Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Roberto Bossi"'
Autor:
Daniele Donati, Andrea Lombardi Borgia, Ettore Perrone, Lucio Ceriani, Chiara Marchionni, Paolo Orsini, Marcella Nesi, Luisa Rusconi, Paola Magnaghi, Marina Fasolini, Nilla Avanzi, G. Canevari, Arturo Galvani, Maristella Colombo, Patrizia Banfi, Elena Ardini, Laura Buffa, Antonella Isacchi, Christian Orrenius, Roberto Bossi, Maria Beatrice Saccardo, Ermes Vanotti, Claudio Fiorelli, Francesco Fiorentini, Maria Menichincheri, Achille Panzeri, Luca Corti, Enrico Pesenti, Eduard R. Felder
Publikováno v:
Journal of Medicinal Chemistry. 59:3392-3408
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase responsible for the development of different tumor types. Despite the remarkable clinical activity of crizotinib (Xalkori), the first ALK inhibitor approved in 2011, the emergence of resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc806429f7d1f3155f365de5d16bf20
https://doi.org/10.1021/acs.jmedchem.6b00064
https://doi.org/10.1021/acs.jmedchem.6b00064
Autor:
Roberto Bossi, Daniele Pezzetta, Gabriele Fachin, Barbara Forte, Alessandra Scolaro, Italo Beria, Walter Ceccarelli, Enrico Pesenti, Michele Caruso, Francesco Fiorentini, Stefania Re Depaolini, Marina Fasolini, Helena Posteri, Barbara Valsasina, Maria Gabriella Brasca
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2969-2974
As part of our drug discovery effort, we identified and developed 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as PLK1 inhibitors. We now report the optimization of this class that led to the identification of NMS-P937, a potent, selective a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb1c72f2e8179a8a325d3bbb4369e24
https://doi.org/10.1016/j.bmcl.2011.03.054
https://doi.org/10.1016/j.bmcl.2011.03.054
Autor:
Arturo Galvani, Maria Laura Giorgini, Nilla Avanzi, Luisa Rusconi, Francesco Sola, Riccardo Colombo, Paolo Cappella, Stefania Re Depaolini, Claudia Perrera, Antonella Isacchi, Daniele Donati, Francesco Colotta, Ulisse Cucchi, Roberto Bossi, Marina Caldarelli, Enrico Pesenti, Milena Mennecozzi, Jürgen Moll, J.A. Bertrand
Publikováno v:
Cancer Research. 70:10255-10264
MPS1 kinase is a key regulator of the spindle assembly checkpoint (SAC), a mitotic mechanism specifically required for proper chromosomal alignment and segregation. It has been found aberrantly overexpressed in a wide range of human tumors and is nec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1d4d987ed709eb7439c66638602f27
https://doi.org/10.1158/0008-5472.can-10-2101
https://doi.org/10.1158/0008-5472.can-10-2101
Autor:
Gabriele Fachin, Valter Croci, Michele Caruso, Roberto Bossi, Jurgen Moll, Jay Bertrand, Walter Ceccarelli, Dario Ballinari, Rita Perego, Anna De Ponti, Maurizio Rocchetti, Enrico Pesenti, Ron Ferguson, Barbara Valsasina, Maria Gabriella Brasca, Paolo Cappella, Daniela Borghi, Jacqueline Lansen, Helena Posteri, Antonella Ciavolella, Cinzia Cristiani, Italo Beria, Daniele Volpi, Paola Storici
Publikováno v:
Journal of medicinal chemistry. 53(9)
Polo-like kinase 1 (Plk1) is a fundamental regulator of mitotic progression whose overexpression is often associated with oncogenesis and therefore is recognized as an attractive therapeutic target in the treatment of proliferative diseases. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a1b1da3f270f65bb9890f0acb1be33
https://pubmed.ncbi.nlm.nih.gov/20397705
https://pubmed.ncbi.nlm.nih.gov/20397705
Autor:
Valeria Betti, Cappelletti Tiziana, Maria Allegra Romolotti, Valter Fasano, Chiara Baldessari, Roberto Bossi
Publikováno v:
Sleep Medicine. 7:S100-S101
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4786db6fa4e2cb4ad990a485774bfe1
https://doi.org/10.1016/j.sleep.2006.07.235
https://doi.org/10.1016/j.sleep.2006.07.235
Autor:
Chiara Baldessari, Valter Fasano, Valeria Betti, Roberto Bossi, Maria Allegra Romolotti, Tiziana Cappelletti
Publikováno v:
Sleep Medicine. 7:S49-S50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67749f499bf1a3fd268248690f1f855d
https://doi.org/10.1016/j.sleep.2006.07.128
https://doi.org/10.1016/j.sleep.2006.07.128
Autor:
Francesco Sola, Claudia Perrera, Nilla Avanzi, Paolo Cappella, Luisa Rusconi, Riccardo Colombo, Milena Mennecozzi, Roberto Bossi, Daniele Donati, Stefania Re Depaolini, Marina Caldarelli, Maria Laura Giorgini, Antonella Isacchi, Jürgen Moll, Jay Bertrand, Dario Ballinari, Enrico Pesenti, Daniele Volpi
Publikováno v:
Molecular Cancer Therapeutics. 8:C202-C202
The Spindle Assembly Checkpoint (SAC) is a mitotic mechanism specifically required for proper chromosomal segregation ensuring that cells do not divide until all sister chromatids correctly align to the metaphase plate. MPS1 kinase, (also known as TT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42e59f8cbe997aa7ce8f4d58299fe43a
https://doi.org/10.1158/1535-7163.targ-09-c202
https://doi.org/10.1158/1535-7163.targ-09-c202
Autor:
P. Storici, Marina Fasolini, Roberto Bossi, J.A. Bertrand, Barbara Valsasina, S. Re Depaolini, N. Mongelli, Italo Beria, Michele Caruso, Rita Perego
Publikováno v:
European Journal of Cancer Supplements. 6:136
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74f1bafc2207c988cff93200b94d3633
https://doi.org/10.1016/s1359-6349(08)72367-x
https://doi.org/10.1016/s1359-6349(08)72367-x
Autor:
Maria Menichincheri, Alberto Bargiotti, Jens Berthelsen, Jay A. Bertrand, Roberto Bossi, Antonella Ciavolella, Alessandra Cirla, Cinzia Cristiani, Valter Croci, Roberto D’Alessio, Marina Fasolini, Francesco Fiorentini, Barbara Forte, Antonella Isacchi, Katia Martina, Antonio Molinari, Alessia Montagnoli, Paolo Orsini, Fabrizio Orzi, Enrico Pesenti
Publikováno v:
Journal of Medicinal Chemistry; Feb2009, Vol. 52 Issue 4, p1230-1230, 1p