A short PNA targeting coxsackievirus B3 5′-nontranslated region prevents virus-induced cytolysis

Autor: Matthias Görlach, Domenica Capasso, Margherita Valente, Roland Zell, Carlo Pedone, Enrico M. Bucci, Domenica Musumeci, Giovanni N. Roviello, Roberto Sapio, Rosanna Palumbo, Michaela Schmidtke

Publikováno v: Journal of peptide science
12 (2006): 161–170. doi:10.1002/psc.708
info:cnr-pdr/source/autori:Musumeci, D.; Valente, M.; Capasso, D.; Palumbo, R.; Görlach, M.; Schmidtke, M.; Zell, R.; Roviello, G.N.; Sapio, R.; Pedone, C.; Bucci, E.M./titolo:A short PNA targeting coxsackievirus B3 5-nontranslated region prevents virus-induced cytolysis/doi:10.1002%2Fpsc.708/rivista:Journal of peptide science (Print)/anno:2006/pagina_da:161/pagina_a:170/intervallo_pagine:161–170/volume:12
info:cnr-pdr/source/autori:Musumeci, Domenica; Valente, Margherita; Capasso, Domenica; Palumbo, Rosanna; Gorlach, Matthias; Schmidtke, Michaela; Zell, Roland; Roviello, Giovanni N.; Sapio, Roberto; Pedone, Carlo; Bucci, Enrico M./titolo:A short PNA targeting coxsackievirus B3 5'-nontranslated region prevents virus-induced cytolysis./doi:10.1002%2Fpsc.708/rivista:Journal of peptide science (Print)/anno:2006/pagina_da:161/pagina_a:170/intervallo_pagine:161–170/volume:12

Targeting regulatory RNA regions to interfere with the biosynthesis of a protein is an intriguing alternative to targeting a protein itself. Regulatory regions are often unique in sequence and/or structure and, thus, ideally suited for specific recog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac9f325ccd7bf7f3dfdb5891d74fbbc
https://doi.org/10.1002/psc.708

ODN-Based Drugs for Targeting of Extracellular Proteins

Autor: Maria Moccia, Roberto Sapio, Enrico M. Bucci, Margherita Valente, V Anrò, Giovanni N. Roviello, Domenica Musumeci

Publikováno v: Nucleosides, Nucleotides & Nucleic Acids. 26:1047-1050

In this work a novel approach to identify new therapeutic targets consisting of serum proteins which contain an oligonucleotide binding domain is presented.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4092a16ddd2b88654ad4c0c2998dc5be
https://doi.org/10.1080/15257770701509602

DNA-based strategies for blocking HMGB1 cytokine activity: design,synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes

Autor: Margherita Valente, Maria Moccia, Giovanni N. Roviello, Roberto Sapio, Carlo Pedone, Domenica Musumeci, Enrico M. Bucci, Marco Bianchi

Publikováno v: Molecular bioSystems (Online) 7 (2011): 1742–1752. doi:10.1039/c1mb05009e
info:cnr-pdr/source/autori:Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME,Pedone C/titolo:DNA-based strategies for blocking HMGB1 cytokine activity: design,synthesis and preliminary in vitro%2Fin vivo assays of DNA and DNA-like duplexes/doi:10.1039%2Fc1mb05009e/rivista:Molecular bioSystems (Online)/anno:2011/pagina_da:1742/pagina_a:1752/intervallo_pagine:1742–1752/volume:7

In this work we report the design and synthesis of kinked oligonucleotide duplexes as potential inhibitors of HMGB1, a cytokine which triggers a broad range of immunological effects. We found that the designed ligands can interact with HMGB1, as evid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7294c8b7a071eab33dc3c06d0827dce1
http://www.cnr.it/prodotto/i/212377

dabPNA: design, synthesis, and DNA binding studies

Autor: Giovanni N. Roviello, Giuseppe Perretta, Margherita Valente, Enrico M. Bucci, Maria Moccia, Carlo Pedone, Domenica Musumeci, Roberto Sapio, M Castiglione

In continuing our research efforts for developing new oligodeoxynucleotide (ODN)-like drugs and diagnostics, we designed diaminobutyric peptide nucleic acids (dabPNAs), nucleopeptides characterized by a diaminobutyric-based building block that is an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec916693f21398a5ccc021d352deee24
http://hdl.handle.net/11588/205421

New synthesis of PNA-3 ' DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras

Autor: Giovanni N. Roviello, Enrico M. Bucci, Roberto Sapio, Carlo Pedone, Margherita Valente, Domenica Musumeci

Publikováno v: Biopolymers
76 (2004): 535–542. doi:10.1002/bip.20135
info:cnr-pdr/source/autori:Musumeci, D.; Roviello, G.N.; Valente, M.; Sapio, R.; Pedone, C.; Bucci, E.M./titolo:New synthesis of PNA-3 ' DNA linker monomers, useful building blocks to obtain PNA%2FDNA chimeras/doi:10.1002%2Fbip.20135/rivista:Biopolymers (Print)/anno:2004/pagina_da:535/pagina_a:542/intervallo_pagine:535–542/volume:76
info:cnr-pdr/source/autori:Domenica Musumeci; Giovanni N Roviello; Margherita Valente; Roberto Sapio; Carlo Pedone; Enrico M Bucci/titolo:New synthesis of PNA-3? DNA linker monomers, useful building blocks to obtain PNA%2FDNA chimeras/doi:10.1002%2Fbip.20135/rivista:Biopolymers (Print)/anno:2004/pagina_da:535/pagina_a:542/intervallo_pagine:535–542/volume:76

A new synthetic strategy to get the PNA-3? DNA linker with the monomethoxytrityl (Mmt) group as temporary protection of the backbone to be used for the synthesis of PNA/DNA chimeras was employed and a convenient strategy to obtain Mmt PNA monomers wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fdb5e3ec5cf88d782aca51c1a6c9cb