR and HRMS

Autor: Greta Petrella, Camilla Montesano, Sara Lentini, Giorgia Ciufolini, Domitilla Vanni, Roberto Speziale, Andrea Salonia, Francesco Montorsi, Vincenzo Summa, Riccardo Vago, Laura Orsatti, Edith Monteagudo, Daniel Oscar Cicero

Publikováno v: Molecules, Vol 26, Iss 14, p 4167 (2021)

A new strategy that takes advantage of the synergism between NMR and UHPLC–HRMS yields accurate concentrations of a high number of compounds in biofluids to delineate a personalized metabolic profile (SYNHMET). Metabolite identification and quantif

Externí odkaz: https://doaj.org/article/909a2745bb8f4e96a349ad3eb10de1c9

Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease

Autor: Carsten Müller-Tidow, Thomas Luft, Roberto Speziale, Thomas Stiehl, Laura Orsatti, Aleksandar Radujkovic, Katharina Dischinger, Peter Dreger, Edith Monteagudo, Pamela Di Pasquale

Publikováno v: Cell reports 2(10), 100409 (2021). doi:10.1016/j.xcrm.2021.100409
Cell Reports Medicine
Cell Reports Medicine, Vol 2, Iss 10, Pp 100409-(2021)

Summary Fibrosing chronic graft-versus-host disease (cGVHD) is a debilitating complication of allogeneic stem cell transplantation (alloSCT). A driver of fibrosis is the kynurenine (Kyn) pathway, and Kyn metabolism patterns and cytokines may influenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495108ade46a9cf16537e41d8e6b30ad
https://publications.rwth-aachen.de/record/846567

Kynurenine Pathway Activation and Deviation in Fibrosing Chronic Graft-Versus-Host Disease

Autor: Pamela Di Pasquale, Roberto Speziale, Orsatti Laura, Aleksandar Radujkovic, Carsten Mueller-Tidow, Thomas Stiehl, Katharina Dischinger, Edith Monteagudo, Thomas Luft, Peter Dreger

Publikováno v: Blood. 138:3895-3895

Background: Fibrosing chronic graft-versus-host disease (cGVHD) is a debilitating complication after allogeneic stem cell transplantation (allo-SCT), and its pathophysiology is poorly understood. Kynurenine and its metabolites were shown to associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f546f6bdeb10bcca70339631f3a30317
https://doi.org/10.1182/blood-2021-152793

Extraction and analysis of fungal spore biomarkers in atmospheric bioaerosol by HPLC–MS–MS and GC–MS

Autor: Carmela Riccardi, Donatella Pomata, Francesca Buiarelli, Patrizia Di Filippo, Silvia Canepari, Cinzia Perrino, Roberto Speziale

Publikováno v: Talanta. 105:142-151

Airborne microorganisms, as bacteria and fungi, are ubiquitous components of the atmospheric aerosol particles. In this paper, we report a method for the simultaneous extraction, purification, separation, identification and quantification of ergoster

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77999588e097819f33256c19cf20ad49
https://doi.org/10.1016/j.talanta.2012.11.006