Zobrazeno 1 - 10 of 59 pro vyhledávání: '"Roberto C P Lima-Júnior"'
1
Akademický článek
The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis.
Autor: Deysi V T Wong, Roberto C P Lima-Júnior, Cibele B M Carvalho, Vanessa F Borges, Carlos W S Wanderley, Amanda X C Bem, Caio A V G Leite, Maraiza A Teixeira, Gabriela L P Batista, Rangel L Silva, Thiago M Cunha, Gerly A C Brito, Paulo R C Almeida, Fernando Q Cunha, Ronaldo A Ribeiro
Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0139985 (2015)
Intestinal mucositis is a common side effect of irinotecan-based anticancer regimens. Mucositis causes cell damage, bacterial/endotoxin translocation and production of cytokines including IL-1 and IL-18. These molecules and toll-like receptors (TLRs)
Externí odkaz: https://doaj.org/article/70e4dd6593c243b0847fdb00138d362b
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2
Akademický článek
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
Autor: Carlo C. Campa, Rangel L. Silva, Jean P. Margaria, Tracey Pirali, Matheus S. Mattos, Lucas R. Kraemer, Diego C. Reis, Giorgio Grosa, Francesca Copperi, Eduardo M. Dalmarco, Roberto C. P. Lima-Júnior, Silvio Aprile, Valentina Sala, Federica Dal Bello, Douglas Silva Prado, Jose Carlos Alves-Filho, Claudio Medana, Geovanni D. Cassali, Gian Cesare Tron, Mauro M. Teixeira, Elisa Ciraolo, Remo C. Russo, Emilio Hirsch
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Activation of PI3K plays a role in pulmonary inflammation. Here, the authors develop a drug inhibitor of PI3K, and show that it inhibits lung inflammation and damage in mouse models of asthma and lung fibrosis.
Externí odkaz: https://doaj.org/article/ffd766e4bb69453a8c45e742f2d6dd75
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3
Akademický článek
The involvement of mast cells in the irinotecan-induced enteric neurons loss and reactive gliosis
Autor: Ludmila T. Nogueira, Deiziane V. S. Costa, Antoniella S. Gomes, Conceição S. Martins, Angeline M. H. P. Silva, Juliana M. Coelho-Aguiar, Patrícia Castelucci, Roberto C. P. Lima-Júnior, Renata F. C. Leitão, Vivaldo Moura-Neto, Gerly A. C. Brito
Publikováno v: Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-13 (2017)
Abstract Background The irinotecan (CPT-11) causes intestinal mucositis and diarrhea that may be related to changes in the enteric nervous system (ENS). In inflammatory condition, mast cells release a variety of pro-inflammatory mediators that can in
Externí odkaz: https://doaj.org/article/526ce3b232ef45f98272d97dea8e1a60
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4
Akademický článek
The Alpha-Lipoic Acid Improves Survival and Prevents Irinotecan-Induced Inflammation and Intestinal Dysmotility in Mice
Autor: Daniely V. S. Costa, Deiziane V. S. Costa, Caren N. S. Sousa, Angeline M. H. P. Silva, Ingridy S. Medeiros, Dainesy S. Martins, Conceição S. Martins, Ana L. V. Pequeno, Roberto C. P. Lima-Júnior, Pedro M. G. Soares, Silvânia M. M. Vasconcelos, Gerly A. C. Brito, Emmanuel P. Souza
Publikováno v: Pharmaceuticals, Vol 13, Iss 11, p 361 (2020)
Irinotecan, an anticancer drug, induces diarrhea and intestinal inflammation, resulting in an increase in the cost of care and in treatment delays. In this study, we investigated whether alpha-lipoic acid (α-LA) could improve irinotecan-mediated int
Externí odkaz: https://doaj.org/article/17655df1f53a4cd781bffb8d484a1624
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5
Endocannabinoid System Attenuates Oxaliplatin-Induced Peripheral Sensory Neuropathy Through the Activation of CB1 Receptors
Autor: Bruno Wesley de Freitas Alves, Jaime Eduardo Cecílio Hallak, Mariana Lima Vale, Jonas Costa de França, Mario Roberto Pontes Lisboa, José Alexandre de Souza Crippa, Antonio Waldo Zuardi, Cristiane Maria Pereira da Silva, Roberto C. P. Lima-Júnior, Francisco Rafael Alves Santana Cesário, Diego Bernarde Souza Dias, Anamaria Falcão Pereira, Nylane M.N. Alencar, Amanda Rocha de Oliveira, Karoline Luanne Santos de Menezes
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Oxaliplatin-induced neurotoxicity is expressed as a dose-limiting peripheral sensory neuropathy (PSN). Cannabinoid substances have been investigated for the analgesic effect. This study aimed to investigate the role of cannabinoid receptors in oxalip
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d3b929c8d62756704c6a7a8f08ba8f
https://doi.org/10.1007/s12640-021-00442-x
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7
Successful Pre-Clinical Management of Irinotecan-Debilitated Animals: A Protein- Based Accessory Phytomedicine
Autor: Nylane M. N. Alencar, Márcio V. Ramos, Gisele F. P. Rangel, Luana D. do Carmo, Liviane M. A. Rabelo, Alfredo A. V. Silva, Tamiris F. G. de Sousa, Roberto C. P. Lima Júnior, Deysi V. T. Wong, Renata F. C. Leitão, Pedro J. C. Magalhães, Brandon F. Sousa, Marisa J. S. Frederico
Publikováno v: Anti-cancer agents in medicinal chemistry. 22(18)
Background: Calotropis procera is a laticiferous plant (Apocynaceae) found in tropical regions all over the world. The ultrastructural characteristics of laticifers, their restricted distribution among different taxonomic groups, and in some species
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760fb7724d14c6d6db2a964f0e1e236c
https://pubmed.ncbi.nlm.nih.gov/35692152
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8
Alanyl-glutamine Protects Against Damage Induced by Enteroaggregative Escherichia coli Strains in Intestinal Cells
Autor: Samilly A. Ribeiro, Mara M. G. Prata, Mayra A V Reyes, Richard L. Guerrant, Marco A F Clementino, Ila F. N. Lima, Roberto C. P. Lima-Júnior, Josiane da Silva Quetz, Paloma A. Cavalcante, Antonio Vinicios Alves da Silva, Eudmar M de Assis Júnior, Aldo A. M. Lima, Pedro H. Q. S. Medeiros, Alexandre Havt
Publikováno v: Journal of Pediatric Gastroenterology & Nutrition. 68:190-198
Background Enteroaggregative Escherichia coli (EAEC) is an important pathogen causing enteric infections worldwide. This pathotype is linked to malnutrition in children from developing countries. Alanyl-glutamine (Ala-Gln) is an immune modulator nutr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9026946a2c1c843cecf0053fee59609
https://doi.org/10.1097/mpg.0000000000002152
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9
5-Fluorouracil Induces Enteric Neuron Death and Glial Activation During Intestinal Mucositis via a S100B-RAGE-NFκB-Dependent Pathway
Autor: Richard L. Guerrant, Deiziane Viana da Silva Costa, Gerly Anne de Castro Brito, David T. Bolick, Vivaldo Moura-Neto, Angeline M. H. P. Silva, Conceição da Silva Martins, Ana Carina Bon-Frauches, Patricia Castelucci, Gutierrez B. Freitas, Roberto C. P. Lima-Júnior, Renata Ferreira de Carvalho Leitão, Cirle A. Warren
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports
Repositório Institucional da Universidade Federal do Ceará (UFC)
Universidade Federal do Ceará (UFC)
instacron:UFC
5-Fluorouracil (5-FU) is an anticancer agent whose main side effects include intestinal mucositis associated with intestinal motility alterations maybe due to an effect on the enteric nervous system (ENS), but the underlying mechanism remains unclear
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2b409362c807b200d628214d3b3307
http://link.springer.com/article/10.1038/s41598-018-36878-z
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