Mathematical modelling reveals unexpected inheritance and variability patterns of cell cycle parameters in mammalian cells.

Autor: Marzena Mura, Céline Feillet, Roberto Bertolusso, Franck Delaunay, Marek Kimmel

Publikováno v: PLoS Computational Biology, Vol 15, Iss 6, p e1007054 (2019)

The cell cycle is the fundamental process of cell populations, it is regulated by environmental cues and by intracellular checkpoints. Cell cycle variability in clonal cell population is caused by stochastic processes such as random partitioning of c

Externí odkaz: https://doaj.org/article/396270e48b514226aa373462281b0da3

Dynamic cross talk model of the epithelial innate immune response to double-stranded RNA stimulation: coordinated dynamics emerging from cell-level noise.

Autor: Roberto Bertolusso, Bing Tian, Yingxin Zhao, Leoncio Vergara, Aqeeb Sabree, Marta Iwanaszko, Tomasz Lipniacki, Allan R Brasier, Marek Kimmel

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93396 (2014)

We present an integrated dynamical cross-talk model of the epithelial innate immune response (IIR) incorporating RIG-I and TLR3 as the two major pattern recognition receptors (PRR) converging on the RelA and IRF3 transcriptional effectors. bioPN simu

Externí odkaz: https://doaj.org/article/e207d84aaa0f41919778d7f3225b8a09

Mathematical modelling reveals unexpected inheritance and variability patterns of cell cycle parameters in mammalian cells

Autor: Celine Feillet, Roberto Bertolusso, Marek Kimmel, Franck Delaunay, Marzena Mura

Publikováno v: PLoS Computational Biology
PLoS Computational Biology, Public Library of Science, 2019, 15 (6), pp.e1007054. ⟨10.1371/journal.pcbi.1007054⟩
PLoS Computational Biology, 2019, 15 (6), pp.e1007054. ⟨10.1371/journal.pcbi.1007054⟩
PLoS Computational Biology, Vol 15, Iss 6, p e1007054 (2019)

The cell cycle is the fundamental process of cell populations, it is regulated by environmental cues and by intracellular checkpoints. Cell cycle variability in clonal cell population is caused by stochastic processes such as random partitioning of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8a4a39dc80596cb04e9e6ce66138b2
https://www.hal.inserm.fr/inserm-02275878/document

Modeling Spatial Effects in Early Carcinogenesis : Stochastic Versus Deterministic Reaction-Diffusion Systems

Autor: Marek Kimmel, Roberto Bertolusso

Publikováno v: Mathematical Modelling of Natural Phenomena. 7:245-260

We consider the early carcinogenesis model originally proposed as a deterministic reaction-diffusion system. The model has been conceived to explore the spatial effects stemming from growth regulation of pre-cancerous cells by diffusing growth factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aec93e481f5a4db2249fae9bb8121b48
https://doi.org/10.1051/mmnp/20127111

Influence of Gender on Age of Treatment with TKA and Functional Outcome

Autor: Roberto Bertolusso, Melvyn A. Harrington, Brian S. Parsley, Philip C. Noble, Adam Brekke

Publikováno v: Clinical Orthopaedics & Related Research. 468:1759-1764

Previous studies suggest differences may exist between men and women in terms of knee function before and after total knee replacement. This may be related to the efficacy of the procedure itself or to differences in the severity of disability of mal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a877b620fb7d8839c8a558ca93031d5
https://doi.org/10.1007/s11999-010-1348-y