Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Roberto E. Guzman"'
Autor:
Jonathan Werner, Paul W. Snyder, Sarah H. Tannehill-Gregg, W. A. Craven, Nancy E. Everds, Roberto E. Guzman
Publikováno v:
Toxicologic pathology. 44(6)
Terminal body weights (TBWs), thymus weight parameters, and thymus morphology were retrospectively evaluated in 453 cynomolgus monkeys assigned to control groups on nonclinical toxicity studies. Morphology of bone, ovary, and testis/epididymis were u
Publikováno v:
Toxicologic Pathology. 39:410-413
Amylase-resistant, periodic acid-Schiff (PAS)–positive inclusions were identified in the skeletal muscle of four of twenty-four purpose-bred beagle dogs from a routine toxicology study. Affected myofibers contained amorphous material filling up to
Publikováno v:
Pathobiology. 76:199-203
Mice that are homozygous for the recessive osteopetrosis spontaneous mutation (op/op) develop severe osteopetrosis due to a defect in the production of macrophage colony-stimulating factor (M-CSF) and a deficiency in monocyte-derived osteoclasts. Our
Autor:
Roberto E. Guzman, Zaher A. Radi
Publikováno v:
Toxicologic Pathology. 35:296-299
Chronic lymphocytic thyroiditis characterized by multifocal follicular lymphoid cell infiltrates with germinal centers, thyroid acinar atrophy and pituitary cell hyperplasia/hypertrophy of the adenohypophysis was detected in a vehicle control, 4-year
Autor:
Andrew Tasker, Pedro J. Beltran, Darren L. Reid, Robert Radinsky, Jian J. Chen, Dina A. Andrews, David J. St. Jean, Keegan Cooke, Ryan Wurz, Tian Wu, Nataraj Kalyanaraman, Essa Hu-Harrington, Faye Hsieh, Simon J. Hedley, Kristin L. Andrews, Brad Herberich, Nancy E. Everds, Seifu Tadesse, Michele Kubryk, Jinghui Zhan, Jason S. Tedrow, Kate Ashton, Petia Mitchell, Andrew T. Parsons, Roberto E. Guzman, Liping H. Pettus, James Brown, Dean Hickman, Tom Nguyen, Matthew S. Potter, Edward K. Lobenhofer, David Bauer, Fang-Tsao Hong, Oliver R. Thiel
Publikováno v:
ACS medicinal chemistry letters. 6(9)
In nonsmall cell lung cancer (NSCLC), the threonine(790)-methionine(790) (T790M) point mutation of EGFR kinase is one of the leading causes of acquired resistance to the first generation tyrosine kinase inhibitors (TKIs), such as gefitinib and erloti
Autor:
Roberto E. Guzman, Kenneth S. Kilgore, Susan L. Calcaterra, D.J Schrier, Susan E. Bove, C.M Huber, Rachel M. Brooker, P.L. Juneau
Publikováno v:
Osteoarthritis and Cartilage. 11:821-830
Objective: To describe an in vivo model in the rat in which change in weight distribution is used as a measure of disease progression and efficacy of acetaminophen and two nonsteroidal anti-inflammatory drugs (NSAIDs) in a model of monosodium iodoace
Autor:
Roberto E. Guzman, Philip F. Solter
Publikováno v:
Veterinary Pathology. 39:17-26
Microcystin-LR (MCLR) is a potent hepatotoxin produced by the cyanobacterium Microcystis aeruginosa. The histology of acute lethal toxicity has been well characterized, but histology is limited regarding sublethal exposure. Balb/C mice were given a s
Autor:
Philip F. Solter, Roberto E. Guzman
Publikováno v:
Toxicologic Pathology. 27:582-588
Microcystin LR (MCLR) is a naturally occurring protein phosphatase inhibitor and potent hepatotoxin produced by strains of Microcystis aeruginosa. Although its acute toxicity has been well characterized, little is known about its chronic effects. In
Autor:
James R. Turk, John T. Payne, John W. Drexler, Gerry M. Henningsen, Ross P. Cowart, Steven L. Stockham, Roberto E. Guzman, Christopher P. Weis, Matthew F. Starost, Stan W. Casteel, William J. Brattin, Stephen V. Becker, Eva J. Hoffman
Publikováno v:
Fundamental and Applied Toxicology. 36:177-187
Bioavailability of lead (Pb) has become an issue in quantifying exposure of sensitive populations and, where necessary, establishing cleanup levels for contaminated soil. Immature swine were used as a model for young children to estimate the degree t
Publikováno v:
Immunopharmacology and Immunotoxicology. 19:279-289
Sera obtained from a group of pigs (n = 5) fed a diet amended with fumonisin containing Fusarium moniliforme culture material was used to determine the levels of Tumor Necrosis Factor-Alpha (TNF) activity by a functional bioassay utilizing the TNF se