Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Roberto Megias Perez"'
Autor:
Kristina Xiao Liang, Cecilie Katrin Kristiansen, Sepideh Mostafavi, Guro Helén Vatne, Gina Alien Zantingh, Atefeh Kianian, Charalampos Tzoulis, Lena Elise Høyland, Mathias Ziegler, Roberto Megias Perez, Jessica Furriol, Zhuoyuan Zhang, Novin Balafkan, Yu Hong, Richard Siller, Gareth John Sullivan, Laurence A Bindoff
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp n/a-n/a (2020)
Abstract Mutations in POLG disrupt mtDNA replication and cause devastating diseases often with neurological phenotypes. Defining disease mechanisms has been hampered by limited access to human tissues, particularly neurons. Using patient cells carryi
Externí odkaz:
https://doaj.org/article/dfb26524884144999cd67cac00ad6106
Autor:
Mathias Ziegler, Barbara van den Hoeven, Jörn Dietze, Mikhail V. Makarov, Roberto Megias Perez, Roland Sauter, Lars Jansen Sverkeli, Karl Johan Tronstad, Ines Heiland, Marie E. Migaud, Christian Dölle, Lena Elise Høyland, Magali R. VanLinden, Ina Katrine Nitschke Pettersen, Øyvind Strømland, Marc Niere, Camila Cimadamore-Werthein, Ingvill Tolås, Cedric Davidsen, Svein Mjøs
The coenzyme NAD is consumed by signaling enzymes including poly-ADP-ribose-polymerases (PARPs) and sirtuins. Understanding the mechanisms of aging-associated NAD decline and how cells cope with decreased NAD concentrations requires model systems ref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff43d9053c8d23e7a6b34e53ee07627c
https://doi.org/10.21203/rs.3.rs-116850/v1
https://doi.org/10.21203/rs.3.rs-116850/v1
Autor:
Lena Elise Høyland, Gareth J. Sullivan, Roberto Megias Perez, Gina Alien Zantingh, Kristina Xiao Liang, Guro Helén Vatne, Mathias Ziegler, Sepideh Mostafavi, Richard Siller, Laurence A. Bindoff, Novin Balafkan, Atefeh Kianian, Cecilie Katrin Kristiansen, Zhuoyuan Zhang, Jessica Furriol, Yu Hong, Charalampos Tzoulis
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp n/a-n/a (2020)
e12146
EMBO Molecular Medicine
e12146
EMBO Molecular Medicine
Mutations in POLG disrupt mtDNA replication and cause devastating diseases often with neurological phenotypes. Defining disease mechanisms has been hampered by limited access to human tissues, particularly neurons. Using patient cells carrying POLG m
Autor:
Hrvoje Miletic, Jan Haavik, Petri Kursula, Elaheh Mahootchi, Christian Totland, Roberto Megias-Perez, Rune Kleppe, Selina Cannon Himaei, Jeffrey C. Glennon, Floriana Mogavero, Ingeborg Winge, Tor-Arne Hegvik, Anne Baumann
Publikováno v:
eabb3713
6:eabb3713
Science Advances
Science Advances, 6, 29
Science Advances, 6
6:eabb3713
Science Advances
Science Advances, 6, 29
Science Advances, 6
Mice lacking the enzyme GADL1 have reduced levels of carnosine and anserine peptides and increased oxidative stress markers.
Carnosine and related β-alanine–containing peptides are believed to be important antioxidants, pH buffers, and neurom
Carnosine and related β-alanine–containing peptides are believed to be important antioxidants, pH buffers, and neurom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34495a852ab46fae6a37663d04842020
https://hdl.handle.net/11250/2736451
https://hdl.handle.net/11250/2736451