Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Roberto, Gianani"'
Autor:
Will Paces, Elliott Ergon, Elizabeth Bueche, G. Dave Young, Vitria Adisetiyo, Cris Luengo, Meredith James, Charles Caldwell, Dannah Miller, Morgan Wambaugh, Geoffrey Metcalf, Roberto Gianani
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract PD-L1 (22C3) checkpoint inhibitor therapy represents a mainstay of modern cancer immunotherapy for non-small cell lung cancer (NSCLC). In vitro diagnostic (IVD) PD-L1 antibody staining is widely used to predict clinical intervention efficacy
Externí odkaz:
https://doaj.org/article/fcfbd68415114c36b101185dfdc94015
Autor:
Charles Caldwell, James B. Rottman, Will Paces, Elizabeth Bueche, Sofia Reitsma, Joseph Gibb, Vitria Adisetiyo, Michael S. Haas, Heidi Heath, Walter Newman, Jason Baum, Roberto Gianani, Michael H. Kagey
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Dickkopf-1 (DKK1) is a secreted modulator of Wnt signaling that is frequently overexpressed in tumors and associated with poor clinical outcomes. DKN-01 is a humanized monoclonal therapeutic antibody that binds DKK1 with high affinity and ha
Externí odkaz:
https://doaj.org/article/386bfb9934384f32ac9a8bd2228acb37
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/6ef63ade744842aca26518f2e1ee9819
Publikováno v:
Cancer Research. 82:2530-2530
Background: Immune cells within the tumor microenvironment (TME) play a vital role in regulating tumor progression. Therefore, immunotherapies that elicit anti-tumor responses are of great interest for the treatment of various cancers. Macrophages ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9a4bdb0d87e5de108726ef783b71369
https://doi.org/10.1158/1538-7445.am2022-2530
https://doi.org/10.1158/1538-7445.am2022-2530
Publikováno v:
Cancer Research. 82:1720-1720
Background: Immune cells within the tumor microenvironment (TME) play a vital role in regulating tumor progression. Therefore, immunotherapies that elicit anti-tumor responses are of great interest for the treatment of various cancers. Macrophages ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::921bf71bbcbb329160c11c6d36102706
https://doi.org/10.1158/1538-7445.am2022-1720
https://doi.org/10.1158/1538-7445.am2022-1720
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundImmune cells within the tumor microenvironment (TME) play a vital role in regulating tumor progression. Therefore, immunotherapies that stimulate anti-tumor responses are of great interest for the treatment of various cancers. PD-L1 express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324f1b8e2d6c5a5f3937109da16673af
https://doaj.org/article/6ef63ade744842aca26518f2e1ee9819
https://doaj.org/article/6ef63ade744842aca26518f2e1ee9819
Autor:
Peter Keller, Irina Mazo, Yun Gao, Vijayapal Reddy, Francisco Caballero, Sam Kazer, Dannah Miller, Roberto Gianani, James E. Marvin, Bret Stephens, Gregory L. Beatty, Ulrich H. von Andrian, Thorsten R. Mempel
Publikováno v:
Molecular Cancer Therapeutics. 20:P106-P106
Background Despite transforming effects of immune checkpoint blockade (ICB) therapy, objective response rates are low for most solid tumors. In the tumor microenvironment (TME), regulatory T cells are functionally unstable, likely due to changes in T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e698dde840a990ee32bf7546a156ed50
https://doi.org/10.1158/1535-7163.targ-21-p106
https://doi.org/10.1158/1535-7163.targ-21-p106
Autor:
Liping Yu, Michael P. Morran, Dorothy J. Becker, Howard W. Davidson, Shuai Huang, Andrew D Vonberg, Massimo Pietropaolo, Charles F. Verge, Roberto Gianani, Maria Acevedo-Calado, Susan L. Pietropaolo, Stephen S. Rich, Carla J. Greenbaum, Santiago Schnell, Aaron W. Michels
Publikováno v:
Diabetes
We identified autoantibodies (AAb) reacting with a variant IA-2 molecule (IA-2var) that has three amino acid substitutions (Cys27, Gly608, and Pro671) within the full-length molecule. We examined IA-2var AAb in first-degree relatives of type 1 diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5131e2d5c29a6f394031271fbb16c72b
https://doi.org/10.2337/db18-1351
https://doi.org/10.2337/db18-1351
Autor:
Angela Subauste, Roberto Gianani, Annette M Chang, Cynthia Plunkett, Susan L Pietropaolo, Ying-Jian Zhang, Emma Barinas-Mitchell, Lewis H Kuller, Andrzej Galecki, Jeffrey B Halter, Massimo Pietropaolo
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106537 (2014)
There is a paucity of literature describing metabolic and histological data in adult-onset autoimmune diabetes. This subgroup of diabetes mellitus affects at least 5% of clinically diagnosed type 2 diabetic patients (T2DM) and it is termed Latent Aut
Externí odkaz:
https://doaj.org/article/acf064debaab47c4acfb1cf4f1bdcab2
Autor:
Jason Baum, Will Paces, Walter Newman, Vitria Adisetiyo, Elizabeth Bueche, Sofia Reitsma, Roberto Gianani, James B. Rottman, Michael Haas, Joseph Gibb, Michael H. Kagey, Heidi Heath, Charles C. Caldwell
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Dickkopf-1 (DKK1) is a secreted modulator of Wnt signaling that is frequently overexpressed in tumors and associated with poor clinical outcomes. DKN-01 is a humanized monoclonal therapeutic antibody that binds DKK1 with high affinity and has demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7d862b7710a8195dbbe395878b9a4b
https://doi.org/10.1038/s41598-021-89060-3
https://doi.org/10.1038/s41598-021-89060-3