Výsledky vyhledávání - "Roberto A, Perego"

Akademický článek

High glucose induces an activated state of partial epithelial-mesenchymal transition in human primary tubular cell cultures.

Autor: Barbara Torsello, Sofia De Marco, Silvia Bombelli, Ingrid Cifola, Ivana Morabito, Lara Invernizzi, Chiara Meregalli, Nicola Zucchini, Guido Strada, Roberto A Perego, Cristina Bianchi

Publikováno v: PLoS ONE, Vol 18, Iss 2, p e0279655 (2023)

Tubulointerstitial fibrosis is observed in diabetic nephropathy. It is still debated whether tubular cells, undergoing epithelial-mesenchymal transition (EMT) in high glucose (HG) conditions, may contribute to interstitial fibrosis development. In th

Externí odkaz: https://doaj.org/article/fcfc5cc4d8ff4c9ead6935e63ffb9e95

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Akademický článek

Integrated Genomic, Functional, and Prognostic Characterization of Atypical Chronic Myeloid Leukemia

Publikováno v: HemaSphere, Vol 4, Iss 6, p e497 (2020)

Abstract. Atypical chronic myeloid leukemia (aCML) is a BCR-ABL1-negative clonal disorder, which belongs to the myelodysplastic/myeloproliferative group. This disease is characterized by recurrent somatic mutations in SETBP1, ASXL1 and ETNK1 genes, a

Externí odkaz: https://doaj.org/article/3319347f08c04865829698754ec8c474

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Akademický článek

The 1ALCTL and 1BLCTL isoforms of Arg/Abl2 induce fibroblast activation and extra cellular matrix remodelling differently

Autor: Barbara Torsello, Sofia De Marco, Silvia Bombelli, Elisa Chisci, Valeria Cassina, Roberta Corti, Davide Bernasconi, Roberto Giovannoni, Cristina Bianchi, Roberto A. Perego

Publikováno v: Biology Open, Vol 8, Iss 3 (2019)

The fibrotic tissue and the stroma adjacent to cancer cells are characterised by the presence of activated fibroblasts (myofibroblasts) which play a role in creating a supportive tissue characterised by abundant extracellular matrix (ECM) secretion.

Externí odkaz: https://doaj.org/article/3e807f970e4a4bee82742fb97e4cffb2

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The cross-talk between Abl2 tyrosine kinase and TGFβ1 signalling modulates the invasion of clear cell Renal Cell Carcinoma cells

Autor: Sofia De Marco, Barbara Torsello, Emanuela Minutiello, Ivana Morabito, Chiara Grasselli, Silvia Bombelli, Nicola Zucchini, Giuseppe Lucarelli, Guido Strada, Roberto A. Perego, Cristina Bianchi

Clear cell Renal Cell Carcinoma (ccRCC) is the most common and metastatic urological cancer. Molecular players of ccRCC progression and metastasis are not completely known. Here, using primary cell cultures from patients' specimens, we found that TGF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774eaa57953149cd31cb5e98f1e21ea1
https://hdl.handle.net/10281/397215

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Akademický článek

Integration of Lipidomics and Transcriptomics Reveals Reprogramming of the Lipid Metabolism and Composition in Clear Cell Renal Cell Carcinoma

Autor: Giuseppe Lucarelli, Matteo Ferro, Davide Loizzo, Cristina Bianchi, Daniela Terracciano, Francesco Cantiello, Lauren N. Bell, Stefano Battaglia, Camillo Porta, Angela Gernone, Roberto A. Perego, Eugenio Maiorano, Ottavio de Cobelli, Giuseppe Castellano, Leonardo Vincenti, Pasquale Ditonno, Michele Battaglia

Publikováno v: Metabolites, Vol 10, Iss 12, p 509 (2020)

Clear cell renal cell carcinoma (ccRCC) is fundamentally a metabolic disease. Given the importance of lipids in many cellular processes, in this study we delineated a lipidomic profile of human ccRCC and integrated it with transcriptomic data to conn

Externí odkaz: https://doaj.org/article/49138e0d859d4ca684542efd3e563f75

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Akademický článek

PKHhigh/CD133+/CD24− Renal Stem-Like Cells Isolated from Human Nephrospheres Exhibit In Vitro Multipotency

Autor: Silvia Bombelli, Chiara Meregalli, Chiara Grasselli, Maddalena M. Bolognesi, Antonino Bruno, Stefano Eriani, Barbara Torsello, Sofia De Marco, Davide P. Bernasconi, Nicola Zucchini, Paolo Mazzola, Cristina Bianchi, Marco Grasso, Adriana Albini, Giorgio Cattoretti, Roberto A. Perego

Publikováno v: Cells, Vol 9, Iss 8, p 1805 (2020)

The mechanism upon which human kidneys undergo regeneration is debated, though different lineage-tracing mouse models have tried to explain the cellular types and the mechanisms involved. Different sources of human renal progenitors have been propose

Externí odkaz: https://doaj.org/article/3456993bd2a044e8905f078dc4140cd6

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DNA Damage in Circulating Hematopoietic Progenitor Stem Cells as Promising Biological Sensor of Frailty

Autor: Chiara Grasselli, Silvia Bombelli, Stefano Eriani, Giulia Domenici, Riccardo Galluccio, Chiara Tropeano, Sofia De Marco, Maddalena M Bolognesi, Barbara Torsello, Cristina Bianchi, Laura Antolini, Fabio Rossi, Paolo Mazzola, Valerio Leoni, Giuseppe Bellelli, Roberto A Perego

Publikováno v: The journals of gerontology. Series A, Biological sciences and medical sciences. 77(7)

Frailty is an age-related syndrome that exposes individuals to increased vulnerability. Although it is potentially reversible, in most cases it leads to negative outcomes, including mortality. The different methods proposed identify frailty after the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6410b0fea72abc3c31533aaba8f601b2
https://pubmed.ncbi.nlm.nih.gov/35137086

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