Synthesis of New 4-Aminoquinolines and Evaluation of Their In Vitro Activity against Chloroquine-Sensitive and Chloroquine-Resistant Plasmodium falciparum.

Autor: Chandima S K Rajapakse, Maryna Lisai, Christiane Deregnaucourt, Véronique Sinou, Christine Latour, Dipankar Roy, Joseph Schrével, Roberto A Sánchez-Delgado

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0140878 (2015)

The efficacy of chloroquine, once the drug of choice in the fight against Plasmodium falciparum, is now severely limited due to widespread resistance. Amodiaquine is one of the most potent antimalarial 4-aminoquinolines known and remains effective ag

Externí odkaz: https://doaj.org/article/3bc29ab0c6824dac9435be1c6d4d2736

Synthesis of an organo-ruthenium aminoquinoline-trioxane hybrid and evaluation of its activity against Plasmodium falciparum and its toxicity toward normal mammalian cells

Autor: Alberto Martínez, Christiane Deregnaucourt, Joseph Schrevel, Véronique Sinou, Christine Latour, Roberto A. Sánchez-Delgado, Dipankar Roy

Publikováno v: Medicinal Chemistry Research
Medicinal Chemistry Research, 2017, 26 (2), pp.473-483. ⟨10.1007/s00044-016-1769-6⟩
Medicinal Chemistry Research, Springer Verlag, 2017, 26 (2), pp.473-483. ⟨10.1007/s00044-016-1769-6⟩

A new hybrid compound 5 containing a ruthenocene, a 4-aminoquinoline, and a 1,2,4-trioxane within a single molecular structure has been synthesized and evaluated for antimalarial potential. In order to ascertain the role of each component of hybrid 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5fe9cd593156af61fa5e02f03d0cf6a
https://mnhn.hal.science/mnhn-02878030

Hydrogenation of arenes, N-heteroaromatic compounds, and alkenes catalyzed by rhodium nanoparticles supported on magnesium oxide

Autor: Minfeng Fang, Roberto A. Sánchez-Delgado, Antonio Sánchez, Atif Ahmed

Publikováno v: Applied Catalysis A: General. 477:117-124

A new catalyst composed of Rh nanoparticles supported on magnesium oxide was prepared by mild hydrogenation of a pre-adsorbed organometallic precursor, and characterized by TEM, XRD, XPS, and hydrogen chemisorption measurements. The catalyst contains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63bf37fcc0d3f6999f40fece281367d1
https://doi.org/10.1016/j.apcata.2014.03.009

Ruthenium-Clotrimazole complex has significant efficacy in the murine model of cutaneous leishmaniasis

Autor: Eva Iniguez, Roberto A. Sánchez-Delgado, Armando Varela-Ramirez, Rosa A. Maldonado, Caresse L. Torres, Alberto Martínez

In previous studies we reported a novel series of organometallic compounds, RuII complexed with clotrimazole, displaying potent trypanosomatid activity with unnoticeable toxicity toward normal mammalian cells. In view of the promising activity of Ru-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1632dc9bc3ed091ae5be923210fc0007
https://europepmc.org/articles/PMC5108180/

The antimalarial activity of Ru–chloroquine complexes against resistant Plasmodium falciparum is related to lipophilicity, basicity, and heme aggregation inhibition ability near water/n-octanol interfaces

Autor: C. S. K. Rajapakse, Roberto A. Sánchez-Delgado, Dalanda Jalloh, Cula Dautriche, Alberto Martínez

Publikováno v: JBIC Journal of Biological Inorganic Chemistry. 14:863-871

We have measured water/n-octanol partition coefficients, pK(a) values, heme binding constants, and heme aggregation inhibition activity of a series of ruthenium-pi-arene-chloroquine (CQ) complexes recently reported to be active against CQ-resistant s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0993260e2d8a05220f52c6a664840e
https://doi.org/10.1007/s00775-009-0498-4