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Autor:
Maria Chiara Barsotti, Nadia Ucciferri, Tatiana Santoni, Silvia Rocchiccioli, Anna Maria Piras, Rossella Di Stefano, Angela Pucci, Francesca Felice, Antonella Cecchettini, Silvia Burchielli, Roberto Solaro, Angelina Altomare, Federica Chiellini
Publikováno v:
International Journal of Pharmaceutics. 542:82-89
Endothelial progenitor cells (EPCs) contribute to ischemic tissue repair by paracrine secretion up-regulated by hypoxia. In this study we use novel nanoparticles (NPs) as carriers for a controlled release of EPC secretome (CM) to improve their angiog
Autor:
R. Di Stefano, A. Magera, Antonio Minnocci, Dinuccio Dinucci, C Armani, Federica Chiellini, Anna Maria Piras, Alberto Balbarini, Roberto Solaro, Maria Chiara Barsotti, Giorgio Soldani, Francesca Felice
Publikováno v:
Cell Proliferation. 44:33-48
Objectives: Transplantation of endothelial progenitor cells (EPCs) is a promising approach for revascularization of tissue. We have used a natural and biocompatible biopolymer, fibrin, to induce cell population growth, differentiation and functional
Publikováno v:
Materials, Vol 3, Iss 3, Pp 1928-1980 (2010)
Materials
Materials
Recent advances in biotechnology demonstrate that peptides and proteins are the basis of a new generation of drugs. However, the transportation of protein drugs in the body is limited by their high molecular weight, which prevents the crossing of tis
Publikováno v:
Journal of Polymer Science Part A: Polymer Chemistry. 48:986-990
INTRODUCTION Various hydrogel materials have been developed for use as delivery vehicles of bioactive molecules and cells in tissue engineering. In this respect, injectable hydrogel materials, which can gel under physiological conditions, hold great
Autor:
Roberto Solaro, Celia Duce, Federica Chiellini, Andrea Desii, Lisa Ghezzi, Susanna Monti, Maria Rosaria Tine
Publikováno v:
Journal of Polymer Science Part A: Polymer Chemistry. 48:889-897
We investigated the self-aggregation of 12 short ionic oligopeptides constituted by 4-7 amino acid residues to establish useful structure-property relationships that might be exploited in the biomedical field by using the concept of molecular Lego. W
Publikováno v:
Macromolecules. 42:7388-7395
Multiblock copolymers containing periodically spaced side-chain carboxyl groups were obtained by a two-step synthesis involving the preparation of ABA triblock prepolymers of lactic acid (A block) and ethylene glycol (B block) followed by chain exten
Publikováno v:
Journal of Thermal Analysis and Calorimetry. 97:791-796
The self-aggregation of two short ionic tetrapeptides (RWDW and RVDV, where R = arginine, V = valine, W = tryptophan, D = aspartic acid) was studied by different experimental techniques such as, atomic force microscopy (AFM), light scattering (LS), i
Autor:
Alessio Micheli, Maria Rosaria Tine, Celia Duce, Antonina Starita, Roberto Solaro, C. Bertinetto
Publikováno v:
Journal of Molecular Graphics and Modelling. 27:797-802
This paper reports some recent results from the empirical evaluation of different types of structured molecular representations used in QSPR analysis through a recursive neural network (RNN) model, which allows for their direct use without the need f
Publikováno v:
Journal of Polymer Science Part A: Polymer Chemistry. 46:2459-2476
This work aimed at the development of bioactive polymeric materials to be used for targeted drug delivery and tissue engineering applications. The proposed strategy was based on the design of macromolecular systems whose functionality can be easily m