Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Roberto N De Guzman"'
Autor:
Junya Kato, Supratim Dey, Jose E Soto, Carmen Butan, Mason C Wilkinson, Roberto N De Guzman, Jorge E Galan
Publikováno v:
eLife, Vol 7 (2018)
Type III protein secretion systems (T3SS) are encoded by several pathogenic or symbiotic bacteria. The central component of this nanomachine is the needle complex. Here we show in a Salmonella Typhimurium T3SS that assembly of the needle filament of
Externí odkaz:
https://doaj.org/article/0b4e2ae158644ceb800dce215a709b3c
Autor:
Kawaljit Kaur, Xiaoqing Wu, James K Fields, David K Johnson, Lan Lan, Miranda Pratt, Amber D Somoza, Clay C C Wang, John Karanicolas, Berl R Oakley, Liang Xu, Roberto N De Guzman
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175471 (2017)
The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3'-untranslated region (UTR) of target mRNAs. The HuR-ARE interactions stabilize many oncogenic mRNAs that play important roles in tumorigenesis. Thus, small molecules
Externí odkaz:
https://doaj.org/article/24cfec8821904a04985a5c129a085c71
Autor:
Roberto N. De Guzman, Hao Liu, Jeffrey Aubé, Lan Lan, Ragul Gowthaman, Rebecca T. Marquez, Sarah Larsen, Liang Xu, Philip Gao, Steven A. Rogers, Jia Yu, Kristi L. Neufeld, Amber R. Smith, Xiaoqing Wu, John Karanicolas, Carl Appelman, Frank Y. Liu
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
BMC Cancer
BMC Cancer
Background The Musashi (MSI) family of RNA-binding proteins is best known for the role in post-transcriptional regulation of target mRNAs. Elevated MSI1 levels in a variety of human cancer are associated with up-regulation of Notch/Wnt signaling. MSI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc119af47e2ee091f36cbb450198528
http://link.springer.com/article/10.1186/s12885-018-4704-z
http://link.springer.com/article/10.1186/s12885-018-4704-z
Publikováno v:
Protein Sci
Many Gram-negative bacteria pathogenic to plants and animals deploy the type III secretion system (T3SS) to inject virulence factors into their hosts. All bacteria that rely on the T3SS to cause infectious diseases in humans have developed antibiotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2077edbf42bd63a0ba2e41fa58aeac9e
https://europepmc.org/articles/PMC6699086/
https://europepmc.org/articles/PMC6699086/
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d94951cd02905229c2a7a0700b79449
https://doi.org/10.1096/fasebj.2019.33.1_supplement.779.47
https://doi.org/10.1096/fasebj.2019.33.1_supplement.779.47
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:1097-1107
The type III secretion system (T3SS) is essential for the pathogenesis of many bacteria including Salmonella and Shigella, which together are responsible for millions of deaths worldwide each year. The structural component of the T3SS consists of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad2b738748555fbf6d3d5d790222c3c7
https://doi.org/10.1002/prot.25055
https://doi.org/10.1002/prot.25055
Publikováno v:
ChemBioChem. 17:745-752
Many Gram-negative pathogens, such as Shigella and Salmonella, assemble the type III secretion system (T3SS) to inject virulence proteins directly into eukaryotic cells to initiate infectious diseases. The needle apparatus of the T3SS consists of a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edd3e3fa7a8ca5e2efcc4f0b95410ad
https://doi.org/10.1002/cbic.201500556
https://doi.org/10.1002/cbic.201500556
Autor:
Carmen Butan, Supratim Dey, Jorge E. Galán, Junya Kato, Jose E Soto, Roberto N. De Guzman, Mason C Wilkinson
Publikováno v:
eLife, Vol 7 (2018)
Type III protein secretion systems (T3SS) are encoded by several pathogenic or symbiotic bacteria. The central component of this nanomachine is the needle complex. Here we show in a Salmonella Typhimurium T3SS that assembly of the needle filament of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca01ea534fc4115a52b28184c380e356
https://doi.org/10.7554/elife.35886
https://doi.org/10.7554/elife.35886
Small ubiquitin-like modifier (SUMO) conjugation is a reversible post-translational modification process implicated in the regulation of gene transcription, DNA repair, and cell cycle. SUMOylation depends on the sequential activities of E1 activating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3e7e5a5fed649fa6f5dd1c4b855098
https://europepmc.org/articles/PMC5473226/
https://europepmc.org/articles/PMC5473226/