Quantum Molecular Resonance Inhibits NLRP3 Inflammasome/Nitrosative Stress and Promotes M1 to M2 Macrophage Polarization: Potential Therapeutic Effect in Osteoarthritis Model In Vitro

Autor: Teresa Paolucci, Vanessa Pino, Osama Elsallabi, Marialucia Gallorini, Gianantonio Pozzato, Alessandro Pozzato, Paola Lanuti, Victor Machado Reis, Mirko Pesce, Andrea Pantalone, Roberto Buda, Antonia Patruno

Publikováno v: Antioxidants, Vol 12, Iss 7, p 1358 (2023)

This study aimed to investigate the anti-inflammatory effects of Quantum Molecular Resonance (QMR) technology in an in vitro model of osteoarthritis-related inflammation. The study used THP-1-derived macrophages stimulated with lipopolysaccharide and

Externí odkaz: https://doaj.org/article/ba052f36cf4e461fab739228a9c27c67

Effective Label-Free Sorting of Multipotent Mesenchymal Stem Cells from Clinical Bone Marrow Samples

Autor: Silvia Zia, Carola Cavallo, Ilaria Vigliotta, Valentina Parisi, Brunella Grigolo, Roberto Buda, Pasquale Marrazzo, Francesco Alviano, Laura Bonsi, Andrea Zattoni, Pierluigi Reschiglian, Barbara Roda

Publikováno v: Bioengineering, Vol 9, Iss 2, p 49 (2022)

Mesenchymal stem cells (MSC) make up less than 1% of the bone marrow (BM). Several methods are used for their isolation such as gradient separation or centrifugation, but these methodologies are not direct and, thus, plastic adherence outgrowth or ma

Externí odkaz: https://doaj.org/article/f83680c90c3e47e5b639fc469e7cd9ed

Three-Dimensional Co-Culture System of Human Osteoblasts and Osteoclast Precursors from Osteoporotic Patients as an Innovative Model to Study the Role of Nutrients: Focus on Vitamin K2

Autor: Domitilla Mandatori, Letizia Penolazzi, Letizia Pelusi, Elisabetta Lambertini, Francesca Michelucci, Annamaria Porreca, Pietro Cerritelli, Caterina Pipino, Angelo Di Iorio, Danilo Bruni, Marta Di Nicola, Roberto Buda, Roberta Piva, Assunta Pandolfi

Publikováno v: Nutrients, Vol 13, Iss 8, p 2823 (2021)

Several natural compounds, such as vitamin K2, have been highlighted for their positive effects on bone metabolism. It has been proposed that skeletal disorders, such as osteoporosis, may benefit from vitamin K2-based therapies or its regular intake.

Externí odkaz: https://doaj.org/article/43c7b31bfb9942168aa971926e22f1a6

Terminology for osteochondral lesions of the ankle: proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle

Autor: Christopher D. Murawski, M. Shazil Jamal, Eoghan T. Hurley, Roberto Buda, Kenneth Hunt, Graham McCollum, Jochen Paul, Francesca Vannini, Markus Walther, Youichi Yasui, Zakariya Ali, J Nienke Altink, Jorge Batista, Steve Bayer, Gregory C. Berlet, James D.F. Calder, Jari Dahmen, Martin S. Davey, Pieter D’Hooghe, Christopher W. DiGiovanni, Richard D. Ferkel, Arianna L. Gianakos, Eric Giza, Mark Glazebrook, Laszlo Hangody, Daniel Haverkamp, Beat Hintermann, Yinghui Hua, Daire J. Hurley, Jón Karlsson, Stephen Kearns, John G. Kennedy, Gino M.M.J. Kerkhoffs, Kaj Lambers, Jin Woo Lee, Nathaniel P. Mercer, Conor Mulvin, James A. Nunley, Christopher Pearce, Helder Pereira, Marcelo Prado, Steven M. Raikin, Ian Savage-Elliott, Lew C. Schon, Yoshiharu Shimozono, James W. Stone, Sjoerd A.S. Stufkens, Martin Sullivan, Masato Takao, Hajo Thermann, David Thordarson, James Toale, Victor Valderrabano, Christiaan J.A. van Bergen, C. Niek van Dijk, Raymond J. Walls, Alastair S. Younger, MaCalus V. Hogan

Publikováno v: Journal of ISAKOS, 7(2), 62-66. BMJ Publishing Group
Murawski, C D, Jamal, M S, Hurley, E T, Buda, R, Hunt, K, McCollum, G, Paul, J, Vannini, F, Walther, M, Yasui, Y, Ali, Z, Altink, J N, Batista, J, Bayer, S, Berlet, G C, Calder, J D F, Dahmen, J, Davey, M S, D'Hooghe, P, DiGiovanni, C W, Ferkel, R D, Gianakos, A L, Giza, E, Glazebrook, M, Hangody, L, Haverkamp, D, Hintermann, B, Hua, Y, Hurley, D J, Karlsson, J N, Kearns, S, Kennedy, J G, Kerkhoffs, G M M J, Lambers, K, Lee, J W, Mercer, N P, Mulvin, C, Nunley, J A, Pearce, C, Pereira, H, Prado, M, Raikin, S M, Savage-Elliott, I, Schon, L C, Shimozono, Y, Stone, J W, Stufkens, S A S, Sullivan, M, Takao, M, Thermann, H, Thordarson, D, Toale, J, Valderrabano, V, van Bergen, C J A, van Dijk, C N, Walls, R J, Younger, A S & Hogan, M V 2022, ' Terminology for osteochondral lesions of the ankle : proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle ', Journal of ISAKOS, vol. 7, no. 2, pp. 62-66 . https://doi.org/10.1016/j.jisako.2021.12.001

Background: The evidence supporting best practice guidelines in the field of cartilage repair of the ankle is based on both low quality and low levels of evidence. Therefore, an international consensus group of experts was convened to collaboratively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3de4e7fafd949d630ccbe4c5bef295
https://doi.org/10.1016/j.jisako.2021.12.001

Bone marrow aspirate concentrate and scaffold for osteochondral lesions of the talus in ankle osteoarthritis: satisfactory clinical outcome at 10 years

Autor: Francesca Vannini, Sandro Giannini, Laura Ramponi, Sante Alessandro Altamura, Cesare Faldini, Emanuele Di Quattro, Roberto Buda, Giuseppe Filardo

Publikováno v: Knee Surgery, Sports Traumatology, Arthroscopy. 29:2504-2510

PURPOSE: To evaluate at long-term follow-up patients undergoing a one-step procedure of debridement and BMAC seeded in situ onto a scaffold for the treatment of osteochondral lesions of the talus (OLT) in ankles affected by osteoarthritis (OA), docum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6d82aa8985ca519c332c41c972fc0d
https://doi.org/10.1007/s00167-021-06494-y