Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Roberto M. Risi"'
Autor:
David L. McElligott, Albert Lai, Alexandre Nesterov, Robert A. Mantei, T. Matthew Hansen, Peter de Vries, Arthur F. Kluge, Ronen Marmorstein, Michael R. Michaelides, Hong Liu, Kesicki Edward A, Kannan R. Karukurichi, J. William Langston, John H. Van Drie, Loren M. Lasko, Carmen Hertel, Michael A. Patane, Kenneth D. Bromberg, Ce Wang, Philip A. Cole, Roberto M. Risi
Publikováno v:
ACS Medicinal Chemistry Letters
p300 and its paralog CBP can acetylate histones and other proteins and have been implicated in a number of diseases characterized by aberrant gene activation, such as cancer. A novel, highly selective, orally bioavailable histone acetyltransferase (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea72017a0bf311573c69bf7322aa291f
https://doi.org/10.1021/acsmedchemlett.7b00395
https://doi.org/10.1021/acsmedchemlett.7b00395
Autor:
Loren M. Lasko, Clarissa G. Jakob, Rohinton P. Edalji, Wei Qiu, Debra Montgomery, Enrico L. Digiammarino, T. Matt Hansen, Roberto M. Risi, Robin Frey, Vlasios Manaves, Bailin Shaw, Mikkel Algire, Paul Hessler, Lloyd T. Lam, Tamar Uziel, Emily Faivre, Debra Ferguson, Fritz G. Buchanan, Ruth L. Martin, Maricel Torrent, Gary G. Chiang, Kannan Karukurichi, J. William Langston, Brian T. Weinert, Chunaram Choudhary, Peter de Vries, Arthur F. Kluge, Michael A. Patane, John H. Van Drie, Ce Wang, David McElligott, Ed Kesicki, Ronen Marmorstein, Chaohong Sun, Philip A. Cole, Saul H. Rosenberg, Michael R. Michaelides, Albert Lai, Kenneth D. Bromberg
Publikováno v:
Nature. 550:128-132
The dynamic and reversible acetylation of proteins, catalysed by histone acetyltransferases (HATs) and histone deacetylases (HDACs), is a major epigenetic regulatory mechanism of gene transcription and is associated with multiple diseases. Histone de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcdc4d0d1efd86b44451095a833f08b
https://doi.org/10.1038/nature24028
https://doi.org/10.1038/nature24028
Publikováno v:
The Journal of Organic Chemistry. 80:204-216
Four different Rh-catalyzed asymmetric hydroformylation (AHF) tandem reactions have been developed in the context of the total syntheses of (+)-patulolide C, (-)-pyrenophorol, (+)-decarestrictine L, and (+)-Prelog-Djerassi lactone. A total synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8245544fdfc45761a80b4c826dc2a7
https://doi.org/10.1021/jo502301k
https://doi.org/10.1021/jo502301k
Autor:
Ruth L. Martin, Peter de Vries, Rohinton Edalji, T. Matt Hansen, Mikkel Algire, Fritz G. Buchanan, Wei Qiu, Brian T. Weinert, John H. Van Drie, Debra Ferguson, Kesicki Edward A, Ronen Marmorstein, Enrico L. Digiammarino, Philip A. Cole, Lloyd T. Lam, Chunaram Choudhary, Robin R. Frey, Loren M. Lasko, Roberto M. Risi, Kannan R. Karukurichi, Michael A. Patane, Debra Montgomery, Kenneth D. Bromberg, Bailin Shaw, Michael R. Michaelides, David L. McElligott, Arthur F. Kluge, J. William Langston, Ce Wang, Chaohong Sun, Vlasios Manaves, Emily J. Faivre, Maricel Torrent, Gary G. Chiang, Paul Hessler, Albert Lai, Saul H. Rosenberg, Clarissa G. Jakob, Tamar Uziel
Publikováno v:
Nature. 558:E1-E1
The dynamic and reversible acetylation of proteins catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs) is a major epigenetic regulatory mechanism of gene transcription 1 associated with multiple diseases. While HDAC inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d97c1de2ea9ff83c19ebbdea520398
https://doi.org/10.1038/s41586-018-0111-5
https://doi.org/10.1038/s41586-018-0111-5
Autor:
Roberto M. Risi, Todd M. Hansen, Clarissa G. Jakob, Mikkel Algire, Tamar Uziel, Lloyd T. Lam, Kenneth D. Bromberg, Vlasios Manaves, Loren M. Lasko, Robin R. Frey, Maricel Torrent, Saul H. Rosenberg, Ruth L. Martin, Debra Montgomery, Bailin Shaw, Michael R. Michaelides, Enrico L. Digiammarino, Wei Qiu, Albert Lai, Paul Hessler, Emily Favire, Fritz G. Buchanan, Debra Ferguson
Publikováno v:
Molecular Cancer Therapeutics. 17:LB-A23
The dynamic and reversible acetylation of proteins catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs) is a major epigenetic regulatory mechanism of gene transcription associated with multiple diseases. While HDAC inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16f9918b04e2fa27f6f2e3b6b4a3f001
https://doi.org/10.1158/1535-7163.targ-17-lb-a23
https://doi.org/10.1158/1535-7163.targ-17-lb-a23
Autor:
Roberto M. Risi, Steven D. Burke
Publikováno v:
Organic Letters. 14:1180-1182
A highly atom-economical total synthesis of (+)-patulolide C has been accomplished in three steps from the known (2R)-8-nonyn-2-ol in 49% overall yield and 93% de. A Rh(I)-catalyzed asymmetric hydroformylation (AHF)/ intramolecular Wittig olefination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b58736e698c0aecaf2550227988b20
https://doi.org/10.1021/ol2034299
https://doi.org/10.1021/ol2034299
Autor:
Roberto M. Risi, Steven D. Burke
Publikováno v:
Organic letters. 14(10)
A synthesis of the Prelog–Djerassi lactone [(+)-1] has been accomplished in three isolations and 57% overall yield from the known vinyl ortho ester 2. A Rh(I)-catalyzed asymmetric hydroformylation/crotylation tandem sequence has been developed and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fe69c1a8fbe200377b760730eb9260
https://pubmed.ncbi.nlm.nih.gov/22559226
https://pubmed.ncbi.nlm.nih.gov/22559226