Adenosine monophosphate‐activated protein kinase is elevated in human cachectic muscle and prevents cancer‐induced metabolic dysfunction in mice

Autor: Steffen H. Raun, Mona S. Ali, Xiuqing Han, Carlos Henríquez‐Olguín, T.C. Phung Pham, Roberto Meneses‐Valdés, Jonas R. Knudsen, Anna C.H. Willemsen, Steen Larsen, Thomas E. Jensen, Ramon Langen, Lykke Sylow

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 4, Pp 1631-1647 (2023)

Abstract Background Metabolic dysfunction and cachexia are associated with poor cancer prognosis. With no pharmacological treatments, it is crucial to define the molecular mechanisms causing cancer‐induced metabolic dysfunction and cachexia. Adenos

Externí odkaz: https://doaj.org/article/7e761cbfe9a2416998776cb54140a53c

Effects of Polarized Training on Cardiometabolic Risk Factors in Young Overweight and Obese Women: A Randomized-Controlled Trial

Autor: Rafael Zapata-Lamana, Carlos Henríquez-Olguín, Carlos Burgos, Roberto Meneses-Valdés, Igor Cigarroa, Claudio Soto, Valentín E. Fernández-Elías, Sonia García-Merino, Rodrigo Ramirez-Campillo, Antonio García-Hermoso, Hugo Cerda-Kohler

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

Introduction: Volume and intensity are major variables governing exercise training-mediated beneficial effects in both athletes and patients. Although polarized endurance training optimizes and maximizes physiological gains in highly trained individu

Externí odkaz: https://doaj.org/article/3b8846dbdec44293b412d3e127c0db9d

High extracellular ATP levels released through pannexin-1 channels mediate inflammation and insulin resistance in skeletal muscle fibres of diet-induced obese mice

Autor: Roberto Meneses-Valdés, Gonzalo Jorquera, Giovanni Rosales-Soto, Gonzalo Cruz, Paola Llanos, Mónica Silva-Monasterio, Denisse Valladares-Ide, Mariana Casas, Cristian Campos, Enrique Jaimovich

Publikováno v: Diabetologia. 64:1389-1401

Skeletal muscle is a key target organ for insulin’s actions and is the main regulator of blood glucose. In obese individuals and animal models, there is a chronic low-grade inflammatory state affecting highly metabolic organs, leading to insulin re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19c81729fb81d34168be65aac9ae8c74
https://doi.org/10.1007/s00125-021-05418-2

Activation of the NLRP3 Inflammasome Increases the IL-1β Level and Decreases GLUT4 Translocation in Skeletal Muscle during Insulin Resistance

Autor: Paola Llanos, Gonzalo Jorquera, Pablo Sanchez-Aguilera, Javier Russell, Luan Américo-Da-Silva, Manuel Estrada, Oscar Quinteros-Waltemath, Javiera Aguilera, Roberto Meneses-Valdés, Genaro Barrientos, Gina L. Sánchez, Cynthia Cadagan

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10212, p 10212 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 19

Low-grade chronic inflammation plays a pivotal role in the pathogenesis of insulin resistance (IR), and skeletal muscle has a central role in this condition. NLRP3 inflammasome activation pathways promote low-grade chronic inflammation in several tis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4c523cd02b9229a5505dbe6f3f48c7
https://www.mdpi.com/1422-0067/22/19/10212

Exploring the role of compartmentalized H2O2 redox signaling in skeletal muscle stress-adaptations

Autor: Carlos Henriquez, Roberto Meneses-Valdés, Samantha Gallero, Steffen Raun, Tang Cam Phung Pham, Jens Halling, Stine Ringholm, Lykke Sylow, Vsevolod Belousov, Andreas Fritzen, Tina Jeppesen, Kim Rewitz, Henriette Pilegaard, Thomas Jensen

Publikováno v: Free Radical Biology and Medicine. 180:s92

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa5f3c3ff9192e21f498b966ab996898
https://doi.org/10.1016/j.freeradbiomed.2021.12.214