i-Motif folding intermediates with zero-nucleotide loops are trapped by 2′-fluoroarabinocytidine via F···H and O···H hydrogen bonds

Autor: Roberto El-Khoury, Veronica Macaluso, Christopher Hennecker, Anthony K. Mittermaier, Modesto Orozco, Carlos González, Miguel Garavís, Masad J. Damha

Publikováno v: Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)

The oligonucleotide d(TC5) forms a well-characterized tetrameric i-motif in solution; however, the isolation of dimeric and trimeric intermediates remains challenging. Here, the authors report that 2′-deoxy-2′-fluoroarabinocytidine substitutions

Externí odkaz: https://doaj.org/article/4633b3ce480d4d24a7df7ba24c55d47e

End-ligation can dramatically stabilize i-motifs at neutral pH

Autor: Roberto El-Khoury, Masad J. Damha

Publikováno v: Chemical Communications. 59:3715-3718

We report the significant stabilization of i-motifs at neutral pH due to end-ligation. The effect is even more pronounced when 2′-fluoroarabinocytidine substitutions are utilized in conjunction with end-ligation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2d30523866083483ff178f0fcef2148
https://doi.org/10.1039/d2cc07063d

Recent progress in non-native nucleic acid modifications

Autor: Masad J. Damha, Marcel Hollenstein, James D. Thorpe, Roberto El-Khoury, Luke K. McKenzie

Publikováno v: Chemical Society Reviews
Chemical Society Reviews, Royal Society of Chemistry, 2021, 50 (8), pp.5126-5164. ⟨10.1039/D0CS01430C⟩
Chemical Society Reviews, 2021, 50 (8), pp.5126-5164. ⟨10.1039/D0CS01430C⟩

International audience; While Nature harnesses RNA and DNA to store, read and write genetic information, the inherent programmability, synthetic accessibility and wide functionality of these nucleic acids make them attractive tools for use in a vast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef62c7f28203b743325772d091a31d1
https://doi.org/10.1039/d0cs01430c

Author response: A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

Autor: Carlos González, Christopher G. Tomlinson, Masad J. Damha, Tracy M. Bryan, Jessica K Holien, Aaron L. Moye, Monica L. Birrento, Siritron Samosorn, Bishnu P. Paudel, Scott B. Cohen, Hala Abou Assi, Roberto El-Khoury, Kamthorn Intharapichai, Jennifer L. Beck, Marie-Paule Teulade-Fichou, Antoine M. van Oijen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f476400039ddd4f3be7f40441accf33
https://doi.org/10.7554/elife.56428.sa2

[C–H⋯anion] interactions mediate the templation and anion binding properties of topologically non-trivial metal–organic structures in aqueous solutions

Autor: Rana A. Bilbeisi, Mourad Elhabiri, Ali Trabolsi, John Carl Olsen, Loïc J. Charbonnière, Roberto El Khoury, Carlos Platas-Iglesias, Matteo Lusi, Thirumurugan Prakasam

Publikováno v: RUC. Repositorio da Universidade da Coruña
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[Abstract] Two synthetic approaches—temperature variation and anion templation—allowed for the selective formation of a [2]catenane ([2]C4+) or a trefoil knot (TK6+), or for the enhanced formation of a Solomon link (SL8+), all from a simple set o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ff56d3eba2d8bb269137d7ed2923c4
https://doi.org/10.1039/c5sc04246a