Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Roberto Di Niro"'
Autor:
Grace A. McCarthy, Aditi Jain, Roberto Di Niro, Christopher W. Schultz, Wei Jiang, Charles J Yeo, Jessica Bowers, Jennifer Finan, Kelly Rhodes, Lou Casta, Vivi Hou, Anthony Stefanoni, Samantha Z. Brown, Avinoam Nevler, Lebaron C. Agostini, Lori Getts, Robert Getts, Jonathan R. Brody
Publikováno v:
Translational Oncology, Vol 32, Iss , Pp 101662- (2023)
Introduction: Standard-of-care systemic chemotherapies for pancreatic ductal adenocarcinoma (PDAC) currently have limited clinical benefits, in addition to causing adverse side effects in many patients. One factor known to contribute to the poor chem
Externí odkaz:
https://doaj.org/article/1a3343d576a846809073e9eb6d5af670
Autor:
Anna Vangone, Safwat Abdel-Azeim, Ivana Caputo, Daniele Sblattero, Roberto Di Niro, Luigi Cavallo, Romina Oliva
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102839 (2014)
Anti-idiotype antibodies have potential therapeutic applications in many fields, including autoimmune diseases. Herein we report the isolation and characterization of AIM2, an anti-idiotype antibody elicited in a mouse model upon expression of the ce
Externí odkaz:
https://doaj.org/article/20cc86a363084972a05f4aec70c7c3cd
Autor:
Grace A McCarthy, Roberto Di Niro, Jennifer M Finan, Aditi Jain, Yifei Guo, Cory R Wyatt, Alexander R Guimaraes, Trent A Waugh, Dove Keith, Terry K Morgan, Rosalie C Sears, Jonathan R Brody
Publikováno v:
NAR Cancer. 5
Stromal cells promote extensive fibrosis in pancreatic ductal adenocarcinoma (PDAC), which is associated with poor prognosis and therapeutic resistance. We report here for the first time that loss of the RNA-binding protein human antigen R (HuR, ELAV
Autor:
Samantha Z. Brown, Grace A. McCarthy, James R. Carroll, Roberto Di Niro, Carl Pelz, Aditi Jain, Thomas L. Sutton, Hannah D. Holly, Avinoam Nevler, Christopher W. Schultz, Matthew D. McCoy, Joseph A. Cozzitorto, Wei Jiang, Charles J. Yeo, Dan A. Dixon, Rosalie C. Sears, Jonathan R. Brody
Publikováno v:
Mol Cell Biol
Yes-associated protein 1 (YAP1) is indispensable for the development of mutant KRAS-driven pancreatic ductal adenocarcinoma (PDAC). High YAP1 mRNA is a prognostic marker for worse overall survival in patient samples; however, the regulatory mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0646e63136af2de9fef9b3d40a3ae0de
https://europepmc.org/articles/PMC9302082/
https://europepmc.org/articles/PMC9302082/
Publikováno v:
Cancer Research. 82:3137-3137
Many solid tumors, including pancreatic ductal adenocarcinoma (PDAC) tumors, rely on pro-tumorigenic intercellular paracrine signaling during tumor progression. Extensive work has been done to understand paracrine signaling via cytokines, chemokines,
Autor:
Beth L. Worley, Katherine Pelz, Grace McCarthy, Heike Mendez, Roberto Di Niro, Alex Chitsazan, Jonathan Brody, Aaron Grossberg
Publikováno v:
Cancer Research. 82:2373-2373
Objective: Cachexia, a wasting condition defined by chronic loss of fat and muscle, is a frequent complication of pancreatic ductal adenocarcinoma (PDAC) that negatively impacts quality of life and confers poor patient survival. Cachectic wasting can
Autor:
Jason A. Vander Heiden, Adrian W. Briggs, Tamara J. Gilbert, Francois Vigneault, Mark J. Shlomchik, Kevin C. O’Connor, Roberto Di Niro, Kris Adams, Ang Cui, Steven H. Kleinstein
Publikováno v:
The Journal of Immunology. 197:3566-3574
Analyses of somatic hypermutation (SHM) patterns in B cell Ig sequences have important basic science and clinical applications, but they are often confounded by the intrinsic biases of SHM targeting on specific DNA motifs (i.e., hot and cold spots).
Igs as Substrates for Transglutaminase 2: Implications for Autoantibody Production in Celiac Disease
Publikováno v:
The Journal of Immunology. 195:5159-5168
Autoantibodies specific for the enzyme transglutaminase 2 (TG2) are a hallmark of the gluten-sensitive enteropathy celiac disease. Production of the Abs is strictly dependent on exposure to dietary gluten proteins, thus raising the question how a for
Autor:
M. Fleur du Pré, Michael Morrissey, Min Huang, Knut E.A. Lundin, Roberto Di Niro, Patrick C. Wilson, Luka Mesin, Jorunn Stamnaes, Nai-Ying Zheng, Rasmus Iversen, Shuo-Wang Qiao, Jane-Hwei Lee, Ludvig M. Sollid
Publikováno v:
Nature Medicine
Nature medicine
Nature medicine
Celiac disease is an immune-mediated disorder in which mucosal autoantibodies to the enzyme transglutaminase 2 (TG2) are generated in response to the exogenous antigen gluten in individuals who express human leukocyte antigen HLA-DQ2 or HLA-DQ8 (ref.
Publikováno v:
The Journal of Immunology. 187:2867-2874
To understand the biology of Ab-secreting cells in the human small intestine, we examined Ab production of intestinal biopsies kept in culture. We found sustained IgA and IgM secretion as well as viable IgA- or IgM-secreting cells after >4 wk of cult