Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Roberto, De Pascalis"'
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT We examined the relationship between the association of a vaccine antigen with immune cells in secondary lymphoid organs shortly after immunization and the resulting neutralizing antibody response induced by that antigen using three antigeni
Externí odkaz:
https://doaj.org/article/25465a5e59ab47d09da9ab221a0bcb0a
Autor:
Roberto De Pascalis, Blake Frey, Helen M. Rice, Varunika Bhargava, Terry H. Wu, Ross L. Peterson, J. Wayne Conlan, Anders Sjöstedt, Karen L. Elkins
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-14 (2022)
Abstract Francisella tularensis, the causative agent of tularemia, is classified as Tier 1 Select Agent with bioterrorism potential. The efficacy of the only available vaccine, LVS, is uncertain and it is not licensed in the U.S. Previously, by using
Externí odkaz:
https://doaj.org/article/45867fd5b2b64f7ea1f1656039948dd5
Autor:
Roberto De Pascalis, Varunika Bhargava, Scott Espich, Terry H. Wu, H. Carl Gelhaus, Karen L. Elkins
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Identifying suitable animal models and standardizing preclinical methods are important for the generation, characterization, and development of new vaccines, including those against Francisella tularensis. Non-human primates represent an important an
Externí odkaz:
https://doaj.org/article/4726494384c1437eadcf0523c2e454f5
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0283161 (2023)
IL-12p40 plays an important role in F. tularensis Live Vaccine Strain (LVS) clearance that is independent of its functions as a part of the heterodimeric cytokines IL-12p70 or IL-23. In contrast to WT, p35, or p19 knockout (KO) mice, p40 KO mice infe
Externí odkaz:
https://doaj.org/article/795a9836485b4038a4c423df36e203da
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0249142 (2021)
CCR2 is the major chemokine receptor that regulates appropriate trafficking of inflammatory monocytes, but the role of this chemokine receptor and its ligands during primary and secondary infection with intracellular infections remains incompletely u
Externí odkaz:
https://doaj.org/article/40c254739e9d45658cb6084bc8db9235
Autor:
Roberto De Pascalis, Amy P Rossi, Lara Mittereder, Kazuyo Takeda, Adovi Akue, Sherry L Kurtz, Karen L Elkins
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237034 (2020)
Production of IFN-γ is a key innate immune mechanism that limits replication of intracellular bacteria such as Francisella tularensis (Ft) until adaptive immune responses develop. Previously, we demonstrated that the host cell types responsible for
Externí odkaz:
https://doaj.org/article/a2ed8fdb6e5040ad9e4817799e1499a2
Autor:
J. Wayne Conlan, Anders Sjöstedt, H. Carl Gelhaus, Perry Fleming, Kevan McRae, Ronald R. Cobb, Roberto De Pascalis, Karen L. Elkins
Publikováno v:
Pathogens, Vol 10, Iss 7, p 795 (2021)
Inhalation of small numbers of Francisella tularensis subspecies tularensis (Ftt) in the form of small particle aerosols causes severe morbidity and mortality in people and many animal species. For this reason, Ftt was developed into a bona fide biol
Externí odkaz:
https://doaj.org/article/fc3bce072b1c44ab94a56b3f63811d93
Autor:
Roberto De Pascalis, Andrew Hahn, Helen M Brook, Patrik Ryden, Nathaniel Donart, Lara Mittereder, Blake Frey, Terry H Wu, Karen L Elkins
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0198140 (2018)
There are no defined correlates of protection for any intracellular pathogen, including the bacterium Francisella tularensis, which causes tularemia. Evaluating vaccine efficacy against sporadic diseases like tularemia using field trials is problemat
Externí odkaz:
https://doaj.org/article/ca1e6c3957f348d9b85a34749eae8b6e
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126570 (2015)
In the last decade several new vaccines against Francisella tularensis, which causes tularemia, have been characterized in animal models. Whereas many of these vaccine candidates showed promise, it remains critical to bridge the preclinical studies t
Externí odkaz:
https://doaj.org/article/c83be5255fb7464b8809c78a7cfa3357
Autor:
Roberto De Pascalis, Kevan Mcrae, H Carl Gelhaus, Ronald R Cobb, Perry Fleming, Anders Sjöstedt, J. Wayne Conlan, Karen L. Elkins
Publikováno v:
Pathogens
Volume 10
Issue 7
Pathogens, Vol 10, Iss 795, p 795 (2021)
Volume 10
Issue 7
Pathogens, Vol 10, Iss 795, p 795 (2021)
Inhalation of small numbers of Francisella tularensis subspecies tularensis (Ftt) in the form of small particle aerosols causes severe morbidity and mortality in people and many animal species. For this reason, Ftt was developed into a bona fide biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c830de1fe622f83788595eed06278c
https://nrc-publications.canada.ca/eng/view/object/?id=366ee55b-0949-4f5b-b2aa-c18cab1878e5
https://nrc-publications.canada.ca/eng/view/object/?id=366ee55b-0949-4f5b-b2aa-c18cab1878e5