Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Roberto Calcedo"'
Autor:
Jenny A. Greig, Roberto Calcedo, Leticia Kuri-Cervantes, Jayme M.L. Nordin, Jessica Albrecht, Erin Bote, Tamara Goode, Edward A. Chroscinski, Peter Bell, Laura K. Richman, Michael R. Betts, James M. Wilson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 11, Iss , Pp 191-201 (2018)
Systemic delivery of adeno-associated viral (AAV) vectors has been evaluated for the treatment of several liver diseases, including homozygous familial hypercholesterolemia, ornithine transcarbamylase deficiency, and hemophilia. Here, we evaluated th
Externí odkaz:
https://doaj.org/article/01118e8f567e49fb8ab1d3079ca6e907
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
With the advent of single B-cell cloning technology, we can isolate antibodies against virtually any antigen to study the interaction of a given pathogen with the immune system and develop novel therapeutic strategies. Antibodies directed against the
Externí odkaz:
https://doaj.org/article/27a75fe7cf724aa8bc7cfb70b51a40b5
Autor:
Juliette Hordeaux, Christian Hinderer, Tamara Goode, Nathan Katz, Elizabeth L. Buza, Peter Bell, Roberto Calcedo, Laura K. Richman, James M. Wilson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 79-88 (2018)
Mucopolysaccharidosis type I is a recessive genetic disease caused by deficiency of the lysosomal enzyme α-L-iduronidase, which leads to a neurodegenerative and systemic disease called Hurler syndrome in its most severe form. Several clinical trials
Externí odkaz:
https://doaj.org/article/1f37efe1f3c9466eaf96059d5c8d3fc8
Autor:
Juliette Hordeaux, Christian Hinderer, Tamara Goode, Elizabeth L. Buza, Peter Bell, Roberto Calcedo, Laura K. Richman, James M. Wilson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 68-78 (2018)
Hunter syndrome is an X-linked recessive disease caused by deficiency of the lysosomal enzyme iduronate-2-sulfatase. The severe form of this progressive, systemic, and neurodegenerative disease results in loss of cognitive skills and early death. Sev
Externí odkaz:
https://doaj.org/article/5a204333500b4ac4af8e689cf632c042
Autor:
Eric WFW Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield, Diana Bilton, Emily V Bloomfield, A Christopher Boyd, June Brand, Ruaridh Buchan, Roberto Calcedo, Paula Carvelli, Mario Chan, Seng H Cheng, David S Collie, Steve Cunningham, Heather E Davidson, Gwyneth Davies, Jane C Davies, Lee A Davies, Maria H Dewar, Ann Doherty, Jackie Donovan, Natalie S Dwyer, Hala I Elgmati, Rosanna F Featherstone, Jemyr Gavino, Sabrina Gea-Sorli, Duncan M Geddes, James SR Gibson, Deborah R Gill, Andrew P Greening, Uta Griesenbach, David M Hansell, Katharine Harman, Tracy E Higgins, Samantha L Hodges, Stephen C Hyde, Laura Hyndman, J Alastair Innes, Joseph Jacob, Nancy Jones, Brian F Keogh, Maria P Limberis, Paul Lloyd-Evans, Alan W Maclean, Michelle C Manvell, Dominique McCormick, Michael McGovern, Gerry McLachlan, Cuixiang Meng, M Angeles Montero, Hazel Milligan, Laura J Moyce, Gordon D Murray, Andrew G Nicholson, Tina Osadolor, Javier Parra-Leiton, David J Porteous, Ian A Pringle, Emma K Punch, Kamila M Pytel, Alexandra L Quittner, Gina Rivellini, Clare J Saunders, Ronald K Scheule, Sarah Sheard, Nicholas J Simmonds, Keith Smith, Stephen N Smith, Najwa Soussi, Samia Soussi, Emma J Spearing, Barbara J Stevenson, Stephanie G Sumner-Jones, Minna Turkkila, Rosa P Ureta, Michael D Waller, Marguerite Y Wasowicz, James M Wilson, Paul Wolstenholme-Hogg, on behalf of the UK Cystic Fibrosis Gene Therapy Consortium
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 3, Iss 5 (2016)
Background: Cystic fibrosis (CF) is a chronic, life-limiting disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene leading to abnormal airway surface ion transport, chronic lung infections, inflammation and eventual re
Externí odkaz:
https://doaj.org/article/09b29fe1b155492fba24a177fe4be24c
Autor:
Soumitra Roy, Roberto Calcedo, Angelica Medina-Jaszek, Martin Keough, Hui Peng, James M Wilson
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24859 (2011)
Persistent adenoviral shedding in stools is known to occur past convalescence following acute adenoviral infections. We wished to establish the frequency with which adenoviruses may colonize the gut in normal human subjects.The presence of adenoviral
Externí odkaz:
https://doaj.org/article/5ed2fcfa125043af849e082597adf07a
Autor:
Soumitra Roy, Luk H Vandenberghe, Sergey Kryazhimskiy, Rebecca Grant, Roberto Calcedo, Xin Yuan, Martin Keough, Arbans Sandhu, Qiang Wang, C Angelica Medina-Jaszek, Joshua B Plotkin, James M Wilson
Publikováno v:
PLoS Pathogens, Vol 5, Iss 7, p e1000503 (2009)
Adenoviruses are important human pathogens that have been developed as vectors for gene therapies and genetic vaccines. Previous studies indicated that human infections with adenoviruses are self-limiting in immunocompetent hosts with evidence of som
Externí odkaz:
https://doaj.org/article/a187d1dd44c14ebfa37d3108f48ede60
Publikováno v:
Mol Ther
Intra-arterial administration of an adenovirus serotype 5 (Ad5) vector in a gene therapy trial caused lethal, systemic inflammation in subject 019 with ornithine transcarbamylase deficiency. This unanticipated inflammatory response was absent in anot
Autor:
Jayme M.L. Nordin, Jenny A. Greig, Erin Bote, James M. Wilson, Peter Bell, Laura K. Richman, Roberto Calcedo, Leticia Kuri-Cervantes, Jessica Albrecht, Edward A. Chroscinski, Michael R. Betts, Tamara Goode
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 11, Iss, Pp 191-201 (2018)
Molecular Therapy: Methods & Clinical Development, Vol 11, Iss, Pp 191-201 (2018)
Systemic delivery of adeno-associated viral (AAV) vectors has been evaluated for the treatment of several liver diseases, including homozygous familial hypercholesterolemia, ornithine transcarbamylase deficiency, and hemophilia. Here, we evaluated th
Autor:
Roberto Calcedo, Jessica A. Chichester, Peter Bell, Mingyao Li, Tahsin Jahan, Juliette Hordeaux, Yuan Yuan, Yanqing Zhu, Brianne A. Jeffrey, Elizabeth L. Buza, James M. Wilson, Chunjuan Song
Publikováno v:
Science Translational Medicine. 12
Delivering adeno-associated virus (AAV) vectors into the central nervous system of nonhuman primates (NHPs) via the blood or cerebral spinal fluid is associated with dorsal root ganglion (DRG) toxicity. Conventional immune-suppression regimens do not