Structural Basis of Human Dimeric α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Inhibition With TES-1025

Autor: Michele Cianci, Nicola Giacchè, Lucia Cialabrini, Andrea Carotti, Paride Liscio, Emiliano Rosatelli, Francesca De Franco, Massimiliano Gasparrini, Janet Robertson, Adolfo Amici, Nadia Raffaelli, Roberto Pellicciari

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) stands at a branch point of the de novo NAD+ synthesis pathway and plays an important role in maintaining NAD+ homeostasis. It has been recently identified as a novel therapeutic

Externí odkaz: https://doaj.org/article/939b4944020c4a4f9cf2c164cbbc4724

Supplementary Figures S1-9, Tables S1 and 2 from Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy

Autor: Fabiola Moretti, Antonio Macchiarulo, Jean Christophe Marine, Alfredo Pontecorvi, Roberto Pellicciari, Giulia Piaggio, Mara D'Onofrio, Maurizio Fanciulli, Tiziana Bruno, Rossella Brandi, Laura Fici, Marianna Buttarelli, Emanuela Teveroni, Fulvio Florenzano, Ivan Arisi, Isabella Manni, Nicola Giacchè, Alice Coletti, Rossella Lucà, Francesca Mancini, Marsha Pellegrino

Supplementary Figures S1-9, Tables S1 and 2. Supplementary Figure S1: Analysis of p53 ubiquitination and binding Supplementary Figure S2: Pep3 activity in human tumor cell lines Supplementary Figure S3: Pep3 activity in untransformed cells Supplement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f412cf386837aee8ea282366fd89e0
https://doi.org/10.1158/0008-5472.22405989.v1

First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53

Autor: Eline Hendrix, Anthony Tumber, Klemensas Simelis, Mathew L. Coleman, Nicola Mautone, Akane Kawamura, Catrine Johansson, Alessia Ciogli, Udo Oppermann, Dante Rotili, Lorenzo Antonini, Manuela Sabatino, Daniela Passeri, Antonello Mai, Mohammad Salik Zeya Ansari, Regina Andrijes, Daniela Trisciuoglio, Eidarus Salah, Donatella Del Bufalo, Francesca Romana Pellegrini, Radosław P Nowak, Roberto Pellicciari, Rino Ragno, Christopher J. Schofield

Publikováno v: Journal of Medicinal Chemistry
Journal of medicinal chemistry 64 (2021): 17031–17050. doi:10.1021/acs.jmedchem.1c00605
info:cnr-pdr/source/autori:Nowak R.P.; Tumber A.; Hendrix E.; Ansari M.S.Z.; Sabatino M.; Antonini L.; Andrijes R.; Salah E.; Mautone N.; Pellegrini F.R.; Simelis K.; Kawamura A.; Johansson C.; Passeri D.; Pellicciari R.; Ciogli A.; Del Bufalo D.; Ragno R.; Coleman M.L.; Trisciuoglio D.; Mai A.; Oppermann U.; Schofield C.J.; Rotili D./titolo:First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53/doi:10.1021%2Facs.jmedchem.1c00605/rivista:Journal of medicinal chemistry/anno:2021/pagina_da:17031/pagina_a:17050/intervallo_pagine:17031–17050/volume:64

MINA53 is a JmjC domain 2-oxoglutarate-dependent oxygenase that catalyzes ribosomal hydroxylation and is a target of the oncogenic transcription factor c-MYC. Despite its anticancer target potential, no small-molecule MINA53 inhibitors are reported.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7a2018a4fda17782bb28cfc487a6ff
https://doi.org/10.1021/acs.jmedchem.1c00605

Synthesis and Quantitative Structure-Property Relationships of Side Chain-Modified Hyodeoxycholic Acid Derivatives

Autor: Antimo Gioiello, Antonio Macchiarulo, Roberto Pellicciari, Roberto Nuti, Roccaldo Sardella, Benedetto Natalini, Paola Sabbatini, Paolo Filipponi

Publikováno v: Molecules, Vol 18, Iss 9, Pp 10497-10513 (2013)

Bile acids have emerged as versatile signalling compounds of a complex network of nuclear and membrane receptors regulating various endocrine and paracrine functions. The elucidation of the interconnection between the biological pathways under the bi

Externí odkaz: https://doaj.org/article/8e4133ca8e6640ba9b50e69e84beee9c

Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication

Autor: Marco Gargaro, Giulia Scalisi, Giorgia Manni, Carlos G. Briseño, Prachi Bagadia, Vivek Durai, Derek J. Theisen, Sunkyung Kim, Marilena Castelli, Chenling A. Xu, Gerd Meyer zu Hörste, Giuseppe Servillo, Maria A. Della Fazia, Giulia Mencarelli, Doriana Ricciuti, Eleonora Padiglioni, Nicola Giacchè, Carolina Colliva, Roberto Pellicciari, Mario Calvitti, Teresa Zelante, Dietmar Fuchs, Ciriana Orabona, Louis Boon, Alban Bessede, Marco Colonna, Paolo Puccetti, Theresa L. Murphy, Kenneth M. Murphy, Francesca Fallarino

Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is used by cDCs in maintaining tolerance, but its role in different su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fb6c294a099bfdb930d914d491d3a6
https://hdl.handle.net/11391/1535413