Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Roberto, Gianani"'
Autor:
Will Paces, Elliott Ergon, Elizabeth Bueche, G. Dave Young, Vitria Adisetiyo, Cris Luengo, Meredith James, Charles Caldwell, Dannah Miller, Morgan Wambaugh, Geoffrey Metcalf, Roberto Gianani
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract PD-L1 (22C3) checkpoint inhibitor therapy represents a mainstay of modern cancer immunotherapy for non-small cell lung cancer (NSCLC). In vitro diagnostic (IVD) PD-L1 antibody staining is widely used to predict clinical intervention efficacy
Externí odkaz:
https://doaj.org/article/fcfbd68415114c36b101185dfdc94015
Autor:
Charles Caldwell, James B. Rottman, Will Paces, Elizabeth Bueche, Sofia Reitsma, Joseph Gibb, Vitria Adisetiyo, Michael S. Haas, Heidi Heath, Walter Newman, Jason Baum, Roberto Gianani, Michael H. Kagey
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Dickkopf-1 (DKK1) is a secreted modulator of Wnt signaling that is frequently overexpressed in tumors and associated with poor clinical outcomes. DKN-01 is a humanized monoclonal therapeutic antibody that binds DKK1 with high affinity and ha
Externí odkaz:
https://doaj.org/article/386bfb9934384f32ac9a8bd2228acb37
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/6ef63ade744842aca26518f2e1ee9819
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundImmune cells within the tumor microenvironment (TME) play a vital role in regulating tumor progression. Therefore, immunotherapies that stimulate anti-tumor responses are of great interest for the treatment of various cancers. PD-L1 express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324f1b8e2d6c5a5f3937109da16673af
https://doaj.org/article/6ef63ade744842aca26518f2e1ee9819
https://doaj.org/article/6ef63ade744842aca26518f2e1ee9819
Autor:
Liping Yu, Michael P. Morran, Dorothy J. Becker, Howard W. Davidson, Shuai Huang, Andrew D Vonberg, Massimo Pietropaolo, Charles F. Verge, Roberto Gianani, Maria Acevedo-Calado, Susan L. Pietropaolo, Stephen S. Rich, Carla J. Greenbaum, Santiago Schnell, Aaron W. Michels
Publikováno v:
Diabetes
We identified autoantibodies (AAb) reacting with a variant IA-2 molecule (IA-2var) that has three amino acid substitutions (Cys27, Gly608, and Pro671) within the full-length molecule. We examined IA-2var AAb in first-degree relatives of type 1 diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5131e2d5c29a6f394031271fbb16c72b
https://doi.org/10.2337/db18-1351
https://doi.org/10.2337/db18-1351
Publikováno v:
Cancer Research. 82:2530-2530
Background: Immune cells within the tumor microenvironment (TME) play a vital role in regulating tumor progression. Therefore, immunotherapies that elicit anti-tumor responses are of great interest for the treatment of various cancers. Macrophages ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9a4bdb0d87e5de108726ef783b71369
https://doi.org/10.1158/1538-7445.am2022-2530
https://doi.org/10.1158/1538-7445.am2022-2530
Publikováno v:
Cancer Research. 82:1720-1720
Background: Immune cells within the tumor microenvironment (TME) play a vital role in regulating tumor progression. Therefore, immunotherapies that elicit anti-tumor responses are of great interest for the treatment of various cancers. Macrophages ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::921bf71bbcbb329160c11c6d36102706
https://doi.org/10.1158/1538-7445.am2022-1720
https://doi.org/10.1158/1538-7445.am2022-1720
Autor:
Angela Subauste, Roberto Gianani, Annette M Chang, Cynthia Plunkett, Susan L Pietropaolo, Ying-Jian Zhang, Emma Barinas-Mitchell, Lewis H Kuller, Andrzej Galecki, Jeffrey B Halter, Massimo Pietropaolo
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106537 (2014)
There is a paucity of literature describing metabolic and histological data in adult-onset autoimmune diabetes. This subgroup of diabetes mellitus affects at least 5% of clinically diagnosed type 2 diabetic patients (T2DM) and it is termed Latent Aut
Externí odkaz:
https://doaj.org/article/acf064debaab47c4acfb1cf4f1bdcab2
Autor:
Jason Baum, Will Paces, Walter Newman, Vitria Adisetiyo, Elizabeth Bueche, Sofia Reitsma, Roberto Gianani, James B. Rottman, Michael Haas, Joseph Gibb, Michael H. Kagey, Heidi Heath, Charles C. Caldwell
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Dickkopf-1 (DKK1) is a secreted modulator of Wnt signaling that is frequently overexpressed in tumors and associated with poor clinical outcomes. DKN-01 is a humanized monoclonal therapeutic antibody that binds DKK1 with high affinity and has demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7d862b7710a8195dbbe395878b9a4b
https://doi.org/10.1038/s41598-021-89060-3
https://doi.org/10.1038/s41598-021-89060-3
Autor:
Elliott Ergon, Kristin Shotts, Will Paces, Charles W. Caldwell, Roberto Gianani, Vitria Adisetiyo
Publikováno v:
Regular and young investigator award abstracts.
Background Determination of programmed death-ligand 1 (PD-L1) level in tumor by immunohistochemistry (IHC) is widely used to predict response to check point inhibitor therapy. In particular, the Dako PD-L1 (22C3) antibody is a common companion diagno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56ea754a928bca91a0c10619cc3b6dd1
https://doi.org/10.1136/jitc-2020-sitc2020.0038
https://doi.org/10.1136/jitc-2020-sitc2020.0038