Výsledky vyhledávání - "Roberto Lara-Lemus"

On The Role of Myelin and Lymphocyte Protein (MAL) In Cancer: A Puzzle With Two Faces

Autor: Roberto Lara-Lemus

Publikováno v: Journal of Cancer

Myelin and lymphocyte protein (MAL) is an integral membrane protein constituent of lipid rafts, and it is implicated in apical transport of proteins in polarized epithelial cells. However, beyond the involvement of MAL in apical sorting and as its fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7015103ed1db2102c29f50d5d12447
http://europepmc.org/articles/PMC6584422

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Ouabain Accelerates Collective Cell Migration Through a cSrc and ERK1/2 Sensitive Metalloproteinase Activity

Autor: Roberto Lara-Lemus, Isabel Larre, Marcelino Cereijido, E. Perez Salazar, O. Verdejo-Torres, Catalina Flores-Maldonado, J. P. Campos-Blázquez, Teresita Padilla-Benavides, Rubén G. Contreras

Publikováno v: The Journal of Membrane Biology. 252:549-559

Studies made in the Madin-Darby canine kidney (MDCK) epithelial cell line showed that ouabain regulates cell adhesion and cell-adhesion-related biological processes, such as migration. Here, we demonstrated that 10 nM ouabain accelerates collective c

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https://doi.org/10.1007/s00232-019-00066-5

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Inefficient Translocation of Preproinsulin Contributes to Pancreatic β Cell Failure and Late-onset Diabetes

Autor: Kathryn Hutchison, Roberto Lara-Lemus, Shu-ou Shan, Ming Liu, Jinhong Sun, Piotr Witkowski, Jingqing Cui, Yi Xiong, Huan Guo, Peter Arvan, Ling Jia Wang, Leena Haataja

Publikováno v: Journal of Biological Chemistry. 289:16290-16302

Among the defects in the early events of insulin biosynthesis, proinsulin misfolding and endoplasmic reticulum (ER) stress have drawn increasing attention as causes of β cell failure. However, no studies have yet addressed potential defects at the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6757d4b918006e7fa21702ca54981dec
https://doi.org/10.1074/jbc.m114.562355

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Effect of Histoplasma capsulatum glucans on host innate immunity

Autor: Edgar Zenteno, Noé Alvarado-Vásquez, Roberto Lara-Lemus, Patricia Gorocica

Publikováno v: Revista Iberoamericana de Micología. 31:76-80

β-1,3-Glucan is important for infective forms (mycelial phase) of Histoplasma capsulatum and shares many features allotted to pathogen-associated molecular patterns. These cell wall carbohydrates interact with phagocytes by binding to Toll and lecti

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https://doi.org/10.1016/j.riam.2013.10.005

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Correction to: Ouabain Accelerates Collective Cell Migration Through a cSrc and ERK1/2 Sensitive Metalloproteinase Activity

Autor: Teresita Padilla-Benavides, E. Perez Salazar, Rubén G. Contreras, Roberto Lara-Lemus, O. Verdejo-Torres, Jessica Campos Blázquez, Catalina Flores-Maldonado, Isabel Larre, Marcelino Cereijido

Publikováno v: The Journal of Membrane Biology. 252:561-561

The original version of the article unfortunately contained an error in the author group. Dr. Isabel Larre was not submitted and published in the original version.

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https://doi.org/10.1007/s00232-019-00077-2

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Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

Autor: Ming Liu, Leena Haataja, Gautam Rajpal, Israel Hodish, Jordan J. Wright, Peter Arvan, Roberto Lara-Lemus

Publikováno v: Trends in Endocrinology & Metabolism. 21:652-659

Type 1B diabetes (typically with early onset and without islet autoantibodies) has been described in patients bearing small coding sequence mutations in the INS gene. Not all mutations in the INS gene cause the autosomal dominant Mutant INS-gene Indu

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https://doi.org/10.1016/j.tem.2010.07.001

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The mitochondrial O-linked N-acetylglucosamine transferase (mOGT) in the diabetic patient could be the initial trigger to develop Alzheimer disease

Autor: Liliana Lozano, Noé Alvarado-Vásquez, Edgar Zenteno, Roberto Lara-Lemus

Publikováno v: Experimental gerontology. 58

Diabetes mellitus (DM) is considered a risk factor for the development of Alzheimer disease (AD); however, how DM favors evolution of AD is still insufficiently understood. Hyperglycemia in DM is associated to an increase in mitochondrial reactive ox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47423eba9373b47e7cee7db8147e620b
https://pubmed.ncbi.nlm.nih.gov/25148700

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Glucosamine-6-phosphate deaminase from beef kidney is an allosteric system of the V-type

Autor: Mario L. Calcagno, Roberto Lara-Lemus

Publikováno v: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1388:1-9

The enzyme glucosamine-6-phosphate deaminase from beef kidney has been purified to homogeneity by allosteric-site affinity chromatography. Its amino acid composition and the N-terminal sequence (1-42), were obtained. The amino acid sequence of this s

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https://doi.org/10.1016/s0167-4838(98)00141-1

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Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes

Autor: Shu-ou Shan, Fabrizio Barbetti, Roberto Lara-Lemus, Ming Liu, Leena Haataja, Huan Guo, Dennis Larkin, Peter Arvan, Jordan J. Wright

Publikováno v: Diabetes

Recently, missense mutations upstream of preproinsulin’s signal peptide (SP) cleavage site were reported to cause mutant INS gene-induced diabetes of youth (MIDY). Our objective was to understand the molecular pathogenesis using metabolic labeling

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http://hdl.handle.net/2108/55345

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Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

Publikováno v: Diabetes
Diabetes, American Diabetes Association, 2009, 58 (9), pp.2070-2083. ⟨10.2337/db09-0551⟩
Diabetes, American Diabetes Association, 2009, 58 (9), pp.2070-2083. 〈10.2337/db09-0551〉
Diabetes, 2009, 58 (9), pp.2070-2083. ⟨10.2337/db09-0551⟩

OBJECTIVE Zinc ions are essential for the formation of hexameric insulin and hormone crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8, is associated w

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https://www.hal.inserm.fr/inserm-00410150

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