Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Roberto I. Melendez"'
Autor:
Christian Bravo-Rivera, Kelvin Quiñones-Laracuente, Gregory J. Quirk, Marán Y. Hernández-Rodríguez, Roberto I. Melendez
Publikováno v:
Psychopharmacology
Rationale There is a high degree of comorbidity between alcohol use disorder and post-traumatic stress disorder (PTSD), but little is known about the interactions of ethanol with traumatic memories. Objectives Using auditory fear conditioning in rats
Publikováno v:
Progress in Neurobiology. 130:29-70
The ventral pallidum (VP) plays a critical role in the processing and execution of motivated behaviors. Yet this brain region is often overlooked in published discussions of the neurobiology of mental health (e.g., addiction, depression). This contri
Autor:
José A. Lasalde-Dominicci, Coral M. Capó-Vélez, Roberto I. Melendez, Edwin Vázquez-Rosa, José R. Mercado, Félix M. Ramos, Leomar Ballester, Wilfredo F. García-Beltrán, Raymond Rios
Publikováno v:
Journal of Biological Chemistry. 287:3079-3086
Approximately 30–50% of the >30 million HIV-infected subjects develop neurological complications ranging from mild symptoms to dementia. HIV does not infect neurons, and the molecular mechanisms behind HIV-associated neurocognitive decline are not
Publikováno v:
Addiction Biology. 17:351-364
Neuroadaptations that participate in the ontogeny of alcohol dependence are likely a result of altered gene expression in various brain regions. The present study investigated brain region-specific changes in the pattern and magnitude of gene express
Autor:
Alejandra M. Pacchioni, Roberto I. Melendez, Andy Y. Shih, Joseph Vallone, Timothy H. Murphy, Peter W. Kalivas
Publikováno v:
Brain Research. 1127:26-35
The transcription factor NF-E2-related factor (Nrf2) regulates the induction of phase 2 detoxifying enzymes by oxidative stress, including synthesis of the catalytic subunit (xCT) of the heterodimeric cystine-glutamate exchanger (system xc-). Repeate
Publikováno v:
Journal of neurovirology. 22(3)
The mechanisms leading to the neurocognitive deficits in humans with immunodeficiency virus type 1 (HIV-1) are not well resolved. A number of cell culture models have demonstrated that the HIV-envelope glycoprotein 120 (gp120) decreases the reuptake
Publikováno v:
Alcoholism: Clinical and Experimental Research. 30:2017-2025
Background: Relapse-like drinking has been studied through the expression of the alcohol deprivation effect (ADE), which is measured by a pronounced increase in ethanol preference and consumption after imposed abstinence. No studies have characterize
Publikováno v:
The Journal of Neuroscience. 25:6389-6393
Withdrawal from chronic cocaine reduces extracellular glutamate levels in the nucleus accumbens by decreasing cystine/glutamate exchange (xc-). Activating xc- withN-acetylcysteine restores extracellular glutamate and prevents cocaine-induced drug see
Publikováno v:
Alcoholism: Clinical & Experimental Research. 29:326-333
Background: An increased level of extracellular glutamate is a key neurochemical feature associated with ethanol exposure and withdrawal. Methods: In the current study, extracellular levels of glutamate and glutamate transport in the nucleus accumben
Publikováno v:
Neuropsychopharmacology. 29:1980-1987
Rearing rats in impoverished (IC) and enriched (EC) environmental conditions alters synaptic plasticity and cognitive processes. Metabotropic glutamate receptors (mGluRs) are known to play a key role in synaptic and behavioral plasticity. In the pres