Ferulated Poly(vinyl alcohol) based hydrogels

Autor: Simone Pepi, Marco Paolino, Mario Saletti, Jacopo Venditti, Luigi Talarico, Marco Andreassi, Germano Giuliani, Gianfranco Caselli, Roberto Artusi, Andrea Cappelli, Gemma Leone, Agnese Magnani, Lucio Rovati

Publikováno v: Heliyon, Vol 9, Iss 11, Pp e22330- (2023)

New graft copolymers were prepared by reaction of poly (vinyl alcohol) (PVA) with mono-imidazolide or bis-imidazolide derivatives of ferulic acid (FA) with the formation of ester bonds. The obtained graft copolymers, thanks to the crosslinking capabi

Externí odkaz: https://doaj.org/article/db3ce5d41a274303a5bcc27fba30edec

Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors

Autor: Cinzia Maria Francini, Francesca Musumeci, Anna Lucia Fallacara, Lorenzo Botta, Alessio Molinari, Roberto Artusi, Laura Mennuni, Adriano Angelucci, Silvia Schenone

Publikováno v: Molecules, Vol 23, Iss 9, p 2369 (2018)

Protein kinases have emerged as crucial targets for cancer therapy over the last decades. Since 2001, 40 and 39 kinase inhibitors have been approved by FDA and EMA, respectively, and the majority are antineoplastic drugs. Morevoer, many candidates ar

Externí odkaz: https://doaj.org/article/0c35cc55b1d7482897fe671e6e6dc190

Abstract 4219: Efficacy of CR13626, a novel oral brain penetrant multi-kinase inhibitor, in a mouse model of glioblastoma

Autor: Tiziana Piepoli, Chiara Galimberti, Silvia Zerbi, Gianfranco Caselli, Roberto Artusi, Ornella Letari, Giuseppe M. Montagna, Milena Colovic, Stefano Persiani, Lucio C. Rovati

Publikováno v: Cancer Research. 80:4219-4219

BACKGROUND: Currently there is no cure for glioblastoma (GBM), the most malignant primary brain cancer. Glioblastoma etiopathogenesis involves mutations and alterations of key signaling pathways including tyrosine kinases (TKs). Notably, aberrant act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8c81f63475de9c7b7e402dc363b38ee
https://doi.org/10.1158/1538-7445.am2020-4219

Development of Imidazole-Reactive Molecules Leading to a New Aggregation-Induced Emission Fluorophore Based on the Cinnamic Scaffold

Autor: Francesca Villafiorita-Monteleone, Alessandro Donati, Gianfranco Caselli, Chiara Botta, Francesco Makovec, Michela Visintin, Annalisa Reale, Vincenzo Razzano, Andrea Cappelli, Germano Giuliani, Marco Paolino, Roberto Artusi

Publikováno v: ACS omega 2 (2017): 5453–5459. doi:10.1021/acsomega.7b00789
info:cnr-pdr/source/autori:V.Razzano, M. Paolino, A. Reale, G. Giuliani, R. Artusi, G. Caselli, M. Visintin, F. Makovec, A. Donati, F. Villafiorita-Monteleone, C. Botta, and A. Cappelli/titolo:Development of Imidazole-Reactive Molecules Leading to a New Aggregation-Induced Emission Fluorophore Based on the Cinnamic Scaffold/doi:10.1021%2Facsomega.7b00789/rivista:ACS omega/anno:2017/pagina_da:5453/pagina_a:5459/intervallo_pagine:5453–5459/volume:2
ACS Omega, Vol 2, Iss 9, Pp 5453-5459 (2017)
ACS Omega

In order to obtain new fluorophores potentially useful in imidazole labeling and subsequent conjugation, a small series of Morita- Baylis-Hillman acetates (3a-c) was designed, synthesized, and reacted with imidazole. The optical properties of the cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418addc151cc34caa785a1f71daeaaa7
http://www.cnr.it/prodotto/i/380650

Identification of Aminoimidazole and Aminothiazole Derivatives as Src Family Kinase Inhibitors

Autor: Alessia Calgani, Silvia Schenone, Adriano Angelucci, Anna Lucia Fallacara, Roberto Artusi, Laura Mennuni, Maurizio Botta, Cinzia Maria Francini

Publikováno v: ChemMedChem. 10(12)

Src family kinases (SFKs) are a family of non-receptor tyrosine kinases (TKs) implicated in the regulation of many cellular processes. The aberrant activity of these TKs has been associated with the growth and progression of cancer. In particular, c-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4ba00e07c220bc904d4c7d7fbd011fc
https://pubmed.ncbi.nlm.nih.gov/26514807