Zobrazeno 1 - 10 of 166 pro vyhledávání: '"Roberto Cotellese"'
1
Akademický článek
Differential Regulation of Wingless-Wnt/c-Jun N-Terminal Kinase Crosstalk via Oxidative Eustress in Primary and Metastatic Colorectal Cancer Cells
Autor: Gitana Maria Aceto, Sara Pagotto, Francesco Domenico Del Pizzo, Concetta Saoca, Federico Selvaggi, Rosa Visone, Roberto Cotellese, M’hammed Aguennouz, Rossano Lattanzio, Teresa Catalano
Publikováno v: Biomedicines, Vol 12, Iss 8, p 1816 (2024)
In the tumor microenvironment (TME), ROS production affects survival, progression, and therapy resistance in colorectal cancer (CRC). H2O2-mediated oxidative stress can modulate Wnt/β-catenin signaling and metabolic reprogramming of the TME. Current
Externí odkaz: https://doaj.org/article/4243d0169bf34fb0939aa9a6ba6ca21b
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2
Akademický článek
Infectious Agents Induce Wnt/β-Catenin Pathway Deregulation in Primary Liver Cancers
Autor: Teresa Catalano, Federico Selvaggi, Diana Liberata Esposito, Roberto Cotellese, Gitana Maria Aceto
Publikováno v: Microorganisms, Vol 11, Iss 7, p 1632 (2023)
Interaction between infectious agents and liver tissue, as well as repeated and extreme biological events beyond adaptive capacities, may result in pathological conditions predisposing people to development of primary liver cancers (PLCs). In adults,
Externí odkaz: https://doaj.org/article/0bd960ffd53a48a9b9d23cfdd2c95274
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3
Akademický článek
Effects of H2O2 Treatment Combined With PI3K Inhibitor and MEK Inhibitor in AGS Cells: Oxidative Stress Outcomes in a Model of Gastric Cancer
Autor: Luca Savino, Maria Carmela Di Marcantonio, Carmelo Moscatello, Roberto Cotellese, Lucia Centurione, Raffaella Muraro, Gitana Maria Aceto, Gabriella Mincione
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
Gastric cancer is worldwide the fifth and third cancer for incidence and mortality, respectively. Stomach wall is daily exposed to oxidative stress and BER system has a key role in the defense from oxidation-induced DNA damage, whilst ErbB receptors
Externí odkaz: https://doaj.org/article/254c6f520a714b36b754e4f5b26fa8cc
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5
Akademický článek
Emerging Role of Oxidative Stress on EGFR and OGG1-BER Cross-Regulation: Implications in Thyroid Physiopathology
Autor: Carmelo Moscatello, Maria Carmela Di Marcantonio, Luca Savino, Emira D’Amico, Giordano Spacco, Pasquale Simeone, Paola Lanuti, Raffaella Muraro, Gabriella Mincione, Roberto Cotellese, Gitana Maria Aceto
Publikováno v: Cells, Vol 11, Iss 5, p 822 (2022)
Thyroid diseases have a complex and multifactorial aetiology. Despite the numerous studies on the signals referable to the malignant transition, the molecular mechanisms concerning the role of oxidative stress remain elusive. Based on its strong oxid
Externí odkaz: https://doaj.org/article/96e21e925a8544f09338867bab5fedc3
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